Articles tagged "Lung transplantation"

2019 American Transplant Congress
Listing Practices and Graft Utilization Lag behind Supply of Hepatitis C Positive Deceased Donors for Liver and Kidney Transplant
C. E. Kling¹, J. D. Perkins², S. W. Biggins³, C. Johnson⁴, A. P. Limaye⁵, L. Sibulesky¹
¹Division of Transplant Surgery, University of Washington Medical Center, Seattle, WA, ²Division of Transplant Surgery and Clinical and Bio-Analytics Transplant Laboratory, University of Washington Medical Center, Seattle, WA, ³Divisions of Gastroenterology and Hepatology and Center for Liver Investigation Fostering DiscovEry, University of Washington Medical Center, Seattle, WA, ⁴Division of Nephrology, University of Washington Medical Center, Seattle, WA, ⁵Division of Infectious Disease, University of Washington Medical Center, Seattle, WA
*Purpose: The opioid epidemic resulted in increasing incidence of hepatitis C (HCV) in the general population and more deceased organ donors with HCV in the…
2018 American Transplant Congress
Characterization of Exosomal DNA from Human Lung Transplant Recipients
S. Bansal, M. Sharma, R. Walia, R. Bremner, M. Smith, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hosp & Med Ctr, Phoenix.
Exosomes are small vesicles which contains biological molecules including proteins, RNA`s and miRNAs. It has been reported that exosomes may contain ds DNA originated from…
2018 American Transplant Congress
Pattern of Respiratory Virus Infection (RVI) and Chronic Lung Allograft Dysfunction (CLAD) in Lung Transplant Recipients (LTR)
L. Somerville, S. Drews, K. Halloran, N. Lee, D. Kabbani, H. Hirji, K. Doucette, C. Cervera.
University of ALberta, Edmonton, AB, Canada.
Background: The indirect effects of RVI in LTR are controversial. We aimed to define patterns of RVI in LTR and the impact on CLAD and…
2018 American Transplant Congress
Simultaneous Persistence and Development of Donor and Recipient Tissue Resident Memory T Cells in Lung Transplantation
M. Snyder,¹ T. Connors,² C. Marboe,³ L. Benvenuto,¹ L. Shah,¹ H. Robbins,¹ J. Hook,¹ F. D'Ovidio,⁴ M. Bacchetta,⁴ J. Sonnett,⁴ S. Arcasoy,¹ D. Farber.^4,5
¹Medicine, Columbia University Medical Center, New York, NY; ²Pediatrics, Columbia University Medical Center, New York, NY; ³Pathology, Columbia University Medical Center, New York, NY; ⁴Surgery, Columbia University Medical Center, New York, NY; ⁵Microbiology & Immunology, Columbia University Medical Center, New York, NY.
Introduction: The predominant T cell population in the lung comprises non-circulating tissue-resident memory T cells (TRM); however, the fate of these cells in transplanted lung…
2018 American Transplant Congress
Superiority of Early Everolimus-Based Quadruple Immunosuppression versus Standard Triple Therapy after Lung Transplantation: 12 Months Results from Prospective 4EVERLUNG Study in Germany
J. Gottlieb, C. Neurohr, J. Müller-Quernheim, H. Wirtz, B. Sill, H. Wilkens, V. Besa, C. Knosalla, M. Junge, C. Capusan, M. Strüber.
Klinik, Hannover, Germany; Klinik, München, Germany; Klinik, Freiburg, Germany; Klinik, Leipzig, Germany; Klinik, Hamburg, Germany; Klinik, Homburg, Germany; Klinik, Essen, Germany; Klinik, Berlin, Germany; Novartis Pharma, Nürnberg, Germany; Novartis Pharma, Nürnberg, Germany; Klinik, Hannover, Germany.
The 4Everlung trial was designed to evaluate the benefit of early everolimus (EVR)-based quadruple low immunosuppressive (IS) regimen on kidney function (RF) after LTx.4EVERLUNG is…
2018 American Transplant Congress
Identification of Exosomal Proteins from Human Lung Transplant Recipients
S. Bansal,¹ P. Pirrotte,² M. Saltzman,² K. Garcia,² M. Sharma,¹ M. Gunasekaran,¹ M. Smith,¹ R. Bremner,¹ T. Mohanakumar.¹
¹Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix; ²Collaborative Center for Translational Mass Spectrophotometry Translational Genomics Research Institute, Phoenix.
Molecular mechanisms involved in rejection following human lung transplantation are not well understood. Goal of this study is to identify proteomic signatures in the circulating…
2018 American Transplant Congress
Ultrastructural Changes in Lung Allografts: Endothelial Changes Correlate with Donor Specific Antibody & Antibody Mediated Rejection
M. Alexander, A. Bentall, P. Abell Aleff, J. Scott, A. Roden.
Mayo Clinic, Rochester, MN.
Introduction: Antibody mediated rejection (AMR) causes lung allograft (LA) injury. Challenges with C4d interpretation & lack of specific histological criteria account for difficulty in diagnosing…
2018 American Transplant Congress
Nontuberculous Mycobacteria in Lung Transplant Recipients: Prevalence, Risk Factors and Impact on Survival and Graft Function
D. Friedman, C. Cervera, K. Halloran, G. Tyrrell, K. Doucette.
University of Alberta, Edmonton, Canada.
BACKGROUND. Nontuberculous mycobacteria (NTM) may colonize or infect lung transplant patients. Due to differences in populations studied and geographical diversity of NTM, risk factors for…
2018 American Transplant Congress
Impact of Changes to the LAS Calculation
R. Lehman,¹ R. Carrico,¹ K. Uccellini,¹ K. Chan,² T. Whelan.³
¹United Network for Organ Sharing, Richmond, VA; ²Univ of Michigan, Ann Arbor, MI; ³Medical Univ of South Carolina, Charleston, SC.
Purpose: On 2/19/2015 major revisions to the Lung Allocation Score (LAS) calculation were made to more appropriately reflect candidates' waiting list urgency and post-transplant survival.…
2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
K. Freischlag,¹ B. Ezekian,¹ P. Schroder,¹ J. Everitt,¹ J. Yoon,¹ M. Swiderska-Syn,³ W. Parker,¹ A. Diehl,¹ J. Kwun,¹ S. Knechtle.¹
¹Duke Transplant Center, Duke University, Durham, NC; ²Medical University of South Carolina, Charleston, SC.
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…