Articles tagged "Lung transplantation"

2019 American Transplant Congress
Effect of Enoxaparin Prophylaxis on Early VTE Post Lung Transplant
S. Marshall¹, K. Tsveybel¹, S. Boukedes¹, P. Burkett², R. Chepuri², A. Coppolino³, M. Divo², S. El-Chemaly², S. Keller², J. Kennedy², H. Mallidi³, G. Mody³, T. Thaniyavarn², A. Trindade², K. Townsend¹, H. Goldberg²
¹Lung Transplant, Brigham & Women's Hospital, Boston, MA, ²Pulmonary Division, Brigham & Women's Hospital, Boston, MA, ³Thoracic Surgery, Brigham & Women's Hospital, Boston, MA
*Purpose: Thromboembolic complications are common post-transplant leading to significant morbidity. We instituted early enoxaparin prophylaxis (ppx) in lung transplant recipients (LTR) due to an observed…
2019 American Transplant Congress
Decline in Club Cell Secretory Protein Results in Immune Responses to Lung Self-Antigens (Kα1 Tubulin and Collagen V) and Development of Chronic Rejection Following Human Lung Transplantation
Y. Itabashi¹, R. Ravichandran¹, M. Sharma¹, R. Hachem², R. Bremner¹, M. Smith¹, T. Mohanakumar¹
¹Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, ²Washington University School of Medicine, St. Louis, MO
*Purpose: Club cell secretory protein (CCSP) levels have been employed as a biomarker for respiratory stress in athletes, asthma patients, and in experimental acute and…
2019 American Transplant Congress
Target Itraconazole Trough Concentration for Prophylaxis in Lung Transplant
J. A. Morillas-Rodriguez¹, H. Hassouna², F. Marco-Canosa³, K. D. Brizendine¹
¹Infectious disease, Cleveland Clinic, Cleveland, OH, ²Infectious disease, Spectrum health, Grand rapids, MI, ³Cleveland Clinic, Cleveland, OH
*Purpose: Itraconazole (ITR) therapeutic drug monitoring (TDM) for prophylaxis in lung transplant recipients (LTR) is not well characterized. Our purpose was to evaluate ITR trough…
2019 American Transplant Congress
Lung Transplantation in the Elderly Patients with Multi-Comorbidities
N. Shigemura, Y. Toyoda
Temple University Health System / Lewis Katz School of Medicine, Philadelphia, PA
*Purpose: Recently there is an outstanding steadily increase in elderly patients above 70 years old who are referred to our center as potential candidates for…
2019 American Transplant Congress
Association between Respiratory Virus Infections and the Development of De Novo HLA Donor-Specific Antibodies in Lung Transplant Recipients
M. I. Ali, J. Hata, J. Mallea, M. Elrefaei
Mayo Clinic, Jacksonville, FL
*Purpose: The detection of de novo donor-specific anti-HLA antibodies (DSA) post lung transplant have been associated with significantly increased risk for antibody-mediated rejection (AMR) and…
2019 American Transplant Congress
Induction Type Does Not Influence Kidney Graft or Patient Survival in Recipients with a Previous Lung Transplant in the United States
S. Riad¹, U. Goswami², S. Jackson³, M. Hertz²
¹Medicine, University of Minnesota, Eden Prairie, MN, ²Medicine, University of Minnesota, Minneapolis, MN, ³Complex Care Analytics, Fairview Health Services, Minneapolis, MN
*Purpose: Induction regimens for kidney transplant alone (KT) in lung recipients vary widely among transplant centers. We sought to examine the impact of kidney induction…
2019 American Transplant Congress
Synergistic Effect of HLA Eplet Mismatch Load and CMV Viremia on Clinical Antibody-Mediated Rejection in Lung Transplantation
Y. Im¹, S. Yeramaneni², Y. Yim³, J. Dodderer⁴, M. Askar¹, H. J. Huang⁵
¹Baylor University Medical Center, Dallas, TX, ²Baylor Scott & White Health, Dallas, TX, ³Ross University School of Medicine, Portsmouth, Dominica, ⁴Texas Tech University Health Sciences Center, El Paso, TX, ⁵Houston Methodist Hospital, Houston, TX
*Purpose: De novo donor specific antibodies (dnDSA) occur in up to 50% of lung transplant (LUTX) recipients within one year and are associated with increased…
2019 American Transplant Congress
Ex-Vivo Perfusion Mediated Delivery of Rituximab to Clear Latent Epstein-Barr Virus
T. Ku, M. Cypel, R. V. Ribeiro, V. H. Ferreira, D. Kumar, A. Humar
UHN, Toronto, ON, Canada
*Purpose: Post-transplant lymphoproliferative disorder (PTLD) can manifest as a B-cell malignancy associated with Epstein-Barr virus (EBV) infection. Risk of PTLD is greatest in EBV D+/R-…
2019 American Transplant Congress
Polymorphisms in Mycophenolate Mofetil Glucuronidation Gene Are Associated with Leukopenia and Decreased CLAD-Free Survival
A. Barnes, D. R. Calabrese, E. Henricksen, R. Florez, K. Dewey, P. Wang, J. Teraoka, K. Lien, S. Hays, J. P. Singer, J. Golden, J. Kukreja, J. R. Greenland
UCSF Medical Center, San Francisco, CA
*Purpose: Lung transplant recipients vary in their tolerance of the immunosuppressant mycophenolate mofetil (MMF). Single nucleotide polymorphisms (SNPs) in UDP-glucuronosyltransferase 2B7 (UGT2B7) increase conversion of…
2019 American Transplant Congress
Alteration in Local Complement Activation in First 24h Post-Lung Transplantation (LTx) Helps Identify Recipients Developing Primary Graft Dysfunction
H. Kulkarni¹, M. Elvington², L. Ma¹, M. Cano¹, K. Pugh³, R. Hachem¹, J. Atkinson², A. Gelman³
¹Pulmonary and Critical Care Medicine, Washington University, Saint Louis, MO, ²Rheumatology, Washington University, Saint Louis, MO, ³Surgery, Washington University, Saint Louis, MO
*Purpose: Primary graft dysfunction (PGD) is a form of acute lung injury driven by ischemia-reperfusion mediated damage. An increase in plasma complement proteins - specifically…