Articles tagged "Lung transplantation"

2019 American Transplant Congress
Concentric Circles, One Year in: Concentrated Organ Discard and Waitlist Deaths in High Traffic Areas
R. J. Lynch¹, S. Karp², W. Chapman³
¹Emory, Atlanta, GA, ²Vanderbilt, Nashville, TN, ³Washington University St. Louis, St. Louis, MO
*Purpose: Lung transplantation was the first organ system to entirely dispense with Donor Service Areas (DSAs) and Regions in favor of 250 nautical mile (NM)…
2019 American Transplant Congress
Caregiving before Thoracic Transplantation–A Qualitative Inquiry
C. C. Kennedy¹, J. Ridgeway¹, E. Stevens¹, J. Kirsch², K. Carroll¹, J. Griffin¹, R. Benzo¹
¹Mayo Clinic, Rochester, MN, ²University of Florida-Gainesville, Gainesville, FL
*Purpose: Although post-transplant caregiver (CG) support is a prerequisite for transplant listing, research shows CG outcomes including stress and social functioning may be worse during…
2019 American Transplant Congress
Pharmacist Impact on Vaccinations Rates in Cardiothoracic Transplant Recipients
K. Zaborowski, J. Dedering, R. Felkner
William S. Middleton Memorial Veterans Hospital, Madison, WI
*Purpose: The purpose of this project is to determine the impact pharmacists have on cardiothoracic transplant recipients’ vaccination status at the time of transplant surgery.*Methods:…
2019 American Transplant Congress
The Impact of Removing DSA as a First Unit of Lung Allocation: Preliminary Results
R. R. Lehman¹, K. Uccellini², M. Skeans³, M. Valapour³, E. D. Lease⁴, R. Daly⁵, K. M. Chan⁶
¹Research, United Network for Organ Sharing, Richmond, VA, ²Policy, United Network for Organ Sharing, Richmond, VA, ³SRTR, Minneapolis, MN, ⁴Univ of Washington, Seattle, WA, ⁵Mayo Clinic, Rochester, MN, ⁶Univ of Michigan, Ann Arbor, MI
*Purpose: In an emergency action on November 24, 2017 the Organ Procurement and Transplantation Network (OPTN) altered US lung allocation policy by replacing the donor…
2019 American Transplant Congress
Donate HCV Trial: Transplanting Thoracic Organs from Hepatitis C Donors to Uninfected Patients
A. E. Woolley¹, S. K. Singh², H. J. Goldberg³, M. M. Givertz⁴, M. R. Mehra⁴, A. Coppolino, III⁵, V. Cheng¹, J. Fanikos⁶, D. P. Harrington⁷, H. R. Mallidi², L. R. Baden¹
¹Infectious Diseases, Brigham and Womens Hospital, Boston, MA, ²Cardiac and Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ³Pulmonary, Brigham and Womens Hospital, Boston, MA, ⁴Cardiology, Brigham and Womens Hospital, Boston, MA, ⁵Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ⁶Pharmacy, Brigham and Womens Hospital, Boston, MA, ⁷Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Given the need for thoracic organs and the high mortality of patients awaiting heart or lung transplantation, it is imperative to find ways to…
2019 American Transplant Congress
Impact Of Inhaled Vasodilator Therapy On Early Morbidity And Mortality After Lung Transplant
M. Tomeczkowicz¹, A. Wexler¹, M. Patel², J. Fernandez-Castillo², J. Rusniak¹, E. Mancl³, S. Quddus²
¹Department of Pharmacy, Loyola University Medical Center, Maywood, IL, ²Division of Pulmonary and Critical Care, Loyola University Medical Center, Maywood, IL, ³Loyola University Medical Center, Maywood, IL
*Purpose: Within the first 72 hours of lung transplant, recipients may develop primary graft dysfunction (PGD). This complication is associated with acute and chronic rejection,…
2019 American Transplant Congress
Examination of a Novel Immunoregulatory Marker in Kidney and Lung Transplant Recipients
A. D. Desai¹, G. J. Kavalam², A. Chandraker², S. Tripathi²
¹1Harvard Summer Research Program for Kidney Medicine, Harvard Medical School,, Boston, MA, ²Schuster Family Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a co-inhibitory receptor mainly expressed on T cells and NK cells. TIGIT has…
2019 American Transplant Congress
The Frequency of Tissue-Resident Donor T and NK Cells in Peripheral Blood after Lung Transplantation is Modulated by Normothermic Ex Vivo Lung Perfusion
C. S. Falk¹, B. Wiegmann², A. Hitz¹, R. Bellmas-Sanz¹, K. Bläsing¹, F. Ius², C. Kühn², M. Avsar², I. Tudorache², J. Kühne¹, F. Wandrer¹, A. Haverich², G. Warnecke²
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: The appearance of passenger donor lymphocytes in recipient blood after double lung transplantation has been described decades ago. However, neither their early kinetics, nor…
2019 American Transplant Congress
Intact Lymphatics Are Essential for Costimulation Blockade-Induced Lung Allograft Survival
L. Wang¹, H. Reed², R. Han¹, M. Kahn², W. W. Hancock¹
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA
*Purpose: Blocking lymphangiogenesis is thought to diminish immune responses to donor tissues. However, lung transplantation (Tx), which involves airway and vascular but not lymphatic anastomoses,…
2019 American Transplant Congress
Outcomes for Lung Transplantation Recipients with Non-Alcoholic Fatty Liver Disease
A. J. Trindade¹, P. Burkett¹, S. El-Chemaly¹, N. Hashemi², T. Thaniyavarn¹, H. R. Mallidi³, H. J. Goldberg¹
¹Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ²Gastroenterology and Hepatology, Brigham and Women's Hospital, Boston, MA, ³Division of Thoracic and Cardiovascular Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Non-alcoholic Fatty Liver Disease (NAFLD) afflicts ~20-40% people in the western world and is a risk factor for comorbidities prevalent in the lung transplant…