Articles tagged "Lung transplantation"

2019 American Transplant Congress
Exosomes Isolated from Human Lung Transplant Recipients Diagnosed with Bronchiolitis obliterans Syndrome are Unique in Their Ability to Induce IL-6 via Rab27A Signaling Pathway
M. Rahman, M. Sharma, S. Angara, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Rab27, a member of the Rab subfamily of GTPases, has the ability to induce exosome secretion. Exosomes are small membrane vesicles (40-150nm) that regulate…
2019 American Transplant Congress
Lung Allocation Score Should Be Implemented in China
C. Ju, Q. Lian, B. Wei, X. Xu, R. Chen, J. He
State Key Lab of the Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou, China
*Purpose: Lung transplantation (LTx) is an effective treatment for patients with end stage of respiratory disease. Two of the major candidates are patients with chronic…
2019 American Transplant Congress
Unfavorable Donor after Cardiac Death Characteristics in Lung Transplantation: An Analysis of the UNOS Registry
A. Y. Choi¹, O. K. Jawitz², V. Raman², Y. Barac², M. S. Mulvihill², C. Moore², M. G. Hartwig²
¹Duke University School of Medicine, Durham, NC, ²Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Despite growing evidence that donation after circulatory death (DCD) lung transplants have comparable survival outcomes and primary graft dysfunction rates to donation after brain…
2019 American Transplant Congress
Transplanting Thoracic Organs From Hcv Donors To Uninfected Patients: Evaluation Of Lung Allografts
Y. Lo¹, R. F. Padera¹, H. R. Mallidi², H. J. Goldberg³, S. K. Singh², A. Coppolino, III⁴, L. R. Baden⁵, A. E. Woolley⁵
¹Pathology, Brigham and Womens Hospital, Boston, MA, ²Cardiac and Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ³Pulmonary, Brigham and Womens Hospital, Boston, MA, ⁴Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ⁵Infectious Diseases, Brigham and Womens Hospital, Boston, MA
*Purpose: Prior to the development of direct acting antiviral (DAA) therapy for hepatitis C virus (HCV), there was concern that patients who received lungs from…
2019 American Transplant Congress
Recipient Monocytes Activated by Endobronchial Toll-Like Receptor 2 Agonist Prevent Tolerance Induction after Lung Transplantation
S. Tanaka¹, J. M. Gauthier¹, Y. Terada¹, T. Takahashi¹, W. Li¹, R. Higashikubo¹, A. Y. Tong¹, V. Puri¹, A. S. Krupnick², A. E. Gelman¹, D. Kreisel¹
¹Department of Surgery, Washington University in St. Louis, St. Louis, MO, ²Department of Surgery, The University of Virginia, Charlottesville, VA
*Purpose: Extended criteria lung donors are being increasingly utilized, raising the possibility of transplanting lungs with a pre-existing pneumonia; how donor pneumonia alters alloimmune responses,…
2019 American Transplant Congress
Assessment Of Glomerular Filtration Rate Among Lung Transplant Candidates
S. Akkina¹, S. Hou², D. Jain Arwindekar², A. Desai²
¹Loyola University Medical Center, Maywood, IL, ²Medicine, Loyola University Medical Center, Maywood, IL
*Purpose: Assessment of kidney function in lung transplant candidates is difficult due to cachexia prior to transplant. Measured glomerular filtration rate (GFR) studies are useful…
2019 American Transplant Congress
Listing Practices and Graft Utilization Lag behind Supply of Hepatitis C Positive Deceased Donors for Liver and Kidney Transplant
C. E. Kling¹, J. D. Perkins², S. W. Biggins³, C. Johnson⁴, A. P. Limaye⁵, L. Sibulesky¹
¹Division of Transplant Surgery, University of Washington Medical Center, Seattle, WA, ²Division of Transplant Surgery and Clinical and Bio-Analytics Transplant Laboratory, University of Washington Medical Center, Seattle, WA, ³Divisions of Gastroenterology and Hepatology and Center for Liver Investigation Fostering DiscovEry, University of Washington Medical Center, Seattle, WA, ⁴Division of Nephrology, University of Washington Medical Center, Seattle, WA, ⁵Division of Infectious Disease, University of Washington Medical Center, Seattle, WA
*Purpose: The opioid epidemic resulted in increasing incidence of hepatitis C (HCV) in the general population and more deceased organ donors with HCV in the…
2019 American Transplant Congress
Circulating Exosomes Isolated from Human Lung Transplant Recipients with Respiratory Viral Infections Contain Nucleic Acids Specific to Virus and Can Lead to Activation of Stress Proteins
S. Bansal, R. Bremner, M. Smith, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Exosomes are membrane vesicles released by cells into body fluids. Our laboratory demonstrated the presence of circulating exosomes with lung self-antigens (SAgs), Collagen V…
2019 American Transplant Congress
A Randomized Pilot Trial of Home-Based Physical Activity Plus Dietary Intervention to Improve Physical Function in Patients with Advanced Liver Disease
H. Chen¹, A. A. Ferrando², M. G. White², M. Pauly², T. Bartter², M. A. Dunn¹, W. R. Kim³, A. Duarte-Rojo¹
¹T.E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Arkansas for Medical Sciences, Little Rock, AR, ³Stanford University, Palo Alto, CA
*Purpose: Deconditioning and frailty are prevalent among liver transplant (LTx) candidates and prehabilitation programs have been proposed in order to improve clinical outcomes. However, few…
2019 American Transplant Congress
The Molecular Features of Chronic Lung Allograft Dysfunction (CLAD) in Transbronchial and Endobronchial Mucosa Biopsies
M. D. Parkes¹, K. M. Halloran¹, J. Chang², P. F. Halloran and the INTERLUNG study group¹
¹University of Alberta, Edmonton, AB, Canada, ²ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD), the major long-term problem in lung transplantation, requires new strategies for prevention and management. However, CLAD is infrequently diagnosed…