Articles tagged "Lung transplantation"

2020 American Transplant Congress
Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats
H. Lin¹, S. Dai², W. Liu³, X. Lin², B. Yu², S. Chen³, S. Liu², J. Tang²
¹Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, ²Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, ³Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
*Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
2019 American Transplant Congress
Lung Transplant Outcomes after CABG
S. Huddleston¹, R. Aggarwal¹, S. Jackson², N. Lemke¹
¹Surgery, University of Minnesota, Minneapolis, MN, ²Surgery, Fairview Health Services, Minneapolis, MN
*Purpose: Prior coronary artery bypass grafting (CABG) has been a contraindication to lung transplantation (LTx) due to increased mortality associated with bilateral lung transplant. We…
2019 American Transplant Congress
Circulating Donor T and NK Cells in Lung Transplantation Recipients Are Derived from the Donor Lung Parenchyma and Represent Tissue-Resident Memory Cells
J. F. Kuehne¹, R. Ballmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. A. Bläsing¹, F. Ius², A. Knoefel², I. Tudorache², M. Avsar², D. Jonigk³, A. Haverich², G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School (MHH), Hannover, Germany, ³Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany
*Purpose: We previously identified donor lymphocytes in peripheral blood of recipients directly after transplantation and persisting at least three weeks that were characterized by the…
2019 American Transplant Congress
Molecular Features of Rejection in Endobronchial Mucosa Biopsies
M. D. Parkes, K. M. Halloran, J. Chang, P. F. Halloran and The INTERLUNG Study Group
University of Alberta, Edmonton, AB, Canada
*Purpose: Mucosal biopsies are safer and easier to collect than transbronchial biopsies (TBB) but cannot be assessed histologically for lung rejection. Reliable assessment would change…
2019 American Transplant Congress
Effect of Donor-Recipient Serologic CMV Matching on 1-Year Post-Lung Transplant Outcomes
H. Ehrenfeld, M. Manson, R. Yau
Pharmacy, CHI St. Luke's Health Baylor St. Luke's Medical Center, Houston, TX
*Purpose: Cytomegalovirus (CMV) poses significant risks and complications in solid organ transplant (SOT) patients. The current CMV guidelines acknowledge CMV serologic mismatch transplants contribute to…
2019 American Transplant Congress
Center Variability in Organ Offer Acceptance and Waitlist Mortality in Lung Transplantation
A. Y. Choi¹, M. S. Mulvihill², J. Weber³, H. Lee³, M. Cox², B. Yerokun², M. Kuchibhatla³, J. A. Klapper², M. G. Hartwig²
¹Duke University School of Medicine, Durham, NC, ²Department of Surgery, Duke University Medical Center, Durham, NC, ³Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC
*Purpose: Lung transplantation (LTx) offers a survival benefit for patients with end-stage lung disease. When suitable donors are identified, centers must accept or decline the…
2019 American Transplant Congress
Total Parenteral Nutrition in Ex Vivo Lung Perfusion: Addressing Metabolism Improves Both Inflammation and Overall Graft Performance
M. T. Buchko, S. Hatami, C. J. Stewart, S. Himmat, D. H. Freed, J. Nagendran
Department of Surgery, Division of Cardiac Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Contemporary clinical ex vivo lung perfusion (EVLP) protocols generally limit metabolic supplementation to insulin and glucose. Furthermore, conventional perfusates are void of many ingredients…
2019 American Transplant Congress
Cellular And Molecular Characteristics Of Intra-graft Lymphoid Aggregates In Chronic Lung Allograft Dysfunction
E. Miyamoto¹, S. Juvet¹, D. Hwang², S. Keshavjee¹, T. Martinu¹
¹Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada, ²Sunnybrook Health Sciences Centre, Toronto, ON, Canada
*Purpose: Lymphoid aggregates (LAs) have been identified within lung allografts post lung transplant (LTx). However, it remains controversial whether they represent benign lymphoid tissue or…
2019 American Transplant Congress
Clinical Outcomes of Using mTOR Inhibitors with Reduced Dose of Calcineurin Inhibitors in Lung Transplant Recipients: A Single Center Experience
M. Frawley¹, J. Leedy¹, A. James¹, A. Salter¹, V. Rusanov²
¹Department of Pharmacy, UAB Hospital, Birmingham, AL, ²Division of Pulmonary, Allergy, and Critical Care Medicine, UAB Hospital, Birmingham, AL
*Purpose: The use of mammalian target of rapamycin inhibitors (mTORi) in cardiothoracic transplantation has significantly increased over the past decade. Several recent clinical trials have…
2019 American Transplant Congress
Assessment of Physical Frailty is Positively Correlated with LAS Score in Lung Transplant Candidates
S. Jaladanki¹, L. Shih¹, O. Kwon², N. Ventigan², D. Nanayakkara², S. Weigt³, J. Singer⁴, A. Ardehali¹, R. Biniwale¹, D. Goldwater⁵, J. Schaenman²
¹Department of Cardiac Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Division of Pulmonary and Critical Care, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Division of Pulmonary and Critical Care, UCSF School of Medicine, San Francisco, CA, ⁵Division of Geriatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: We proposed to evaluate physical frailty in lung transplant candidates to determine whether physical frailty correlated with LAS score and added to ability to…