Articles tagged "Lung transplantation"

2020 American Transplant Congress
Impact of the 2015 LAS Revisions on Lung Candidates with Pulmonary Vascular Disease
K. Lindblad¹, R. Goff¹, K. Chan²
¹UNOS, Richmond, VA, ²University of Michigan, Ann Arbor, MI
*Purpose: On February 19, 2015 a major revision to the Lung Allocation Score (LAS) was implemented with the goal of more accurately reflecting waitlist urgency…
2020 American Transplant Congress
Incidence of Non-Tuberculous Mycobacteria in the Transplant Population at a University Transplant Center in Northern Florida
D. Schain, Z. Breslow, G. El Helou, A. Cannella
Medicine/IDGM, Univ of Florida, College of Med, Gainesville, FL
*Purpose: Over the past decade, there has been an increase in the number of non-tuberculous mycobacteria (NTM) infections in the United States, especially in the…
2020 American Transplant Congress
The Ratio between Naïve and Memory B Cells is Associated with Development of Early Donor-Specific Antibodies within the First Month after Lung Transplantation
A. Hitz¹, R. Bellmàs Sanz¹, F. Ius², J. Kühne¹, B. Wiegmann², W. Sommer², J. Salman², T. Siemeni², C. Kühn², M. Avsar², A. Haverich², I. Tudorache², G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany
*Purpose: After lung transplantation (LuTx), the development of early donor HLA-specific antibodies (eDSA) has been shown to be associated with antibody-mediated rejection (AMR) and poor…
2020 American Transplant Congress
Outcome Implications of Prescription Opioid and Benzodiazepine in Lung Transplant Patients: Analysis of Linked Registry and Pharmacy Claims Data
K. Lentine¹, L. Myaskovsky², H. Bruschwein³, M. Dew⁴, Z. Zhang¹, M. McAdams Demarco⁵, D. Segev⁵, D. Axelrod⁶, G. Hess⁷, B. Kasiske⁸, J. Snyder⁸, M. Schnitzler⁹
¹Department of Medicine, Saint Louis University, Saint Louis, MO, ²Univ of New Mexico, Albuquerque, NM, ³Univ of Virginia, Charlottesville, VA, ⁴Univ of Pittsburgh, Pittsburgh, PA, ⁵Johns Hopkins, Baltimore, MD, ⁶Univ of Iowa, Iowa City, IA, ⁷Drexel University, Philadelphia, PA, ⁸SRTR, Minneapolis, MN, ⁹Saint Louis University, Saint Louis, MO
*Purpose: To investigate the frequency, correlates, and outcomes associated with prescription opioid and benzodiazepine use before and after lung transplant (LuTx).*Methods: We examined a linkage…
2020 American Transplant Congress
Co-Stimulatory Blockade Immunosuppression Facilitates Lung Allograft Acceptance Through an Increase in Local IL-5 Production by Type 2 Innate Lymphoid Cells
Y. Guo, Z. Mei, A. Hata, B. Mahgoub, D. Li, A. Manafi, A. Banerjee, A. Gelman, D. Kreisel, A. Krupnick
Surgery, University of Virginia, Charlottesville, VA
*Purpose: We have recently demonstrated that co-stimulatory blockade (CSB)-induced mouse lung allograft acceptance depends on a rapid influx of eosinophils that function to downregulate T…
2020 American Transplant Congress
Monitoring the Removal of Donation Service Area from Lung Allocation
R. R. Goff¹, R. Daly², E. D. Lease³
¹Research, United Network for Organ Sharing, Richmond, VA, ²Mayo Clinic, Rochester, MN, ³University of Washington, Seattle, WA
*Purpose: In 2017 the Organ Procurement and Transplantation Network (OPTN) altered US lung allocation policy by replacing the donor service area (DSA) with a 250…
2020 American Transplant Congress
Has Every Possible Life Been Saved?: Rummaging Through the Discard Heap
A. L. Friedman, E. Marquez
LiveOnNY, NY, NY
*Purpose: To determine the reasons that deceased donor organs were allocated but not transplanted (TXP) in a large organ procurement organization (OPO).*Methods: All organs allocated…
2020 American Transplant Congress
Development and Impact of DSA after Lung Transplant
M. Henderson¹, G. Morris², C. Burt¹, A. Feist¹, J. Kozuch¹, E. Schonhoft³, G. Yung³, T. Floreth³, K. Afshar³, E. Golts⁴, M. Mariski¹
¹Pharmacy, University of California San Diego Health, San Diego, CA, ²Immunology, University of California San Diego Health, San Diego, CA, ³Pulmonology, University of California San Diego Health, San Diego, CA, ⁴Cardiothoracic Surgery, University of California San Diego Health, San Diego, CA
*Purpose: Antibody-mediated rejection (AMR) after lung transplant (LT) is a serious complication, potentially leading to graft failure despite advances in drug therapy. Diagnosis and treatment…
2020 American Transplant Congress
Medication Adherence in Thoracic Transplant Candidates
K. Pennington¹, R. Benzo¹, S. Jowsey¹, M. Budev², S. Chandreashekaran³, D. Erasmus⁴, E. Lease⁵, D. Levine⁶, K. Thompson¹, D. Yip⁴, B. Hardaway⁷, S. Dunlay¹, C. Kennedy¹
¹Mayo Clinic, Rochester, MN, ²Cleveland Clinic Foundation, Cleveland, OH, ³University of Florida, Gainesville, FL, ⁴Mayo Clinic, Jacksonville, FL, ⁵University of Washington, Seattle, WA, ⁶University of Texas Health Science Center, San Antonio, TX, ⁷Mayo Clinic, Scottsdale, AZ
*Purpose: Medication non-adherence is associated with poor outcomes in transplant recipients. It can be challenging to identify candidates at risk for medication non-adherence. The simplified…
2020 American Transplant Congress
Invasive Aspergillosis in Lung Transplant Recipients with Aspergillus Colonization Beyond One Year after Transplant
S. Davoudi, A. Pérez-Cortés Villalobos, T. Martinu, J. Tikkanen, D. Kumar, A. Humar, L. G. Singer, S. Keshavjee, S. Husain
University Health Network, Toronto, ON, Canada
*Purpose: Antifungal prophylaxis is recommended for Aspergillus colonization within a year in lung transplant recipients (LTRs) to prevent invasive aspergillosis (IA). However, the rate of…