Articles tagged "Lung transplantation"

2020 American Transplant Congress
Perioperative Results of Lung Transplantation in a Newly Established, High-Volume Lung Transplantation Center in China
F. Xiao¹, Z. Zhang¹, H. Feng¹, M. Li², W. Chen³, C. Liang¹, J. Chen³
¹Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, China, ²Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China, ³Department of Lung Transplantation, China-Japan Friendship Hospital, Beijing, China
*Purpose: The number of patients with end-stage lung disease is huge in China, lung transplantation is the only effective method. By presenting the perioperative results…
2020 American Transplant Congress
Evolution of Molecular Lung Transplant Biopsy Assessment: Rejection Can be Detected in Mucosal as Well as Transbronchial Biopsies
M. D. Parkes¹, K. Halloran², P. Halloran², &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: We recently developed a Molecular Microscope® (MMDx) rejection assessment platform for mucosal biopsies from the third airway bifurcation (3BMB) and transbronchial biopsies (TBB) from…
2020 American Transplant Congress
Risk Aversion in Lung Transplantation: Organ Procurement Organizations Differ in Willingness to Pursue Non-Ideal Donor Organs
S. E. Halpern¹, A. McConnell², S. Peskoe², V. Raman³, O. K. Jawitz³, A. Y. Choi¹, J. C. Haney³, J. A. Klapper³, M. G. Hartwig³
¹Duke University School of Medicine, Durham, NC, ²Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, ³Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Lungs from non-ideal deceased donors are disproportionally discarded despite evidence that waitlisted candidates benefit from use of these organs. Organ procurement organizations (OPOs) individually…
2020 American Transplant Congress
Amiodarone Use in Lung Transplant Recipients with New Onset Atrial Arrhythmias
E. Klipsch¹, R. Rachwan², I. KutKut³, D. Roe², C. Hage², T. Hathaway¹, R. S. Mangus²
¹Indiana University School of Medicine, Indianapolis, IN, ²IU Health, Indianapolis, IN, ³New York Presbyterian Hospital, New York, NY
*Purpose: Atrial arrhythmias occur in 16-46% of patients after lung transplant, and most of these are atrial fibrillation or flutter. Standard therapy is described as…
2020 American Transplant Congress
Association between Pre-Transplant Frailty and Increased Length of Stay after Lung Transplantation
J. Schaenman, N. Ventigan, J. Huang, S. Jaladanki, L. Shih, S. Gee, D. Sayah, S. S. Weigt, A. Ardehali, R. Biniwale, D. Goldwater
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Given the growing numbers of older lung transplant candidates, there has been increasing interest in using frailty assessment for risk stratification of transplant candidates.…
2020 American Transplant Congress
Association of Discharge Immunosuppressive Regimen with Treated Acute Rejection and Bronchiolitis Obliterans Syndrome in Adult Lung Transplantation: An Analysis of Organ Procurement and Transplantation Network Data
W. S. Cherikh¹, B. J. Plucinski¹, S. Palmer², W. E. Fitzsimmons³
¹United Network for Organ Sharing, Richmond, VA, ²Duke University Hospital, Durham, NC, ³Fitzsimmons LLC, Vernon Hills, IL
*Purpose: The optimal immunosuppressive (IS) regimen after lung (LU) transplant is unknown. We conducted the current analysis to compare the effect of four different discharge…
2020 American Transplant Congress
Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats
H. Lin¹, S. Dai², W. Liu³, X. Lin², B. Yu², S. Chen³, S. Liu², J. Tang²
¹Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, ²Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, ³Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
*Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
2020 American Transplant Congress
Overcoming Ab-Mediated Xenolung Rejection: Beta4Gal is an Important Pre- and Post-Transplant Ab Target, Relevant to Xenograft Injury in Baboons
L. Burdorf¹, Z. Abady¹, B. Cerel¹, K. Petitpas¹, C. Laird², S. Pratts¹, X. Cheng², C. J. Phelps³, W. Eyestone³, D. L. Ayares³, R. N. Pierson III¹, A. M. Azimzadeh¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Surgery, University of Maryland, Baltimore, MD, ³Revivicor, Blacksburg, VA
*Purpose: Knock-out (KO) of porcine carbohydrates (CHO), including Gal 1,3αGal, inhibits antibody-mediated xenograft rejection. The β4Gal epitope was discovered using serum from xenograft-sensitized baboons, but…
2020 American Transplant Congress
Accelerated Bronchiolitis Obliterans after Lung Transplant Promoted by the ATG16L1 rs2241880 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-Derived Alveolar Macrophages
M. Cano¹, D. Zhou², D. Kreisel³, C. Chen⁴, K. Pugh², D. Byers¹, R. Hachem¹, A. E. Gelman³
¹Pulmonary and Critical Care, Washington University, Saint Louis, MO, ²Surgery, Washington University, Saint Louis, MO, ³Surgery and Pathology and Immunology, Washington University, Saint Louis, MO, ⁴Pulmonary and Critical Care, Southwestern Medical Center, Dallas, TX
*Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood and require…
2020 American Transplant Congress
Outpatient Treatment of Paramyxovirus with Oral Ribavirin is Safe and Effective in Lung Transplant Recipients
A. W. Rogers¹, B. J. Pierce¹, C. Pham¹, J. T. Swan¹, H. J. Huang²
¹Department of Pharmacy, Houston Methodist Hospital, Houston, TX, ²Department of Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: Respiratory paramyxovirus infections present an increased risk to lung transplant recipients (LTRs), including rapid decline in graft function and immunologic sequelae such as rejection…