Articles tagged "Lung transplantation"

2021 American Transplant Congress
Alpha 1-antitrypsin Reduces Cytokine Elaboration in a Xenogeneic Lung Transplantation Model
L. Burdorf¹, C. Laird², T. Zhang², M. R. Connolly¹, Z. Habibabady¹, S. Pratts¹, S. Miura¹, F. Pollok¹, W. Eyestone³, C. J. Phelps³, D. L. Ayares³, A. M. Azimzadeh¹, R. N. Pierson III¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Surgery, University of Maryland, Baltimore, MD, ³Revivicor, Blacksburg, VA
*Purpose: Novel gene editing techniques have facilitated the generation of donor pigs with multiple genetic modifications, used for xenolung transplantation. Several rejection pathways, including antibody…
2021 American Transplant Congress
A Case-Match Cohort Comparison of the Safety and Efficacy of Basiliximab for Immunosuppression Holiday in Lung Transplant Patients
M. M. Eiting¹, J. E. Clark¹, T. L. Astor², J. Palafox², C. Rogers Marks¹, G. Waldman¹
¹Pharmacy, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA
*Purpose: Post-transplant complications related to calcineurin inhibitors (CNI) maintenance immunosuppression (MI) may require interim alternative therapies. The goal of this study is to evaluate the…
2021 American Transplant Congress
Accounting for Survivor Bias in Transplant Benefit Models
E. M. Schnellinger¹, E. Cantu², M. O. Harhay¹, D. E. Schaubel¹, S. E. Kimmel¹, A. J. Stephens-Shields¹
¹Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Department of Surgery, Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: The lung allocation system in the U.S. prioritizes lung transplant candidates based on estimated pre- and post-transplant survival. However, these models do not account…
2020 American Transplant Congress
Circulatory Extracellular Vesicles from Lung Allograft Recipients with Chronic Lung Allograft Dysfunction Can Induce LKB1 Dependent Epithelial-Mesenchymal Transition
M. Rahman, S. Angara, A. Arjuna, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Extracellular vesicles (EVs) play important role in physiological and pathological conditions. Recently we demonstrated that circulating exosomes (EVs) with lung self-antigens (SAgs) play important…
2020 American Transplant Congress
Improved Platelet Sequestration with Humanization of Von Willebrand Factor in Pig Xenogeneic Lung Perfusion Model
M. R. Connolly¹, L. Burdorf¹, Z. Abady¹, S. Sendil², E. Redding², B. Cerel¹, S. Pratts¹, C. Phelps³, W. Eyestone³, D. Ayares³, A. Azimzadeh¹, R. N. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²University of Maryland, Baltimore, Baltimore, MD, ³Revivicor, Blacksburg, VA
*Purpose: Von Willebrand factor (vWF) is an important element of hemostasis and when activated, mediates platelet adhesion and promotes platelet aggregation under shear stress conditions.…
2020 American Transplant Congress
A Large Animal Model of Ex-Vivo Lung Perfusion as a Platform to Deliver Therapeutic Agents to Lungs Before Lung Transplant
T. M. Egan¹, B. Haithcock¹, M. H. Ali¹, J. W. Blackwell¹, B. Masuodi¹, S. Shipley², T. Long³, A. Akerman¹, S. Montgomery⁴, H. Yuan⁵, P. Stewart⁶, J. Potenziano⁷, C. Sekaran⁷, R. Fitch⁷
¹Surgery, UNC at Chapel Hill, Chapel Hill, NC, ²Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, ³Pathology and Laboratory Medicine,, UNC at Chapel Hill, Chapel Hill, NC, ⁴Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, ⁵Radiology, UNC at Chapel Hill, Chapel Hill, NC, ⁶Gillings Global School of Public Health, UNC at Chapel Hill, Chapel Hill, NC, ⁷Mallinckrodt Pharmaceuticals, Hazelwood, MO
*Purpose: Ex-vivo lung perfusion (EVLP) has been used to evaluate lung function before lung transplant (LT). We used EVLP to expose lungs recovered 6 hours…
2020 American Transplant Congress
What’s Lung Got to Do with It?: The Impact of the 2017 Lung Allocation Policy at a Single Organ Procurement Organization
A. J. Boyer, J. B. Nave, C. A. Hostetler, C. C. Muse, R. A. Squires, J. P. Orlowski
LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK
*Purpose: To describe the impact of the lung allocation change on a single organ procurement organization (OPO). The allocation change took place on 11/24/2017 and…
2020 American Transplant Congress
Incidence and Influencing Factors of Venous Thromboembolism after Lung Transplantation
L. Fan¹, J. Chen², B. Wu¹, Z. Zhai³
¹Pulmonary and Critical Care Medicine, Wuxi People’s Hospital, Wuxi, China, ²Thoracic Surgery, Wuxi People’s Hospital, Wuxi, China, ³Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China
*Purpose: To analyze the incidence and influencing factors of venous thromboembolism (VTE) after lung transplantation.*Methods: This study retrospectively analyzed the clinical data of 375 lung…
2020 American Transplant Congress
Application of Image-Guidance Using 2D Illustrations and 3D Modeling of Donor Anatomy During Living Donor Hepatectomy
M. Lim, S. Kim, K. Kim, O. Lee, J. Kwon, E. Jeong, J. Yang, G. Choi
Transplantation, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: For living donor liver transplantation, preoperative imaging is required for the safety of donor and recipient. As we started our image-guidance program using 2D…
2020 American Transplant Congress
High Frequencies of Donor-Derived Memory T and NK Cells in the Blood of Lung Transplant Recipients May Contribute to Protection from Chronic Lung Allograft Dysfunction
R. Bellmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. Bläsing¹, F. Ius², W. Sommer², J. Kühne¹, L. Horn¹, A. Knöfel², I. Tudorache², A. Haverich², D. Jonigk³, G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany, ³Institute of Pathology, Hannover Medical School MHH, Hannover, Germany
*Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…