Articles tagged "Lung transplantation"

2021 American Transplant Congress
Mortality from Fulminant Myocarditis in Multi-organ Transplant Recipient with Covid-19
K. Mahendraraj, I. Kim, T. Todo, T. Brennan, N. Nissen, K. Kosari, G. Voidonikolas, D. Ramzy
Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Novel coronavirus infection has been rarely described in multi-organ transplantation. This case highlights the poor prognosis associated with cardiac involvement by SARS-Cov-2 in transplantation,…
2021 American Transplant Congress
A Molecular Classifier Identifies Antibody-Mediated Rejection-Associated Changes in Lung Transplant Biopsies
K. S. Madill-Thomsen¹, K. M. Halloran², M. Parkes¹, P. F. Halloran¹, &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Identifying lung transplant antibody-mediated rejection (ABMR) has been controversial. We compared gene expression in donor-specific antibody (DSA) positive vs. DSA negative lung transbronchial biopsies…
2021 American Transplant Congress
Basiliximab versus Alemtuzumab: The Association Between Induction Agent and Airway Complications Following Lung Transplantation
M. Furukawa¹, E. G. Chan¹, T. Harano¹, J. Ryan¹, R. Rivosecchi², M. R. Morrell¹, P. G. Sanchez¹
¹Cardiothoracic Surgery, UPMC, Pittsburgh, PA, ²PUH-Pharmacy, UPMC, Pittsburgh, PA
*Purpose: Controversy still exist regarding the best induction strategy for lung transplantation. At our institution, induction is defined based on donor recipient CMV match. While…
2021 American Transplant Congress
Perioperative Anidulafungin Combined with Triazole Prophylaxis for the Prevention of Early Invasive Candidiasis in Lung Transplant Recipients
E. Sartain¹, K. Schoeppler¹, B. Crowther¹, J. B. Smith², M. Abidi³, T. J. Grazia⁴, M. Steele², T. Gleason², K. Porter², A. Gray²
¹University of Colorado Skaggs School of Pharmacy, Aurora, CO, ²Division of Pulmonary Sciences and Critical Care, University of Colorado, Denver, CO, ³Division of Infectious Disease, University of Colorado, Denver, CO, ⁴Baylor University Medical Center, Dallas, TX
*Purpose: Invasive candidiasis (IC) is a substantial cause of morbidity and mortality in lung transplant recipients (LTRs). Post-operative factors, such as prolonged hospital stay, central…
2021 American Transplant Congress
Creating a Lung Transplant Program Search Tool Tailored to Patient Characteristics
W. T. McKinney¹, C. R. Schaffhausen¹, M. Bruin², S. Chu², J. Snyder³, M. Hertz⁴, M. Valapour⁵, B. Kasiske⁶, A. Israni¹
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²College of Design, University of Minnesota, Minneapolis, MN, ³Scientific Registry of Transplant Recipients, Minneapolis, MN, ⁴Medical School, University of Minnesota, Minneapolis, MN, ⁵Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, ⁶Nephrology, Hennepin Healthcare, Minneapolis, MN
*Purpose: Criteria for selecting lung transplant candidates and donors vary between programs and evolve as clinical practice advances. This variation impacts patient outcomes and the…
2021 American Transplant Congress
Molecular Classifiers for Chronic Lung Allograft Dysfunction Transbronchial and Mucosal Biopsies Predict Clinical CLAD and Graft Loss
M. D. Parkes¹, P. F. Halloran², K. M. Halloran³, &. the INTERLUNG Study Group⁴
¹Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³University of Alberta, Edmonton AB, AB, Canada, ⁴., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) portends poor outcomes yet is poorly understood. In the multi-center INTERLUNG study we measured transcripts in transbronchial biopsies (TBBs)…
2021 American Transplant Congress
Lung Transplant Recipients with Severe Acute Respiratory Syndrome-Coronavirus 2 Infection and Asymptomatic Carriers Waiting for Lung Transplantation Induce Circulating Exosomes with Severe Acute Respiratory Syndrome-Coronavirus 2 Spike Protein S2
S. Bansal, S. Tokman, T. Fleming, M. Smith, R. Bremner, T. Mohanakumar
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Exosomes are vesicles released by cells into body fluids. We demonstrated increased circulating exosomes with lung self-antigens (Collagen V, Kα1 Tubulin) and viral antigens…
2021 American Transplant Congress
COVID-19 Infection in Kidney versus Non-kidney Solid Organ Transplant Recipients: A Single Center Study
J. Schaenman¹, H. Byford², T. R. Grogan³, S. Fraschilla², K. Meneses⁴, J. C. Alejos⁵, M. Rivera⁶, S. Saab⁷
¹Infectious Diseases, UCLA, Los Angeles, CA, ²Transplant Administration, UCLA, Los Angeles, CA, ³Division of General Internal Medicine and Health Services Research, UCLA, Los Angeles, CA, ⁴Liver Transplantation, UCLA, Los Angeles, CA, ⁵Pediatric Heart Transplantation, UCLA, Los Angeles, CA, ⁶Pediatric Kidney Transplantation, UCLA, Los Angeles, CA, ⁷Liver Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: The COVID-19 pandemic has caused significant morbidity and mortality in patients around the world. A significant impact has been observed in immunocompromised patients such…
2021 American Transplant Congress
Evaluation of Pepsin in Bronchoalveolar Lavage Fluid Post-lung Transplantation: Implications of Detection
M. T. Olson, C. Rogers, K. McAnally, A. Arjuna
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: This preliminary investigation in three lung transplant recipients aimed to measure pepsin, as a marker of gastric microaspiration, in bronchoalveolar lavage fluid (BAL) fluid,…
2021 American Transplant Congress
Assessing the Accuracy of the Lung Allocation Score
N. Dussault¹, W. Parker¹, R. Jablonski¹, E. Garrity¹, M. Churpek²
¹University of Chicago, Chicago, IL, ²University of Wisconsin-Madison, Madison, WI
*Purpose: The Lung Allocation Score (LAS) relies on the performance of two cox proportional hazards models that estimate waitlist and post-transplant survival. These models were…