Articles tagged "Lung transplantation"

2021 American Transplant Congress
Single-cell Rna Sequencing of Latent Murine Cytomegalovirus Infected Lung Transplants
L. A. VanOsdol¹, S. Han¹, M. Kandpul², J. J. Wang¹, L. Qiu³, Z. J. Zhang¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Department of Surgery, Northwestern University, Chicago, IL, ³School of Medicine, University of California, San Fransisco, San Fransisco, CA
*Purpose: Analyze the transcriptomics of mouse lung cells with and without latent infection of cytomegalovirus (CMV) before and after transplantation and identify key cell types…
2021 American Transplant Congress
Postoperative Tracheostomy as a Predictor of Poor Clinical Outcomes in Lung Transplantation
E. C. Klipsch, T. J. Hathaway, D. Roe, C. Hage, M. Duncan, R. S. Mangus
Indiana University School of Medicine, Indianapolis, IN
*Purpose: Tracheostomies are commonly performed postoperatively in lung transplant recipients to provide ventilation for prolonged periods, and with relatively few studies detailing these patients’ outcomes…
2021 American Transplant Congress
20 Year Survival Following Lung Transplantation
R. M. Reul, Jr¹, S. Barrett¹, A. Alnajar², J. Dunson¹, P. S. Garcha³, G. Loor⁴, J. A. Goss⁴, A. A. Rana⁴
¹Office of Student Affairs, Baylor College of Medicine, Houston, TX, ²Department of Surgery, University of Miami Health System, Miami, FL, ³Department of Medicine, Baylor College of Medicine, Houston, TX, ⁴Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX
*Purpose: Outcomes following lung transplantation (LTx) have been poor compared to those of heart, liver, and kidney transplants, with 5-year survival rates around 50%. To…
2021 American Transplant Congress
Endothelial Glycocalyx Shedding is Associated with Graft Quality During Ex Vivo Lung Perfusion
K. Noda, B. J. Philips, T. Harano, J. D. Luketich, P. G. Sanchez
Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA
*Purpose: Endothelial glycocalyx is the surface protective layer of the endothelial cells and its damage is known to be strongly associated with organ dysfunction. However,…
2021 American Transplant Congress
Mortality from Fulminant Myocarditis in Multi-organ Transplant Recipient with Covid-19
K. Mahendraraj, I. Kim, T. Todo, T. Brennan, N. Nissen, K. Kosari, G. Voidonikolas, D. Ramzy
Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Novel coronavirus infection has been rarely described in multi-organ transplantation. This case highlights the poor prognosis associated with cardiac involvement by SARS-Cov-2 in transplantation,…
2021 American Transplant Congress
A Molecular Classifier Identifies Antibody-Mediated Rejection-Associated Changes in Lung Transplant Biopsies
K. S. Madill-Thomsen¹, K. M. Halloran², M. Parkes¹, P. F. Halloran¹, &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Identifying lung transplant antibody-mediated rejection (ABMR) has been controversial. We compared gene expression in donor-specific antibody (DSA) positive vs. DSA negative lung transbronchial biopsies…
2021 American Transplant Congress
Basiliximab versus Alemtuzumab: The Association Between Induction Agent and Airway Complications Following Lung Transplantation
M. Furukawa¹, E. G. Chan¹, T. Harano¹, J. Ryan¹, R. Rivosecchi², M. R. Morrell¹, P. G. Sanchez¹
¹Cardiothoracic Surgery, UPMC, Pittsburgh, PA, ²PUH-Pharmacy, UPMC, Pittsburgh, PA
*Purpose: Controversy still exist regarding the best induction strategy for lung transplantation. At our institution, induction is defined based on donor recipient CMV match. While…
2021 American Transplant Congress
Perioperative Anidulafungin Combined with Triazole Prophylaxis for the Prevention of Early Invasive Candidiasis in Lung Transplant Recipients
E. Sartain¹, K. Schoeppler¹, B. Crowther¹, J. B. Smith², M. Abidi³, T. J. Grazia⁴, M. Steele², T. Gleason², K. Porter², A. Gray²
¹University of Colorado Skaggs School of Pharmacy, Aurora, CO, ²Division of Pulmonary Sciences and Critical Care, University of Colorado, Denver, CO, ³Division of Infectious Disease, University of Colorado, Denver, CO, ⁴Baylor University Medical Center, Dallas, TX
*Purpose: Invasive candidiasis (IC) is a substantial cause of morbidity and mortality in lung transplant recipients (LTRs). Post-operative factors, such as prolonged hospital stay, central…
2021 American Transplant Congress
Creating a Lung Transplant Program Search Tool Tailored to Patient Characteristics
W. T. McKinney¹, C. R. Schaffhausen¹, M. Bruin², S. Chu², J. Snyder³, M. Hertz⁴, M. Valapour⁵, B. Kasiske⁶, A. Israni¹
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²College of Design, University of Minnesota, Minneapolis, MN, ³Scientific Registry of Transplant Recipients, Minneapolis, MN, ⁴Medical School, University of Minnesota, Minneapolis, MN, ⁵Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, ⁶Nephrology, Hennepin Healthcare, Minneapolis, MN
*Purpose: Criteria for selecting lung transplant candidates and donors vary between programs and evolve as clinical practice advances. This variation impacts patient outcomes and the…
2021 American Transplant Congress
Molecular Classifiers for Chronic Lung Allograft Dysfunction Transbronchial and Mucosal Biopsies Predict Clinical CLAD and Graft Loss
M. D. Parkes¹, P. F. Halloran², K. M. Halloran³, &. the INTERLUNG Study Group⁴
¹Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³University of Alberta, Edmonton AB, AB, Canada, ⁴., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) portends poor outcomes yet is poorly understood. In the multi-center INTERLUNG study we measured transcripts in transbronchial biopsies (TBBs)…

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