Articles tagged "Liver"

2017 American Transplant Congress
Porcine Albumin Elaboration During Perfusion of Transgenic Porcine Livers with Human Blood.
A. Cimeno,¹ J. Powell,¹ B. French,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III,¹ R. Barth,¹ J. LaMattina.
¹Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD; ²Revivicor, Inc., Blacksburg, VA
PurposeIn addition to immune barriers, molecular incompatibilities between species are predicted to limit pig liver survival in primate xenotransplantation models. How perfusion with human blood…
2017 American Transplant Congress
NAFLD in Kidney Transplant Candidates.
N. Kemmer, J. Buggs.
Tampa General Medical Group, Tampa, FL
Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause for liver transplant, and it is the most rapidly growing indication for simultaneous liver-kidney transplant…
2017 American Transplant Congress
Women Are Delisted for Being Too Sick for Liver Transplant More Frequently Than Men.
G. Cullaro, J. Lai.
University of California - San Francisco, San Francisco, CA
Background: Women (W) with cirrhosis awaiting liver transplantation (LT) experience higher rates of waitlist mortality than men (M). We aimed to understand the impact of…
2017 American Transplant Congress
The Adoption of Generic Immunosuppressant Medications Among Kidney and Liver Transplant Recipients Using the Colorado All Payer Claims Database.
Q. Liu,¹ A. Smith,¹ J. Park,² M. Oguntimein,³ S. Dutcher,³ G. Bello,¹ M. Helmuth,¹ M. Turenne,¹ R. Balkrishnan,⁴ M. Fava,¹ P. Sharma,² C. Beil,¹ A. Leichtman,¹ J. Zee.¹
¹Arbor Research Collaborative for Health, Ann Arbor, MI; ²U of Michigan, Ann Arbor, MI; ³Food and Drug Administration, Silver Spring, MD; ⁴U of Virginia, Charlottesville, VA
Background: Substitution of generic for brand-name immunosuppressants has increased in solid organ transplantation following the expiration of brand patents. Our aim was to describe the…
2017 American Transplant Congress
Polycystic Liver Disease Patients May Not Be Appropriately Represented by MELD Exception Policy.
S. Chandradas,¹ J. Waalen,² C. Frenette.¹
¹Organ Transplant, Scripps Clinic, La Jolla, CA; ²Scripps Translational Science Institute, La Jolla, CA
Purpose: Polycystic liver disease (PCLD) is a rare, but important disease whose mortality is not fully predicted by MELD score. Most patients with PCLD maintain…
2017 American Transplant Congress
Alcohol-Induced Hepatic Cirrhosis Is Rising Among Young Adults.
C. Kling,¹ J. Perkins,¹ D. Donovan,² R. Carithers,³ L. Sibulesky.¹
¹Division of Transplant Surgery, University of Washington, Seattle, WA; ²Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA; ³Division of Hepatology, University of Washington, Seattle, WA
Background: Alcoholic cirrhosis is a common indication for liver transplantation. Recent population studies have shown no change in the overall prevalence of alcohol use, but…
2017 American Transplant Congress
Impact of Inflammatory Bowel Disease on Survival and Risk of Retransplantation of Primary Sclerosing Cholangitis Patients Following Liver Transplantation: UNOS Data Analysis.
O. Mousa,¹ N. Patel,¹ J. Corral,¹ D. Lee,² J. Nguyen,² K. Croome,² D. Harnois.²
¹Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL; ²Transplant, Mayo Clinic, Jacksonville, FL
Background: The impact of inflammatory bowel disease (IBD) on outcomes after liver transplantation (LT) for primary sclerosing cholangitis (PSC) has been inconclusive. Previous reports suggested…
2017 American Transplant Congress
Graft and Patient Survival in Liver Transplantation for Primary Sclerosing Cholangitis with Organs from DCD versus DBD Donors: Analysis of the UNOS Database.
O. Mousa,¹ J. Corral,¹ M. Pang,¹ D. Lee,² J. Nguyen,² K. Croome,² D. Harnois.²
¹Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL; ²Transplant, Mayo Clinic, Jacksonville, FL
Background: Primary sclerosing cholangitis (PSC) remains a major indication for liver transplantation (LT) worldwide. In an era of limited organ donation pool, assessment of PSC…
2017 American Transplant Congress
Addition of hEPCR.hCD55.hTFPI.hCD47 Modulates Multi-Lineage Cell Sequestration and Coagulation Activation by GalTKO.hCD46 Transgenic Pig Livers Perfused Ex Vivo with Human Blood.
A. Cimeno,¹ L. Burdorf,¹ D. Parsell,¹ C. Phelps,² D. Ayares,² A. Azimzadeh,¹ R. Pierson III,¹ R. Barth,¹ J. LaMattina.¹
¹Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD; ²Revivicor, Inc., Blacksburg, VA
PurposeThe sequestration of multiple hematopoietic cell lineages and inappropriate coagulation cascade activation is associated with poor outcomes in multiple liver xenotransplant models. Here we evaluate…
2017 American Transplant Congress
Evaluation of Low Dose Valganciclovir for the Prevention of Cytomegalovirus in Liver Transplant Recipients.
C. Payne,¹ J. Melaragno,¹ D. Hutchinson,¹ T. Babu,² P. Prasad,^2,3 T. Dick.¹
¹Pharmacy, University of Rochester Medical Center, Rochester, NY; ²Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY; ³Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY
BACKGROUND: Cytomegalovirus (CMV) causes significant morbidity and mortality following orthotopic liver transplantation (OLT). Valganciclovir (VGCV) is used to prevent CMV, but at labeled doses can…