Articles tagged "Liver"

2017 American Transplant Congress
This is Why We Can't Have Nice Things- Real World Experience with Everolimus in Livers.
C. Perez,¹ J. Fleming,¹ M. Sell,¹ B. O'Brien,¹ A. Rogers,¹ I. Lee,¹ C. Mardis,¹ A. Mardis,¹ N. Patel,¹ H. Meadows,¹ N. Pilch,² K. Chavin,² D. Dubay,² D. Taber.²
¹Pharmacy, Medical University of South Carolina, Chareleston, SC; ²Surgery, Medical University of South Carolina, Charleston, SC
Purpose: To determine if discontinuation rates of everolimus (RAD) in clinical practice is higher than the 30% demonstrated in trials.Methods: This was a retrospective cohort…
2017 American Transplant Congress
Hepatic Ischemia Reperfusion Injury After Liver Transplantation Is Associated with Acute Kidney Injury.
S. Kubal,¹ M. Anderson,² J. Fridell,¹ B. Ekser,¹ T. Taber,² P. Li,¹ M. Ghabril,³ M. Lacerda,³ R. Mangus.¹
¹Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN; ²Department of Nephrology, Indiana University School of Medicine, Indianapolis, IN; ³Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN
Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. We hypothesized that severity of IRI correlates with…
2017 American Transplant Congress
Effects of the Gut-Liver Axis on Ischemia-Mediated Hepatocellular Carcinoma Recurrence in the Mouse Liver.
L. Orci,¹ S. Lacotte,¹ V. Delaune,¹ G. Oldani,¹ F. Slits,¹ C. Rossetti,² L. Rubbia-Brandt,³ P. Morel,¹ C. Toso.¹
¹Hepato-pancreato-biliary Centre, Department of Surgery, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; ²Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Varese, Italy; ³Division of Clinical Pathology, Department of Pathology and Immunology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Background: There is growing evidence that liver graft ischemia-reperfusion (I/R) is a risk factor for hepatocellular carcinoma (HCC) recurrence after liver transplantation, but the involved…
2017 American Transplant Congress
Health Literacy, Functional Status and Transplant Eligibility Among Adult Liver Transplant Candidates.
M. Serper, K. Dwinnells, M. Wolf, K. Olthoff.
University of Pennsylvania, Philadelphia; Northwestern University, Chicago
Introduction/Objectives: Low health literacy is associated with poor self-care in chronic diseases, however, is understudied in liver transplantation (LT). Study objectives were to evaluate associations…
2017 American Transplant Congress
Graft-versus-Host Disease Following Deceased Donor Liver Transplant.
K. Putchakayala, S. Skorupski, S. Farhan, M. Chaffins, S. Ilias, H. Pahari, K. Collins, S. Nagai, M. Abouljoud.
Henry Ford Hospital, Detroit, MI
We reviewed our institutional experience with graft-versus-host disease (GVHD) following orthotopic liver transplantation (OLT). All OLT from 10/1/2013-10/1/2016 were reviewed. Five cases of GVHD were…
2017 American Transplant Congress
Factors Associated with Death or Transplant in Low-MELD Patients.
A. Harper,¹ E. Edwards,¹ J. Heimbach.²
¹Research, UNOS, Richmond, VA; ²Surgery, Mayo Clinic, Rochester, MN
Background. The Model for End-stage Liver Disease (MELD) score is a good discriminator of 3-month mortality in patients awaiting a liver transplant. Previous research showed…
2017 American Transplant Congress
Histone Deacetylase Inhibition Mitigates Liver Ischemia/Reperfusion Injury in Mice.
D. Murken,¹ D. Aufhauser Jr,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ W. Hancock,² M. Levine.¹
¹Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
2017 American Transplant Congress
Platelets Stimulate Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6 During the Early Phase of Liver Regeneration in Mice.
J. Meyer,^1,2 E. Perroud,² P. Fontana,^3,4 K. Sadoul,⁵ P. Morel,^1,2 C. Gonelle-Gispert,² L. Bühler.^1,2
¹Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ²Unit of Surgical Research, University of Geneva, Geneva, Switzerland; ³Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland; ⁴Geneva Platelet Group, University of Geneva, Geneva, Switzerland; ⁵Institute for Advanced Biosciences, Inserm U1209, Grenoble, France
Background and aimsPlatelets and liver sinusoidal endothelial cells (LSEC) are known to both independently regulate liver regeneration. Our aim was to investigate the role of…
2017 American Transplant Congress
Life Threatening Disparities in Calculated MELD Due to Variation in Laboratory Methods within a UNOS Region.
E. Verna,¹ C. Connelly,¹ L. Dove,¹ J. Emond,¹ P. Adem,² N. Babic,³ J. Corsetti,⁴ J. Faix,⁵ J. Hayden,⁶ M. Lifshitz,⁷ M. Chiles,¹ S. Mohan,¹ H. Eldad,¹ A. Kratz.¹
¹CUMC, NY; ²WMC, NY; ³MSSM, NY; ⁴URMC, Rochester; ⁵MMC, NY; ⁶WCM, NY; ⁷NYU, NY
MELD was implemented as an objective measure to prioritize patients for liver transplant (LT). Accuracy and reproducibility of MELD is an essential assumption to ensure…
2017 American Transplant Congress
Isoflurane Precondition Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy.
Z. Rao,¹ H. Zhou,² X. Pan,¹ M. Gao,¹ Z. Wang,¹ J. Sun,¹ C. Liu,¹ Z. Ding.¹
¹Department of Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China; ²Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Isoflurane has a pharmacological precondition effect against ischemia injury in the heart, kidney and brain, but whether and how isoflurane precondition protects livers against…