ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver"

  • 2017 American Transplant Congress

    Effects of the Gut-Liver Axis on Ischemia-Mediated Hepatocellular Carcinoma Recurrence in the Mouse Liver.

    L. Orci,1 S. Lacotte,1 V. Delaune,1 G. Oldani,1 F. Slits,1 C. Rossetti,2 L. Rubbia-Brandt,3 P. Morel,1 C. Toso.1

    1Hepato-pancreato-biliary Centre, Department of Surgery, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; 2Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Varese, Italy; 3Division of Clinical Pathology, Department of Pathology and Immunology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland

    Background: There is growing evidence that liver graft ischemia-reperfusion (I/R) is a risk factor for hepatocellular carcinoma (HCC) recurrence after liver transplantation, but the involved…
  • 2017 American Transplant Congress

    Health Literacy, Functional Status and Transplant Eligibility Among Adult Liver Transplant Candidates.

    M. Serper, K. Dwinnells, M. Wolf, K. Olthoff.

    University of Pennsylvania, Philadelphia; Northwestern University, Chicago

    Introduction/Objectives: Low health literacy is associated with poor self-care in chronic diseases, however, is understudied in liver transplantation (LT). Study objectives were to evaluate associations…
  • 2017 American Transplant Congress

    Graft-versus-Host Disease Following Deceased Donor Liver Transplant.

    K. Putchakayala, S. Skorupski, S. Farhan, M. Chaffins, S. Ilias, H. Pahari, K. Collins, S. Nagai, M. Abouljoud.

    Henry Ford Hospital, Detroit, MI

    We reviewed our institutional experience with graft-versus-host disease (GVHD) following orthotopic liver transplantation (OLT). All OLT from 10/1/2013-10/1/2016 were reviewed. Five cases of GVHD were…
  • 2017 American Transplant Congress

    Factors Associated with Death or Transplant in Low-MELD Patients.

    A. Harper,1 E. Edwards,1 J. Heimbach.2

    1Research, UNOS, Richmond, VA; 2Surgery, Mayo Clinic, Rochester, MN

    Background. The Model for End-stage Liver Disease (MELD) score is a good discriminator of 3-month mortality in patients awaiting a liver transplant. Previous research showed…
  • 2017 American Transplant Congress

    Histone Deacetylase Inhibition Mitigates Liver Ischemia/Reperfusion Injury in Mice.

    D. Murken,1 D. Aufhauser Jr,1 S. Concors,1 Z. Wang,1 G. Ge,1 W. Hancock,2 M. Levine.1

    1Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA; 2Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA

    Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
  • 2017 American Transplant Congress

    Platelets Stimulate Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6 During the Early Phase of Liver Regeneration in Mice.

    J. Meyer,1,2 E. Perroud,2 P. Fontana,3,4 K. Sadoul,5 P. Morel,1,2 C. Gonelle-Gispert,2 L. Bühler.1,2

    1Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; 2Unit of Surgical Research, University of Geneva, Geneva, Switzerland; 3Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland; 4Geneva Platelet Group, University of Geneva, Geneva, Switzerland; 5Institute for Advanced Biosciences, Inserm U1209, Grenoble, France

    Background and aimsPlatelets and liver sinusoidal endothelial cells (LSEC) are known to both independently regulate liver regeneration. Our aim was to investigate the role of…
  • 2017 American Transplant Congress

    Life Threatening Disparities in Calculated MELD Due to Variation in Laboratory Methods within a UNOS Region.

    E. Verna,1 C. Connelly,1 L. Dove,1 J. Emond,1 P. Adem,2 N. Babic,3 J. Corsetti,4 J. Faix,5 J. Hayden,6 M. Lifshitz,7 M. Chiles,1 S. Mohan,1 H. Eldad,1 A. Kratz.1

    1CUMC, NY; 2WMC, NY; 3MSSM, NY; 4URMC, Rochester; 5MMC, NY; 6WCM, NY; 7NYU, NY

    MELD was implemented as an objective measure to prioritize patients for liver transplant (LT). Accuracy and reproducibility of MELD is an essential assumption to ensure…
  • 2017 American Transplant Congress

    Isoflurane Precondition Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy.

    Z. Rao,1 H. Zhou,2 X. Pan,1 M. Gao,1 Z. Wang,1 J. Sun,1 C. Liu,1 Z. Ding.1

    1Department of Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China; 2Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

    Background: Isoflurane has a pharmacological precondition effect against ischemia injury in the heart, kidney and brain, but whether and how isoflurane precondition protects livers against…
  • 2017 American Transplant Congress

    Toll-Like Receptor 4-Dependent CCAAT-Enhancer-Binding Protein Homologous Protein Activation Induces Hepatocellular Cell Death in Liver Ischemia and Reperfusion Injury.

    H. Zhou,1 Z. Rao,2 H. Wang,1 X. Wang,1 L. Lu.1

    1Department of Liver Surgery, First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China; 2Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

    Background: Critical role of Toll-like receptor 4(TLR4) and endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the relationship between…
  • 2017 American Transplant Congress

    MELD Exception Score: LSAM Modeling of a Fixed Floor.

    J. Heimbach,1 R. Hirose,2 D. Schladt,3 J. Pyke,3 J. Zeglin,3 S. Leppke,3 J. Lake,4 W. Kim.5,3

    1Mayo Clinic, Rochester; 2UCSF, San Francisco; 3SRTR, Minneapolis; 4Univ of Minnesota, Minneapolis; 5Stanford Univ, Stanford

    Current US liver allocation policy grants standard MELD score exceptions beginning at 22 points and rising every 3 months. Scores for hepatocellular cancer are delayed…
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