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Living Donor Liver Transplantation for Alcoholic Liver Disease.

H. Braun, J. Dodge, J. Roberts, N. Ascher.

University of California, San Francisco, San Francisco, CA

Meeting: 2017 American Transplant Congress

Abstract number: B232

Keywords: Alcohol, Liver

Session Information

Date: Sunday, April 30, 2017

Session Name: Poster Session B: Living Donors and Partial Grafts

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall D1

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The literature on living donor liver transplantation (LDLT) for alcoholic liver disease (ALD) is sparse. We report our experience w/LDLT for ALD at a single, high-volume US Center. Methods: Between 2002-2015, we analyzed recipients who underwent LDLT for ALD and compared this with non-ALD cohort using non parametric tests, Kaplan Meier curves. Results: 136 LDLT; 22 for ALD. For ALD: median age 55.5 yrs, 60% male, MELD 15.7, 73% R lobe grafts; 73% prior drug use, 41% prior tobacco, all had min sobriety 6 mos. 4 patients died; 6 lost grafts. 3 relapses: 1 alcohol, 1 tobacco, 1 lost to follow up. Tables 1 and 2 compare LDLT for ALD vs other indications.

ALD Non-ALD P-value
Age (years) 57.5 56.5 0.92
Height (cm) 176.6 167.8 0.03
Weight (kg) 85.3 76.4 0.05
BMI 27.3 26.3 0.37
MELD 15 16 0.68
HCC 4.6% 13.2% 0.47
Ascites pre-LT 77.3% 71.9% 0.61
Ascites at LT 13.6% 29.0% 0.14

No significant difference in graft fxn, LOS, biliary complications (Table 2), 1-or 5-year patient (Figure 1) or graft survival. (Figure 2) Conclusion: Excellent outcomes, low recidivism w/LDLT for ALD.

ALD Non-ALD P-value
Left lobe 27.3% 51.3% 0.035
Graft vol (cc) 675 600 0.26
SLV (cc) 1601.2 1492.3 0.05
Tbili (POD7) 3.7 3.4 0.94
Tbili (POD14) 2.0 2.6 0.67
INR (POD7) 1.4 1.3 0.37
INR (POD14) 2.0 1.1 0.19
LOS (days) 14 12 0.64
Biliary complication 45% 32% 0.13
Additional surgery 68.2% 37.7% 0.008
Time to additional surgery (days) 55 146 0.44

CITATION INFORMATION: Braun H, Dodge J, Roberts J, Ascher N. Living Donor Liver Transplantation for Alcoholic Liver Disease. Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Braun H, Dodge J, Roberts J, Ascher N. Living Donor Liver Transplantation for Alcoholic Liver Disease. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/living-donor-liver-transplantation-for-alcoholic-liver-disease/. Accessed January 19, 2021.

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