Living Donor Liver Transplantation for Alcoholic Liver Disease.
University of California, San Francisco, San Francisco, CA
Meeting: 2017 American Transplant Congress
Abstract number: B232
Session Information
Date: Sunday, April 30, 2017
Session Name: Poster Session B: Living Donors and Partial Grafts
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
The literature on living donor liver transplantation (LDLT) for alcoholic liver disease (ALD) is sparse. We report our experience w/LDLT for ALD at a single, high-volume US Center. Methods: Between 2002-2015, we analyzed recipients who underwent LDLT for ALD and compared this with non-ALD cohort using non parametric tests, Kaplan Meier curves. Results: 136 LDLT; 22 for ALD. For ALD: median age 55.5 yrs, 60% male, MELD 15.7, 73% R lobe grafts; 73% prior drug use, 41% prior tobacco, all had min sobriety 6 mos. 4 patients died; 6 lost grafts. 3 relapses: 1 alcohol, 1 tobacco, 1 lost to follow up. Tables 1 and 2 compare LDLT for ALD vs other indications.
| ALD | Non-ALD | P-value | |
| Age (years) | 57.5 | 56.5 | 0.92 |
| Height (cm) | 176.6 | 167.8 | 0.03 |
| Weight (kg) | 85.3 | 76.4 | 0.05 |
| BMI | 27.3 | 26.3 | 0.37 |
| MELD | 15 | 16 | 0.68 |
| HCC | 4.6% | 13.2% | 0.47 |
| Ascites pre-LT | 77.3% | 71.9% | 0.61 |
| Ascites at LT | 13.6% | 29.0% | 0.14 |
No significant difference in graft fxn, LOS, biliary complications (Table 2), 1-or 5-year patient (Figure 1) or graft survival. (Figure 2) Conclusion: Excellent outcomes, low recidivism w/LDLT for ALD.
| ALD | Non-ALD | P-value | |
| Left lobe | 27.3% | 51.3% | 0.035 |
| Graft vol (cc) | 675 | 600 | 0.26 |
| SLV (cc) | 1601.2 | 1492.3 | 0.05 |
| Tbili (POD7) | 3.7 | 3.4 | 0.94 |
| Tbili (POD14) | 2.0 | 2.6 | 0.67 |
| INR (POD7) | 1.4 | 1.3 | 0.37 |
| INR (POD14) | 2.0 | 1.1 | 0.19 |
| LOS (days) | 14 | 12 | 0.64 |
| Biliary complication | 45% | 32% | 0.13 |
| Additional surgery | 68.2% | 37.7% | 0.008 |
| Time to additional surgery (days) | 55 | 146 | 0.44 |
CITATION INFORMATION: Braun H, Dodge J, Roberts J, Ascher N. Living Donor Liver Transplantation for Alcoholic Liver Disease. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Braun H, Dodge J, Roberts J, Ascher N. Living Donor Liver Transplantation for Alcoholic Liver Disease. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/living-donor-liver-transplantation-for-alcoholic-liver-disease/. Accessed August 13, 2020.« Back to 2017 American Transplant Congress