ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver"

  • 2017 American Transplant Congress

    Neutering Worsens Liver Ischemia/Reperfusion Injury in Both Male and Female Mice.

    D. Murken,1 D. Aufhauser Jr,1 S. Concors,1 Z. Wang,1 G. Ge,1 W. Hancock,2 M. Levine.1

    1Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA; 2Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA

    Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
  • 2017 American Transplant Congress

    A Pilot Test of the "Individualized Self-Management Training in Adolescent/Young Adult Recipients of Transplantation (iSTART)" Program.

    E. Fredericks, S. Eder, D. Egleston, W. Newhouse, D. O'Reilly, G. Freed, J. Magee, K. Resnicow.

    University of Michigan, Ann Arbor

    Objective: To pilot test the feasibility and impact of the iSTART program on medication adherence, quality of life, and medication barriers among adolescent/young adult (AYA)…
  • 2017 American Transplant Congress

    PPAR-γ Agonist Attenuates Hepatic Ischemia-Reperfusion Injury in a Mouse Model by Regulating Kupffer Cell Polarization.

    I. Linares, K. Farrokhi, J. Echeverri, M. Kaths, D. Kollman, M. Hamar, P. Urbanellis, S. Ganesh, O. Adeyi, P. Yip, N. Selzner, M. Selzner.

    Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada

    PPAR-γ agonists have shown protective effect on ischemia-reperfusion injury (IRI) in cerebral and renal tissue. The effects of PPAR-γ on hepatic IRI is unclear. We…
  • 2017 American Transplant Congress

    Use of Ledipasvir/Sofosbuvir with or without Ribavirin in Patients Post-Liver Transplant: Evaluation of Real-World Datasets.

    S. Flamm,1 M. Charlton,2 M. Manns,3 M. Prieto,4 I. Fernandez,5 M. Londono,6 R. Kwok,7 C. Smith,8 S. Lee,9 H. Ngo,9 A. Osinusi,9 A. Copans,9 L. Rossaro,9 M. Shoreibah,10 O. Massoud,10 M. Curry,11 M. Bourliere.12

    1Northwestern University, Chicago; 2Intermountain Medical Center, Murray; 3Hannover Medical School, Hannover, Germany; 4Hospital Universitari I Politecnic La Fe, Valencia, Spain; 5Hospital Universitario 12 de Octubre, Madrid, Spain; 6Servicio de Hepatología. Hospital Clinic, Barcelona, Spain; 7Walter Reed National Military Medical Center, DC; 8Medstar Georgetown University Hospital, Georgetown; 9Gilead Sciences, Inc., Foster City; 10University of Alabama Birmingham, Birmingham; 11Beth Israel Deaconess Medical Center, Boston; 12Hospital Saint Joseph, Marsielle, France

    PURPOSE: Post-liver transplant(LT) patients with HCV are considered a difficult-to-treat population. Ledipasvir/sofosbuvir(LDV/SOF) +ribavirin(RBV) for 12 weeks is approved in GT1 LT recipients based on the…
  • 2017 American Transplant Congress

    Protective Effect of Crepidiastrum denticulatum Extract Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice.

    H. Jang, H. Lee, C. Park, D. Eom, J. Lee, M. Oh, J. Yoo, C. Rho.

    Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Anesthesia, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Pathology, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon, Korea; Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon, Korea

    Crepidiastrum denticulatum (CD) is a well-known, traditionally consumed vegetable in Korea, which was recently reported to have bioactive compounds with detoxification and antioxidant properties. Ischemia-reperfusion…
  • 2017 American Transplant Congress

    Biliary Complications in Pediatric Liver Transplantation for Cystic Fibrosis: A Single-Center Experience with Choledochocholedochostomy.

    P. Rizk, J. Moffett, M. Vu, R. Ackah, R. Sigireddi, M. Finegold, C. O'Mahony, A. Rana, J. Goss.

    Baylor College of Medicine, Houston, TX

    BackgroundFor adult liver transplants, choledochocholedochostomy or “duct-to-duct” biliary reconstruction is the standard of care. In contrast to a Roux-en-Y reconstruction, it maintains physiologic bile flow,…
  • 2017 American Transplant Congress

    Improved Preservation During Normothermic Ex-Vivo Liver Perfusion with Delta Opioid Agonist (D-Ala2, D-Leu5) Enkephalin (DADLE).

    E. Beal,1 J. Kim,1 D. Hayes Jr.,2 K. Washburn,1 B. Whitson,1 S. Black.1

    1Department of Surgery, Division of Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; 2Departments of Pediatrics and Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background: The metabolic demand of donor livers during prolonged normothermic ex-vivo perfusion with its associated oxygen stress is a challenge. Delta opioid agonist (D-Ala2, D-Leu5)…
  • 2017 American Transplant Congress

    A Multi-Center Experience of Direct Acting Anti-Viral Agents in HCV Positive Patients Receiving HCV Positive Livers.

    N. Kapila,1 B. Zervos,2 B. Ismail,1 C. Lindenmeyer,3 V. Sanghi,3 K. Menon,3 G. Schnickel,2 J. Rivas,2 D. Reino,2 A. Tzakis.2

    1Gastroenterology, Cleveland Clinic, Weston, FL; 2Transplant, Cleveland Clinic, Weston, FL; 3Gastroenterology, Cleveland Clinic, Cleveland, OH

    Background: HCV cirrhosis is the leading indication for liver transplantation in the U.S. The development of direct acting anti-viral agents (DAAs) has changed the approach…
  • 2017 American Transplant Congress

    Chronic Hepatitis E-Genotype 3 Infection in Transplant Recipients: A Single Kidney and Pancreas Transplant Centre Experience.

    A. Kousios,1 R. Charif,1 E. Sanchez,2 S. Khan,3 F. Regan,4 S. Ijaz,5 D. Muir,2 B. Smith,3 R. Tedder,5 D. Taube,1 J. Galliford.1

    1Renal and Transplant Centre, Imperial College NHS Trust, London, United Kingdom; 2Department of Infection and Immunity, Imperial College NHS Trust, London, United Kingdom; 3Department of Hepatology, Imperial College NHS Trust, London, United Kingdom; 4Department of Hematology, Imperial College NHS Trust, London, United Kingdom; 5Blood Borne Virus Unit, Virus Reference Department, MS-Colindale, Public Health England, London, United Kingdom

    Introduction:In the UK, Hepatitis E virus-genotype 3 (HEV3), is endemic and has now become the major cause of enterically transmitted viral hepatitis. Unlike HEV-genotype 1…
  • 2017 American Transplant Congress

    Ornithine Transcarbamylase Deficiency (OTC) in the Donor Liver, the Importance of Ascertaining the Cause of Death in the Brain Dead Donor.

    M. George,1 G. Thomas,1 A. Shun,1 M. Stormon.2

    1Paediatric Surgery and Transplant Surgery, Children's Hospital at Westmead, Sydney, NSW, Australia; 2Paediatric Gastroenterology, Children's Hospital at Westmead, Sydney, NSW, Australia

    The importance of ascertaining the cause of brain death in the donor is vital . We present a case of cadaveric liver donation (seg 2…
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