Articles tagged "Liver"

2018 American Transplant Congress
Gr1^– Macrophages Play Critical Roles in Liver Inflammation Resolution after IRI via Efferocytosis
M. Ni,^1,2 H. Wang,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu, China.
Inflammation resolution is an integral part of liver ischemia reperfusion injury (IRI), which affects not only the severity of tissue damage, but more importantly its…
2018 American Transplant Congress
Liver Allocation: One OPO's Experience with Expedited versus Non-Expedited Placement
C. Muse, R. Squires, C. Trahan, J. Whaley, J. Orlowski.
LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK.
Background: One organ procurement organization (OPO) sought to study expedited versus non-expedited livers recovered/transplanted after local/regional centers declined. The OPO sought to determine relative recipient…
2018 American Transplant Congress
Effects of Preformed Antibody on Survival Following Pig-to-Primate Liver Xenotransplantation
N. Louras, M. Patel, J. Shah, A. Andrews, Z. Wang, D. Sachs, P. Vagefi.
Transplant Surgery, Massachusetts General Hospital, Boston, MA.
Objectives:Xenotransplantation represents the best near-term solution to address the current organ shortage. We have developed a pre-clinical model of pig-to-primate liver xenotransplantation (LXT), and now…
2018 American Transplant Congress
TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion
S. Zhou, H. Zhou, R. Liu, F. Zhang, X. Wang, L. Lu.
Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…
2018 American Transplant Congress
MELD Based Allocation Deteriorates Patient Survival without Improving Waiting List Mortality in a Low Donor Area
P. Ritschl, L. Wiering, F. Aigner, M. Biebl, D. Eurich, M. Schmelzle, I. Sauer, K. Kotsch, J. Pratschke, R. Öllinger.
Department of Surgery, Campus Charité Mitte / Campus Virchow-Klinikum CCM/CVK, Charité - Universitätsmedizin Berlin, Berlin, Germany.
The MELD-based allocation system has been implemented in Germany in 2006 in order to decrease waiting list mortality in patients with end stage liver disease.…
2018 American Transplant Congress
Assessment of Bile Production and Quality during Normothermic Ex Vivo Liver Perfusion to Predict Biliary Injury
D. Kollmann,¹ I. Linares,¹ S. Ganesh,¹ R. Rosales,¹ M. Hamar,¹ P. Urbanellis,¹ A. Wiebe,¹ P. Yip,² O. Adeyi,² M. Selzner,¹ N. Selzner.¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, Canada; ²Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada.
Background. Liver transplantation (LT) with donation after circulatory death (DCD)-grafts is associated with higher risk for biliary strictures. We evaluated bile production and quality during…
2018 American Transplant Congress
DAP12 and Its Triggering Co-Receptor TREM2 Play Key Roles in Regulation of Mouse and Human Liver DC Function and Control of Liver Ischemia-Reperfusion Injury
T. Nakao,¹ Y. Ono,¹ H. Dai,¹ A. Perez-Gutierrez,¹ G. Camirand,¹ H. Huang,¹ D. Geller,^1,2 A. Thomson.^1,3
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Background: Liver interstitial dendritic cells (DCs) have been implicated in the control of liver ischemia/reperfusion injury (IRI) and in the induction of liver transplant tolerance.…
2018 American Transplant Congress
Double Deficiency of Gelatinase-A and Gelatinase-B Does Not Protect against Hepatic Ischemia Reperfusion Injury
S. Duarte, P. Matian, S. Ma, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles.
Gelatinases, consisting of gelatinase A (MMP-2; 72 KDa) and gelatinase B (MMP-9; 92KDa), are a subgroup of matrix metalloproteinases (MMPs) with key roles in a…
2018 American Transplant Congress
Umbilical Cords-Derived Mesenchymal Stem Cells Ameliorates Hepatic Ischemia-Reperfusion Injury via Activating the AMPK-mTOR/ULK1 Signaling Pathway Enhanced Autophagy
J. Zheng,^1,2 J. Cai,^1,2 L. Chen,^1,2 J. Yao,^1,2 K. Zeng,^1,2 H. Li,^1,2 Y. Zhang,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
UC-MSCs induction of anti-apoptosis has been indicated to play protective roles in liver ischemia-reperfusion (I/R) model. However, the exact molecular mechanisms of UC-MSCs in hepatic…
2018 American Transplant Congress
Normothermic Ex Vivo Liver Perfusion Prior to Liver Transplantation Can Prevent Platelet Aggregation and Platelet Induced Sinusoidal Cell Injury
D. Kollmann,¹ I. Linares,¹ S. Ganesh,¹ R. Rosales,¹ N. Tessandier,² E. Boilard,² M. Hamar,¹ P. Urbanellis,¹ P. Yip,³ O. Adeyi,³ M. Selzner,¹ N. Selzner.¹
¹Multi Organ Transplant, UHN, Toronto, Canada; ²Centre Hospitalier de l'Université Laval (CHUL), Québec, Canada; ³Laboratory Medicine and Pathobiology, UHN, Toronto, Canada.
Background. Normothermic ex vivo liver perfusion (NEVLP) is a novel method for graft-preservation applied alternatively to static cold storage (SCS). We examined the impact of…