ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver"

  • 2018 American Transplant Congress

    A Six-Month, Prospective, Single-Center, Pilot Study to Determine the Pharmacokinetics and Effectiveness of Immunosuppressant Regimens in Liver Transplantation Patients Receiving Twice-Daily Tacrolimus and Everolimus (TAC + EVR BID) Regimen Converted to Once-Daily Tacrolimus and Everolimus (TAC + EVR QD) Regimen – A Priliminary Report

    T-.H. Wu, C-.H. Cheng, Y-.C. Wang, C-.F. Lee, T-.J. Wu, H. Chou, K-.M. Chan, W-.C. Lee.

    Division of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan.

    Adherence to immunosuppressant regimen is crucial for graft survival and usually inversely related to the dose frequency. Similar efficacy and safety profile has been approved…
  • 2018 American Transplant Congress

    Glycogen Synthase Kinase 3 beta Regulates Liver Inflammation Activation and Resolution by Controlling AMPK Activities

    H. Wang,1,2 M. Ni,1,2 H. Zhou,2 L. Lu,2 R. Busuttil,1 J. Kupiec-Weglinski,1 Y. Zhai.1

    1Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; 2Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

    Background & Aims: Glycogen synthase kinase 3β (Gsk3β) is ubiquitously expressed with distinctive functions in different types of cells. Although its roles in regulating innate…
  • 2018 American Transplant Congress

    Is Percent Exception at Transplant a Driver of MELD Inflation?

    D. Schladt,1 J. Snyder,1 A. Israni,1 W. Kim,2 J. Lake.3

    1SRTR, Minneapolis, MN; 2Stanford University, Stanford, CA; 3Univ of Minnesota, Minneapolis, MN.

    Before 2016, the proportion of deceased donor liver recipients with an exception status at liver transplant (LT) correlated strongly with median MELD at transplant (MMaT)…
  • 2018 American Transplant Congress

    Factors Associated with Listing for Liver Transplantation in an OPO Other Than the Resident OPO

    S. Zhou, A. Massie, S. Gentry, D. Segev.

    The JHU, Baltimore.

    Geographic disparity in access to liver transplantation has been well described. Candidates may travel to be listed in OPOs with better access. We hypothesized that…
  • 2018 American Transplant Congress

    PGE2/Beta-Catenin/XBP1 Signaling Controls Mesenchymal Stem Cell-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury

    C. Li, S. Yue, L. Jiang, Q. Zhu, D. Farmer, R. Busuttil, J. Kupiec-Weglinski, B. Ke.

    The Dumont-UCLA Transplant Center, Department of Surgery, Los Angeles, CA.

    Background: Mesenchymal stem cells (MSCs) display profound immunomodulatory properties and tissue repairing capability under inflammatory conditions. However, it is unknown how MSCs may affect immunity…
  • 2018 American Transplant Congress

    Impact of On-Site Overestimation of Macrosteatosis on Donor Liver Biopsy

    M. Wright, J. Seal, L. De Gregorio, H. Bohorquez, D. Bruce, E. Bugeaud, I. Carmody, A. Mathur, D. Sonnier, G. Galliano, I. Oliva, L. Bratton, G. Loss.

    Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans.

    Introduction: Estimation of hepatic steatosis is an important variable in determining suitability of a donor liver allograft for transplantation. Differentiation between and quantification of macro-…
  • 2018 American Transplant Congress

    Comprehensive Validation of Different Clinical Prediction Models on Short- and Long-Term Outcome Following Orthotopic Liver Transplantation

    J. Boecker,1 Z. Czigany,1 J. Bednarsch,1 I. Amygdalos,1 F. Meister,1 D. Morales Santana,1 W. Schoening,1 T. Ulmer,1 M. Krebbers,1 G. Koek,1 D. Kroy,2 F. Tacke,2 C. Trautwein,2 U. Neumann,1 G. Lurje.1

    1Department of Surgery and Transplantation, University Hospital RWTH, Aachen, Germany; 2Department of Internal Medicine III, University Hospital RWTH, Aachen, Germany.

    Background: Organ shortage remains a major problem in orthotopic liver transplantation (OLT). An optimal utilization of the donor pool with better prediction of outcome is…
  • 2018 American Transplant Congress

    Curative Correction of FAH Deficiency by Chimeric Stem Cells Transplantation

    D. Joo,1,2 E. Nelson,1 Y. Zhang,1 B. Amiot,1 S. Ho,3 C. Lancto,4 D. Carlson,4 L. Queiroz,5 S. Nyberg.1

    1Division of Transplant Surgery, Mayo Clinic, Rochester, MN; 2Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; 3Department of Pathology, University of Michigan, Ann Arbor, MI; 4Recombinetics Inc, Saint Paul, MN; 5International Center for Biotechnology, Cooperative Resources International, Mount Horeb, WI.

    Fumarylacetoacetate hydrolase (FAH) deficient pigs have been proposed as surrogate hosts for large scale in vivo expansion of normal FAH+ hepatocytes. However, immunologic rejection prevents…
  • 2018 American Transplant Congress

    DSA-Level Liver Availability and Liver Utilization

    S. Zhou, M. Bowring, A. Massie, S. Gentry, D. Segev.

    The JHU, Baltimore.

    DSA-level geographic disparity in access to deceased-donor liver transplantation is well described. However, understanding the relationship between liver availability in a DSA and exportation of…
  • 2018 American Transplant Congress

    Poverty, End Stage Liver Disease, and Transplantation in Georgia

    R. Lynch,1 K. Ross,1 J. Magliocca,1 D. Goldberg,2 R. Patzer.1

    1Surgery, Emory University, Atlanta, GA; 2Medicine, University of Pennsylvania, Philadelphia, GA.

    Background: Though discussions of equity in liver transplantation remain focused primarily on relative availability of allografts as a measure of access, differences in disease burden…
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