2019 American Transplant Congress
Pluripotent Stem Cell Differentiation: Delaying Forward Differentiation Signals Maintains Definitive Endoderm Phenotype for Cellular Transplantation
*Purpose: Endodermal precursors (EP), derived in vitro from mouse pluripotent stem cell (PSC) sources, are capable of clinically useful engraftment in the unmodified (quiescent) liver…2019 American Transplant Congress
DOME: A New Strategy for Prioritizing Hepatocellular Carcinoma Patients on the Liver Transplant Waitlist
*Purpose: Currently, adult HCC patients are prioritized for liver transplantation by receiving MELD exception points, determined primarily by time on waitlist without regard to actual…2019 American Transplant Congress
Utilizing Imagestream Technology to Determine Hepatocellular CD38 Localization
Department of Cardiac Surgery, The Ohio State Univ. Medical Center, Columbus, OH
*Purpose: CD38 is an ecto-enzyme that modulates intracellular calcium levels by producing potent secondary messengers, which utilize the cellular NAD pool and lead to increased…2019 American Transplant Congress
Impact of Donor Abdominal Aortic Calcification on Bile Duct Complications of Recipients after Living Donor Liver Transplantation; a Retrospective Study
Hiroshima University Hospital, Hiroshima, Japan
*Purpose: Abdominal aortic calcification (AAC) is known as a risk factor of cardiovascular diseases and renal dysfunction. We have reported that the significance of the…2019 American Transplant Congress
Natural Course Of Tacrolimus Intra-patient Variability In Liver Transplant Recipients
University of Cincinnati, Cincinnati, OH
*Purpose: The evolution of tacrolimus (TAC) intra-patient variability (IPV) post liver transplant (LT) remains to be characterized. Identification of factors associated with high TAC-IPV may…2019 American Transplant Congress
Sustained Biologic Response To Neoadjuvant Therapy Predicts Excellent Liver Transplant Outcomes For Locally Advanced Intrahepatic Cholangiocarcinoma
*Purpose: Intrahepatic cholangiocarcinoma (iCCA) is a contraindication for liver transplant (LT), but prior studies limited evaluation to incidental iCCA. We recently reported significant improvement in…2019 American Transplant Congress
Liver Transplantation for Acute Liver Failure: A 16 Year Experience with 214 Patients in the Post-MELD Era
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Liver transplantation (LT) remains the gold standard treatment for acute liver failure (ALF). Our center has previously reported outcomes in the pre-Model for End…2019 American Transplant Congress
mTOR Inhibitors Enhance Antitumor Activity of Liver Resident NK Cells
Gastroenterology and transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…2019 American Transplant Congress
Immunologic Outcomes In Recipients Of Orthotopic Liver Transplant Induced Only With Steroids
The University of Texas Medical Branch, Galveston, TX
*Purpose: Liver allografts are resistant to antibody mediated rejection (AMR) in the presence of preformed alloantibodies. In most cases donor specific antibodies (DSAs) disappear a…2019 American Transplant Congress
Spindle and Kinetochore Associated Complex Subunit 3 Promotes Tumor Growth by Regulating CDK2/p53 Phosphorylation in Hepatocellular Carcinoma
*Purpose: Spindle and kinetochore-related complex subunit 3 (SKA3) is a part of the spindle and kinetochore-related complexes, which are crucial for the proper timing of…
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