Articles tagged "Liver"

2019 American Transplant Congress
Spindle and Kinetochore Associated Complex Subunit 3 Promotes Tumor Growth by Regulating CDK2/p53 Phosphorylation in Hepatocellular Carcinoma
Y. Hou¹, Z. Wang², L. Wu³
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ²The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ³Organ transplant center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: Spindle and kinetochore-related complex subunit 3 (SKA3) is a part of the spindle and kinetochore-related complexes, which are crucial for the proper timing of…
2019 American Transplant Congress
Evaluation of Liver Transplantation among Advanced Age Recipients in a Large Multicenter U.S. Cohort
A. Goel¹, A. Kwong², D. Devuni³, C. Wang², J. Boike⁴, J. Jo⁴, L. VanWagner⁴, M. Serper⁵, L. Jones⁵, R. Sharma⁶, E. Verna⁶, J. Shor³, M. German⁷, A. Hristov⁷, A. Lee⁷, E. Spengler⁷, A. Koteish⁸, G. Sehmbey⁹, A. Seetharam⁹, N. John¹, Y. Patel¹⁰, M. Kappus¹⁰, T. Couri¹¹, R. Salgia¹², Q. Nhu¹³, C. Frenette¹³, J. Lai²
¹Stanford University, Palo Alto, CA, ²University of California, San Francisco, CA, ³University of Massachusetts, Worcester, MA, ⁴Northwestern, Chicago, IL, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Columbia University, New York, NY, ⁷University of Wisconsin, Madison, WI, ⁸Florida Hospital, Orlando, FL, ⁹University of Arizona, Phoenix, AZ, ¹⁰Duke University, Durham, NC, ¹¹University of Chicago, Chicago, IL, ¹²Henry Ford Hospital, Detroid, MI, ¹³Scripps, San Diego, CA
*Purpose: The proportion of adults ≥70 years (y) listed for liver transplant (LT) in the U.S. is rising. Outcomes in this growing population are limited…
2019 American Transplant Congress
Interferon Sensitivity Promotes Recovery from Acetaminophen Induced Liver Injury
S. Datta, T. Hamilton, G. C. Sen
Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: The current study was undertaken to assess the role of inflammatory signaling during induction of and recovery from acetaminophen induced acute liver failure.*Methods: C57BL/6…
2019 American Transplant Congress
Access to Deceased Donor Liver Transplant for Candidates in Hawaii and Puerto Rico
A. M. Robinson¹, I. K. Kim², A. K. Mathur³, S. E. Rosas⁴
¹United Network for Organ Sharing, Richmond, VA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³Mayo Clinic Arizona, Phoenix, AZ, ⁴Joslin Diabetes Center, Harvard Medical School, Boston, MA
*Purpose: Hawaii and Puerto Rico comprise their own donor service areas (DSAs), HIOP and PRLL respectively. The liver programs in these locations serve populations mostly…
2019 American Transplant Congress
Glycogen Synthase Kinase 3alpha Serine 21 Phosphorylation Inhibits Hepatocyte Autophagy to Facilitate Liver Ischemia Reperfusion Injury
M. Ni¹, H. Zhou², R. Busuttil¹, J. Kupiec-Weglinski¹, X. Wang², Y. Zhai¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Glycogen synthase kinase 3 (Gsk3) has α and β isoforms. They are constitutively active in cells and inhibited upon stimulations by N-terminal serine phosphorylation.…
2019 American Transplant Congress
Candida auris after Liver Transplant
N. M. Theodoropoulos, R. Ellison, J. S. Daly, A. Bozorgzadeh, D. A. Mack, L. Gibson, S. M. Levitz
University of Massachusetts Medical School, Worcester, MA
*Purpose: C. auris is a difficult to eradicate yeast that has caused outbreaks in hospitals in recent years. We report a cluster of liver transplant…
2019 American Transplant Congress
Scaffold-Free 3D-Bioprinting of Human Extrahepatic Bile Duct
K. Saglam¹, W. Zhang¹, L. J. Smith², A. Isidan¹, A. M. Chen¹, R. A. Naqvi¹, E. Gramelspacher¹, P. Li¹, B. Ekser¹
¹Transplant Division, Department of Surgery, Indiana University, Indianapolis, IN, ²3D-Bioprinting Core, Indiana University School of Medicine, Indianapolis, IN
*Purpose: Biliary complications are common especially in living and also in deceased donor liver transplantation (LT). Presence of multiple orifices in biliary anastomosis and ischemia,…
2019 American Transplant Congress
National Landscape of Donors Allocated through the Hope Act in the United States
A. R. Wilk¹, R. Hunter², M. A. McBride², D. K. Klassen²
¹Research, United Network for Organ Sharing, Richmond, VA, ²United Network for Organ Sharing, Richmond, VA
*Purpose: To address the shortage of donor organs and to increase transplantation opportunities for HIV+ recipients, the HIV Organ Policy Equity (HOPE) Act was enacted…
2019 American Transplant Congress
Simulated Tier Variability
N. Salkowski, A. Wey, J. Snyder
SRTR, Minneapolis, MN
*Purpose: The Scientific Registry of Transplant Recipients semi-annually assigns transplant programs to one of five performance tiers for 1-year graft survival in its program-specific reports…
2019 American Transplant Congress
Comparison of Proton Pump Inhibitors versus Histamine-2-Receptor Antagonists on Clostridium difficile Rates in Liver Transplant Recipients
S. Wiehe, K. Roach, A. Qamar
Lahey Hospital and Medical Center, Burlington, MA
*Purpose: To determine if there is a difference in 90 day Clostridium difficile infection (CDI) rates before and after the stress ulcer prophylaxis (SUP) protocol…