Articles tagged "Liver"

2019 American Transplant Congress
Ex-vivo Xenoperfusion Of Wild Type And Galtko.hcd55 Pig Livers With Human Whole Blood
D. Detelich, C. Rickert, C. Eymard, C. Carroll, S. Kimura, H. Yeh, J. Markmann
Massachusetts General Hospital, Boston, MA
*Purpose: Pig-to-human liver xenotransplantation is not currently feasible due to rapid and profound thrombocytopenia, coagulopathy and hyperacute rejection. Successful development of genetically modified swine to…
2019 American Transplant Congress
Inflammation and Fibrosis Are Observed in 34% of Clinically Stable Adult Liver Transplant Recipients
L. Sun¹, J. Levitsky², S. Feng³, A. Humar⁴, A. J. Demetris⁴, J. Emond⁵, A. Shaked⁶, G. Klintmalm⁷, K. Mason⁸, M. DesMarais¹, A. Priore⁹, N. Bridges⁹, B. E. Burrell¹⁰, S. Chandran³, J. Markmann¹¹
¹ITN, San Francisco, CA, ²Northwestern, Chicago, IL, ³UCSF, San Francisco, CA, ⁴UPMC, Pittsburg, PA, ⁵Columbia, New York, NY, ⁶UPenn, Philadelphia, PA, ⁷Baylor, Dallas, TX, ⁸Rho, Chapel Hill, NC, ⁹NIAID, Bethesda, MD, ¹⁰ITN, Bethesda, MD, ¹¹MGH, Boston, MA
*Purpose: OPTIMAL is a 7-center immunosuppression withdrawal (ISW) study in non-autoimmune, non-HCV adult liver transplant recipients ≥3 yrs post-transplant (tx) (NCT02533180). Subjects underwent a screening…
2019 American Transplant Congress
Ready for Prime Time: Intentional Allocation of Hepatitis C Positive Livers into Hepatitis C Negative Recipients
P. N. Martins¹, B. Movahedi¹, D. Devuni², P. Mahboub¹, A. Bozorgzadeh¹
¹Surgery, Division of Transplantation, University of Massachusets, Worcester, MA, ²Medicine, Division of Hepatology, University of Massachusets, Worcester, MA
*Purpose: The current discrepancy between supply and demand of liver grafts has dramatically increased the waiting time and mortality on the waiting list. The recent…
2019 American Transplant Congress
Kupffer Cells Are Critical for Inflammation Resolution in Liver Ischemia Reperfusion Injury via TIM-4 Mediated Efferocytosis
M. Ni¹, H. Wang¹, D. Jin¹, J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, X. Wang², Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a clinical problem associated with both surgical and non-surgical settings. Innate immune-dominated inflammation drives the pathogenesis of liver…
2019 American Transplant Congress
Perioperative Lactate Levels Are Sensitive Marker to Predict Early Allograft Dysfunction and Short-Term Graft Failure after Liver Transplant
K. Takahashi¹, S. Nagai², K. Collins², M. Rizzari², M. Safwan², S. Jafri³, T. Oda¹, A. Yoshida², M. Abouljoud²
¹Surgery, University of Tsukuba, Tsukuba, Japan, ²Surgery, Henry Ford Hospital, Detroit, MI, ³Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: Lactate is one of the most frequently used makers to understand real-time graft function after liver transplant (LT). This study aimed to investigate risk…
2019 American Transplant Congress
Tumor Necrosis as a Result to Pre-Transplant Bridging Treatment for Hepatocellular Carcinoma and Its Effect on Post-Transplant Outcome
S. Radunz¹, A. Kirschner¹, J. M. Theysohn², C. Schotten³, T. Benkö¹
¹General, Visceral and Transplant Surgery, University Hospital Essen, Essen, Germany, ²Diagnostic and Interventional Radiology and Neurradiology, University Hospital Essen, Essen, Germany, ³Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
*Purpose: As a bridge to liver transplantation, locoregional treatments are commonly employed in hepatocellular carcinoma (HCC) patients to prevent tumor progression during waiting time. Objective…
2019 American Transplant Congress
Restrictive Medicaid Policies Reduce Access to Liver Transplant for Alcohol-Associated Liver Disease
B. P. Lee, V. Eric, P. Mark, J. Dodge, N. Terrault
UCSF, SF, CA
*Purpose: Medicaid policies requiring specific documentation of abstinence (e.g. 6 months) and/or rehabilitation for financial coverage of liver transplant (LT) for alcohol-associated liver disease (ALD)…
2019 American Transplant Congress
Continuous Distribution: LSAM Simulation Study
T. Weaver¹, N. Salkowski¹, J. Snyder¹, D. Schladt¹, J. Pyke¹, A. Herreid¹, B. Thompson¹, W. Kim², J. Lake³, A. Israni¹
¹SRTR, Minneapolis, MN, ²Stanford Univ, Stanford, CA, ³Univ of Minnesota, Minneapolis, MN
*Purpose: This liver simulated allocation model (LSAM) study of a simple continuous distribution system for several parameter values introduces and describes its characteristics, demonstrating how…
2019 American Transplant Congress
Human Leukocyte Antigen Class I (HLA-I) Antibodies in Patients Undergoing Liver Transplantation: Implications for Platelet Transfusion Support
M. Wong¹, R. Narra², M. Selim¹, M. A. Zimmerman¹, A. Padmanabhan³, J. C. Hong¹
¹Div. of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI, ²Div. of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, ³Medical College of Wisconsin and BloodCenter of Wisconsin, Milwaukee, WI
*Purpose: Liver transplantation is a high platelet transfusion (PLT) setting due to the elevated incidence of thrombocytopenia and bleeding. HLA-I antibodies are thought to have…
2019 American Transplant Congress
Inferior Graft and Patient Survival Following Offspring to Parent Living Donor Liver Transplantation
R. A. Choudhury, A. Dagan, H. Yaffe, D. Yoeli, E. A. Pomfret, T. L. Nydam
Transplant Surgery, University of Colorado, Aurora, CO
*Purpose: Offspring (donor) to parent (recipient) transplant is the most common form of living donor liver transplant in the United States. Following living donor kidney…