2022 American Transplant Congress
DCD Liver Grafts Can Safely be Used for Recipients with Grade 1-2 Portal Vein Thrombosis
*Purpose: Limited data is available in the literature regarding patients with portal vein thrombosis (PVT) receiving a liver transplant (LT) from a donation after circulatory…2022 American Transplant Congress
Unique Treatment of Duodenal Perforation in Middle Aged Female Patient with Liver Transplant
1Wayne State University School of Medicine, Detroit, MI, 2Henry Ford Health System, Detroit, MI
*Purpose: We describe a unique method of treatment of duodenal perforation due to biliary stent using an over the scope clip-OTSC.*Methods: A 68 year old…2022 American Transplant Congress
National Attitudes Towards Early Liver Transplantation for Alcoholic Liver Disease
*Purpose: Pre-transplant abstinence requirements, notably the 6-month sobriety guideline, limit access to liver transplant for patients with severe alcoholic hepatitis (SAH). This study examines the…2022 American Transplant Congress
Phase I/ii Car-Treg Cell Therapy Clinical Trial To Induce Long-term Tolerance In Liver Transplant Patients
1King's College London, London, United Kingdom, 2Quell Therapeutics Ltd, London, United Kingdom
*Purpose: Life-long pharmacological immunosuppression (IS) is considered essential to prevent rejection following liver transplantation (LT), but is associated with significant side effects such as infections,…2022 American Transplant Congress
Experience Using Intra-Operative Dialysis in Surgically Complex Liver Transplantation
1Anesthesiology, Ochsner, New Orleans, LA, 2Surgery, Ochsner, New Orleans, LA
*Purpose: At our high-volume center, we often perform liver transplantation (LT) on surgically complex patients that includes re-transplantation, prior open liver resection, bariatric surgeries, extensive…2022 American Transplant Congress
A Intention-to-Treat Analysis of 881 Consecutively Waitlisted Patients to Develop a Survival Benefit Model for Hepatocellular Carcinoma Liver Transplant Candidates
*Purpose: The current liver transplantation (LT) selection paradigm for hepatocellular carcinoma (HCC) patients ignores the variable risks of waitlist dropout and post-LT recurrence/death, with the…2022 American Transplant Congress
Telemedicine Implementation in Solid Organ Transplant (SOT) Clinics is Associated with Satisfaction Among Patients and Providers but Increased Burden on Staff
University of California, San Francisco, San Francisco, CA
*Purpose: Telemedicine is an essential part of healthcare delivery and has grown exponentially during the COVID-19 pandemic. Data on optimal utilization and implementation of telemedicine…2022 American Transplant Congress
Ikaros-SIRT1 Signaling Axis Regulates Macrophage Pyroptosis and Ischemia-Reperfusion Injury (IRI) in Mouse and Human Liver Transplantation
1UCLA Medical Center, Los Angeles, CA, 2NIEHS, Durham, NC
*Purpose: Although Ikaros is a well-established regulator of lymphopoiesis, its role in myeloid cells and organ IRI remains unclear. We recently reported that the SIRT1-mediated…2022 American Transplant Congress
Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses Than Alternative Alloantigen-Specific Treg Strategies
1King's College London, London, United Kingdom, 2Quell Therapeutics, London, United Kingdom
*Purpose: Conferring alloantigen-specificity to ex vivo expanded CD4+CD25+Foxp3+ Tregs increases their capacity to counteract effector alloimmune responses following adoptive transfer into transplant recipients. This has…2022 American Transplant Congress
The Limited Role of Liver Transplantation in Porto-Pulmonary Hypertension Pathology
*Purpose: Portopulmonary hypertension (POPH) refers to pulmonary artery hypertension (PH) as a consequence of portal hypertension with or without liver disease. Previous studies used pulmonary…
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