ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver transplantation"

  • 2015 American Transplant Congress

    Pre-Transplant Portal Vein Recanalization-Transjugular Intrahepatic Portosystemic Shunt in Patients With Chronic Portal Vein Thrombosis

    B. Thornburg, K. Desai, T. Baker, J. Fryer, M. Abecassis, J. Caicedo, L. Kulik, R. Salem.

    Northwestern Memorial Hospital, Chicago, IL.

    Background: Chronic, occlusive portal vein thrombosis (PVT) associated with cirrhosis represents a relative contraindication to liver transplantation (LT) in some centers. From a surgical perspective,…
  • 2015 American Transplant Congress

    Incidence and Impact of De Novo Donor-Specific Anti-HLA Antibodies in ABO-Compatible Liver-Transplant Recipients

    A. Del Bello,1,2 N. Congy-Jolivet,2,3,4 D. Milongo,1 C. Guilbeau-Frugier,2,5 L. Lavayssière,1 F. Muscari,2,6 L. Rostaing,1,2,7 N. Kamar.1,2,7

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Université Paul Sabatier, Faculté de Médecine, Toulouse, France; 3Molecular Immunogenetics Laboratory, EA 3034, Faculté de Médecine Purpan, IFR150, Toulouse, France; 4Department of Immunology, CHU Rangueil, Toulouse, France; 5Department of Pathology, CHU Rangueil, Toulouse, France; 6Surgery and Liver Transplantation, CHU Rangueil, Toulouse, France; 7INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France.

    Background: The incidence and consequences of de novo donor-specific anti-HLA antibodies (DSAs) after liver transplantation (LT) are not well known. Thus, we investigated the incidence,…
  • 2015 American Transplant Congress

    HO-1 Modified Macrophages Promote Autophagy by Activating Sirt1/TGF-β/Smad4 Signaling in Ischemia-Stressed Mouse Liver Transplants

    S. Yue, J. Huang, K. Nakamura, M. Zhou, X.-D. Shen, R. Busuttil, B. Ke, J. Kupiec-Weglinski.

    Dumont-UCLA Transplant Ctr, Dept. of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.

    Background: Although heme oxygenase-1 (HO-1) is known to induce alternative macrophage activation towards an anti-inflammatory M2 phenotype, the underlying mechanisms remain elusive. Autophagy may play…
  • 2015 American Transplant Congress

    Biliary Complication After Living Donor Liver Transplantation According to Biliary Reconstruction Methods

    J. Lee,1,2 J. Lee,1,2 D. Han,1,2 J. Lee,3 M. Ju,1,2 M. Kim,1,2 G. Choi,1,2 J. Choi,1,2 S. Kim,1,2 D. Joo.1,2

    1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; 3Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea.

    BackgroundDespite improvement of operative techniques and long term outcomes, biliary complication remains as a severe obstacle in living donor liver transplantation.MethodsMedical records of 245 adult…
  • 2015 American Transplant Congress

    Racial Disparities in Living Donor Liver Transplantation

    Y. Nobel,1 K. Forde,2 L. Wood,3 P. Yoo,4 P. Abt,3 D. Goldberg.2

    1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 2Department of Medicine, University of Pennsylvania, Philadelphia, PA; 3Division of Transplant Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA; 4Department of Surgery, Yale University School of Medicine, New Haven, CT.

    Purpose: Living donor liver transplantation (LDLT) is an alternative to deceased donor transplantation (DDLT), and can mitigate the risk of dying while waiting for transplant.…
  • 2015 American Transplant Congress

    Preventing Cytomegalovirus Infection in Intermediate-High Risk Liver Transplant Recipients: Acyclovir Vs Valganciclovir

    S. Dulanya, A. Anamisis, D. Tsapepas.

    Department of Pharmacy, New York Presbyterian Hospital, New York City, NY.

    Cytomegalovirus (CMV) is an opportunistic infection responsible for profound morbidity and mortality among solid organ transplant recipients. A donor and recipient's CMV IgG serostatus influences…
  • 2015 American Transplant Congress

    An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation

    C. Falk,1 I. Goldschmidt,2 F. Mutschler,2 C. Neudörfl,1 J. Keil,1 K. Daemen,1 F. Lehner,3 R. Mikolajzcyk,4 A. Karch,4 U. Baumann.2

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Division of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany; 3Department of Visceral General and Transplant Surgery, Hannover Medical School, Hannover, Germany; 4Department of Epidemiology, Helmholtz Center for Infection Research, HZI, Braunschweig, Braunschweig, Germany.

    The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…
  • 2015 American Transplant Congress

    Long-Term Outcome After Liver Transplantation for Unresectable Hepatocellular Carcinoma Following Yttrium-90 Radioembolization Bridging Treatment

    S. Radunz,1 T. Benkoe,1 J. Best,2 A. Bockisch,3 T. Lauenstein,4 H. Baba,5 A. Paul,1 J. Treckmann.1

    1General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; 2Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany; 3Nuclear Medicine, University Hospital Essen, Essen, Germany; 4Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany; 5Pathology and Neuropathology, University Hospital Essen, Essen, Germany.

    Background: Liver transplantation remains the only curative treatment option for patients with unresectable hepatocellular carcinoma (HCC). Several bridging treatments are employed because the limited availability…
  • 2015 American Transplant Congress

    National Transplantation Pregnancy Registry: Cholestasis of Pregnancy in Liver Transplant Recipients

    M. Moritz,1,2 L. Coscia,2 S. Constantinescu,3 D. Armenti.2

    1Lehigh Valley Health Network, Allentown; 2National Transplantation Pregnancy Registry, Gift of Life Institute, Philadelphia; 3Temple University School of Medicine, Philadelphia.

    Cholestasis of pregnancy (COP) occurs in approximately 1% of pregnancies and is associated with increased risk of premature delivery. The purpose of this study was…
  • 2015 American Transplant Congress

    Identifying the “Operational Tolerant” Pediatric Liver Transplant Recipient by Cytometry by Time-of-Flight

    A. Lau,1,2 M. Vitalone,1 K. Haas,3 T. Shawler,1 C. Esquivel,1 O. Martinez,1 R. Castillo,3 S. Krams.1

    1Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; 2Pediatrics, Div. Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco, San Francisco, CA; 3Pediatrics, Div. Gastroenterology, Hepatology, and Nutrition, Stanford University, Stanford, CA.

    Liver allografts are known to be well tolerated and indeed, some recipients of liver allografts retain stable graft function in the absence of immunosuppression. The…
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