Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Living donor liver transplantation (LDLT) has developed as an alternative to decease donor liver transplantation (DDLT) to overcome the critical shortage of deceased organ donations. However, the evidence supporting a LDLT for high model for end stage liver disease (MELD) score recipient is weak. We compared the outcomes of LDLT and DDLT according to MELD scores.
The study included 425 adult patients who underwent liver transplantation between 2006 and 2013 at Severance Hospital (268 LDLT, 157 DDLT). Patients with re-transplantation and fulminant liver failure were excluded from the study. Recipients were categorized according to their MELD score into low (MELD score ≤25) and high (MELD score >25) MELD group.
Recipient characteristics were similar between LDLT and DDLT, with the exception of higher MELD score in DDLT group (19.85 vs. 13.52, p<0.001). The DDLT donors were significantly older than LDLT donors (42.55 vs. 31.48, p<0.001). Hepatocellular carcinomas were present in 57.4% of the recipients (60.8% in LDLT vs. 51.6% in DDLT, p=0.063). The median follow-up was 32 months (range, 0 to 105 months). LDLT demonstrated significantly better patient survival than DDLT in low MELD group (86.9% vs. 74.8% at 5 years, p=0.006). Survival after LDLT was not inferior to DDLT in high MELD group (72.1% vs. 57.3% at 5 years, p=0.265).
Patient survival by time since LDLT or DDLT for (A) patients with a MELD score ≤ 25 and (B) patients with a MELD score > 25
LDLT=living donor liver transplantation, DDLT=deceased donor liver transplantation, MELD=model for end stage liver disease
LDLT provided similar survival to DDLT in high MELD score recipients. Thus, when deceased donor organs are scare, a high MELD score should not be a contraindication to LDLT.
To cite this abstract in AMA style:Lee J, Lee J, Joo D, Han D, Ju M, Choi J, Kim S, Kim M. Outcomes of Living and Deceased Donor Liver Transplant Recipients According to the MELD Score [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/outcomes-of-living-and-deceased-donor-liver-transplant-recipients-according-to-the-meld-score/. Accessed April 8, 2020.
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