Articles tagged "Liver transplantation"

2015 American Transplant Congress
Regional Variations: Liver Transplant Tourism Within the US
C. Frenette,¹ A. Harper,² R. Schaffer,¹ J. Fisher,¹ A. Baquerizo,¹ C. Marsh.¹
¹Department of Organ Transplantation, Scripps Clinic/Green Hospital, La Jolla, CA; ²United Network for Organ Sharing, Richmond, VA.
Aim: Given the current geographic disparities in average MELD scores at liver transplantation (OLT), there is increasing interest in patients who travel for OLT and…
2015 American Transplant Congress
End of Treatment Liver Biopsy With Sofosbuvir: Histologic Changes Suggestive of Hepatitis C Activity in Liver Transplant Recipients With Achieved SVR
B. Ismail,¹ X. Zervos,¹ P. Bejarano,² M. Waton,¹ D. Beltran,³ D. Sears,¹ A. Tzakis.¹
¹Liver Transplant, Cleveland Clinic Florida, Weston, FL; ²Pathology, Cleveland Clinic Florida, Weston, FL; ³Pharmacy, Cleveland Clinic Florida, Weston, FL.
Background: Interferon (IFN) free HCV regimens are associated with better tolerability and efficacy. The majority of studies report biochemical and virological response; however limited information…
2015 American Transplant Congress
Improved Renal Function Post-Liver Transplant With Earlier Everolimus Conversion
S. Lin,¹ M. Zimmerman,² V. Lewis,¹ S. Biggins,³ C. Ruller,⁴ I. Kam,⁴ T. Nydam.⁴
¹Pharmacy Dept, University of Colorado Hospital, Aurora; ²Division of Transplant Surgery, Medical College of Wisconsin, Wisconsin; ³Division of Gastroenterology/Hepatology, University of Colorado, Aurora; ⁴Division of Transplant Surgery, University of Colorado, Aurora.
Calcineurin inhibitors (CNI) play an important role in preventing acute rejection (AR) post-liver transplant. Its long-term use is limited by development of nephrotoxicity. Optimal timing…
2015 American Transplant Congress
Comparison of Renal Outcomes for Liver Transplant Recipients With Pretransplant Renal Dysfunction Receiving Sirolimus Or Tacrolimus With Rabbit Antithymocyte Globulin Induction
B. Duhart,¹ W. Ally,² V. Rao,³ A. Krauss,⁴ J. Eason,³ J. Vanatta.³
¹University of Tennessee College of Pharmacy, Memphis, TN; ²Pharmacy, University of Virginia Medical Center, Charlottesville, VA; ³Surgery, Methodist University Hospital Transplant Institute/University of Tennessee Health Science Center, Memphis, TN; ⁴Pharmacy, Methodist University Hospital, Memphis, TN.
Published data are limited describing renal outcomes in orthotopic liver transplant (OLT) recipients prescribed de novo sirolimus (SRL) maintenance immunosuppression and rabbit antithymocyte globulin (rATG).…
2015 American Transplant Congress
HLA Matching Affects Patient Survival, Graft Survival, and Incidence of Rejection Episodes in Largest Analysis to Date
J. Weiner, Z. Cui, S. Mohan, E. Verna, A. Griesemer, J. Emond.
Columbia Center for Liver Disease and Transplantation, New York Presbyterian-Columbia University Medical Center, New York, NY.
Introduction: Though human leukocyte antigen (HLA) matching between donor and recipient affects both graft and patient survival after kidney and heart transplantation, prior analysis has…
2015 American Transplant Congress
Impact of Donor Post-Extubation O2 Delivery on Recipient Hypoxic Cholangiopathy in Donation After Circulatory Death Liver Transplantation: The University of Colorado Experience
T. Chirichella,¹ C. Dunham,² M. Zimmerman,⁴ K. Conzen,¹ S. Kelley,³ E. Phelan,¹ T. Steinberg,¹ T. Nydam,¹ T. Bak,¹ I. Kam,¹ M. Wachs.¹
¹Transplant Surgery, University of Colorado Hospital, Aurora, CO; ²Department of Surgery, St. Elizabeth Health Center, Youngstown, OH; ³Donor Alliance Organ Procurement Organization, Denver, CO; ⁴Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI.
The critical shortage of deceased organ donors has led to increased utilization of DCD liver grafts. The purpose of this study was to evaluate DCD…
2015 American Transplant Congress
Ischemia Reperfusion Injury in Orthotopic Liver Transplantation Primes the Adaptive Immune Response and Generation of Proinflammatory Cytokines
A. Zarrinpar,¹ P. Rao,² C. Lassman,² V. Agopian,¹ F. Kaldas,¹ D. Farmer,¹ R. Busuttil,¹ Y. Zhai,¹ J. Kupiec-Weglinski,¹ E. Reed.²
¹Surgery, University of California, Los Angeles, Los Angeles, CA; ²Pathology and Lab Medicine, University of California, Los Angeles, Los Angeles, CA.
Background: Transplanted organs are exquisitely susceptible to effects of ischemia/reperfusion injury (IRI), an immune-mediated process that occurs during transplantation and beyond. Recipient and graft outcomes,…
2015 American Transplant Congress
Long-Term Survival Outcomes of Liver Transplantation for Klatskin Tumour: A Comparative Study With Radical Resection Surgery
A. Hu, X. Zhu, X. He.
Department of general Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background and aim: Besides radical resection (RR), Liver transplantation (LT) is another suggested surgical modality for hilar cholangiocarcinoma (Klatskin tumour, KT) especially for patients whose…
2015 American Transplant Congress
Estimation of Glomerular Filtration Rate With Serum Cystatin C Accurately Discriminates Renal Dysfunction in Liver Transplant Candidates With End-Stage Liver Disease
S. Gonzalez,¹ J. Trotter,¹ H. Szerlip,² M. Levy,³ A. Chandrakantan,⁴ A. Yango,⁴ A. Rajagopal,⁴ Y. Barri,⁴ K. Rice,⁴ M. Saim,² L. Melton,⁴ M. Emmett,² G. Klintmalm,³ B. Fischbach.⁴
¹Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; ²Nephrology, Baylor University Medical Center, Dallas, TX; ³Transplant Surgery, Baylor Simmons Transplant Institute, Fort Worth, TX; ⁴Nephrology, Baylor Simmons Transplant Institute, Fort Worth, TX.
Background: Renal insufficiency is common in end-stage liver disease (ESLD) and is linked to survival in patients awaiting liver transplantation. Serum creatinine correlates poorly with…
2015 American Transplant Congress
Safety and Efficacy of All Oral DAA Therapy for Genotype 1 HCV Post-Liver Transplant: Interval Results from the HCV-TARGET Multicenter Prospective Observational Study
J. O'Leary,¹ R. Brown,² K. Reddy,³ A. Kuo,⁴ G. Morelli,⁵ R. Stravitz,⁶ G. Everson,⁷ C. Durand,⁸ H. Vargas,⁹ P. Kwo,¹⁰ C. Frenette,¹¹ J. Peter,¹² M. Vainorius,¹² L. Akushevich,¹² D. Nelson,⁵ M. Fried,¹² N. Terrault.¹³
¹Baylor University Medical Center, TX; ²Columbia University, NY; ³University of Pennsylvania, PA; ⁴UCSD, CA; ⁵University of Florida, Gainesville, Gainesville, FL; ⁶Virginia Commonwealth University, VA; ⁷University of Colorado, CO; ⁸Johns Hopkins, MD; ⁹Mayo Clinic, AZ; ¹⁰Indiana University, IL; ¹¹Scipps Clinic, CA; ¹²University of North Carolina, NC; ¹³UCSF, CA.
The safety and efficacy of direct-acting antivirals (DAA) for HCV post-LT remain unknown. METHODS: We describe the safety and efficacy of all oral DAA-therapy for…