ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Estimation of Glomerular Filtration Rate With Serum Cystatin C Accurately Discriminates Renal Dysfunction in Liver Transplant Candidates With End-Stage Liver Disease

S. Gonzalez,1 J. Trotter,1 H. Szerlip,2 M. Levy,3 A. Chandrakantan,4 A. Yango,4 A. Rajagopal,4 Y. Barri,4 K. Rice,4 M. Saim,2 L. Melton,4 M. Emmett,2 G. Klintmalm,3 B. Fischbach.4

1Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX
2Nephrology, Baylor University Medical Center, Dallas, TX
3Transplant Surgery, Baylor Simmons Transplant Institute, Fort Worth, TX
4Nephrology, Baylor Simmons Transplant Institute, Fort Worth, TX.

Meeting: 2015 American Transplant Congress

Abstract number: 60

Keywords: Glomerular filtration rate (GFR), Liver cirrhosis, Liver transplantation, Renal dysfunction

Session Information

Date: Sunday, May 3, 2015

Session Name: Concurrent Session: Optimizing Renal Outcomes in Liver Transplantation

Session Time: 2:15pm-3:45pm

 Presentation Time: 3:15pm-3:27pm

Location: Room 118-AB

Related Abstracts
  • Disparate Performance of Two Commonly Used Glomerular Filtration Rate Estimation Equations in Lung Transplant Patients
  • Comparison of Estimated Glomerular Filtration Rate Using Cystatin C Versus Creatinine in Pediatric Renal Transplant Patients

Background: Renal insufficiency is common in end-stage liver disease (ESLD) and is linked to survival in patients awaiting liver transplantation. Serum creatinine correlates poorly with measured glomerular filtration rate (GFR) in ESLD. Serum cystatin C may provide an accurate measure of renal function in this population. Methods: Prospective cohort study of consecutive patients with ESLD undergoing liver transplant evaluation. All patients underwent simultaneous assessment of serum cystatin C, serum creatinine, and 24-hour urine collection for creatinine clearance. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) cystatin C estimate for GFR was evaluated vs. serum creatinine in the assessment of renal dysfunction defined by simultaneous I125-iothalamate (Glofil-125) clearance. Results: 118 patients were prospectively enrolled and 98 completed the study. Patient characteristics included median age 58 (range 35-72), 65% male, 76% Caucasian, 46% chronic hepatitis C, and 29% hepatocellular carcinoma. Median GFR was 85.8 (range 3.8-203.6) determined by Glofil-125 and 22% had GFR<60. Females were more likely to have GFR<60 (35% vs. 16% of males, p=0.03). The CKD-EPI cystatin C estimate was superior to serum creatinine in discriminating renal dysfunction and was a strong predictor of measured GFR<60 (ROC AUC 0.92, 95% CI 0.83-1.00; p=0.008), GFR<50 (ROC AUC 0.96, 0.91-1.00; p=0.003), and GFR<40 (ROC AUC 0.95, 0.90-1.00; p=0.02). The relationship between CKD-EPI cystatin C and GFR remained highly significant in multivariate analysis involving demographic factors including gender (p<0.01). The inclusion of creatinine in estimation of GFR (CKD-EPI creatinine-cystatin C equation) did not improve discrimination of renal dysfunction (p=NS). Conclusion: Estimation of GFR using serum cystatin C accurately discriminates a wide range of renal dysfunction in patients with ESLD. Serum cystatin C may be used as a reliable marker of renal function in liver transplant candidates.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Gonzalez S, Trotter J, Szerlip H, Levy M, Chandrakantan A, Yango A, Rajagopal A, Barri Y, Rice K, Saim M, Melton L, Emmett M, Klintmalm G, Fischbach B. Estimation of Glomerular Filtration Rate With Serum Cystatin C Accurately Discriminates Renal Dysfunction in Liver Transplant Candidates With End-Stage Liver Disease [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/estimation-of-glomerular-filtration-rate-with-serum-cystatin-c-accurately-discriminates-renal-dysfunction-in-liver-transplant-candidates-with-end-stage-liver-disease/. Accessed April 20, 2021.

« Back to 2015 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Penis Transplantation: First U.S. Experience.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.