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American Transplant Congress abstracts

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Articles tagged "Liver preservation"

  • 2021 American Transplant Congress

    Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability

    S. Raigani1, S. Baptista1, A. Ohman2, J. Santiago2, I. Rosales1, M. Heaney2, J. Boylan2, T. Coe1, K. Uygun1, J. Sanders2, H. Yeh1

    1Transplant Surgery, Massachusetts General Hospital, Boston, MA, 2Pediatric Endocrinology, Brown University, Providence, RI

    *Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
  • 2021 American Transplant Congress

    Mitochondrial Transplant Minimizes Liver Ischemia Reperfusion Injury in Lean and Obese Mice

    C. Watkins1, G. Lamanilao1, C. Kuscu1, C. Kuscu1, J. F. Pierre2, J. Eason1, A. Bajwa1

    1Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, 2Department of Pediatrics - Divisions of Neonatology and Pediatric Obesity, The University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…
  • 2021 American Transplant Congress

    Normothermic-Hyperthermic Machine Perfusion Could Increase Response to Pharmacological Intervention in Mitigation of Liver Steatosis

    F. Zhou, M. Xu, G. A. Upadhya, Y. Lin, W. C. Chapman

    Surgery, Washington University in St. Louis, St. Louis, MO

    *Purpose: To study the feasibility of mitigating rat liver steatosis with ex-situ normothermic-hyperthermic machine perfusion using a multi-drug ‘defatting’ combination.*Methods: 16 male Zucker obese rats…
  • 2021 American Transplant Congress

    The Surgical Experience and Treatment Options for Hepatic Cystic Disease

    M. Crowley1, K. Robichaux2, A. Kumar1, J. Buggs3, J. Sokolich4

    1Morsani College of Medicine, University of South Florida, Tampa, FL, 2Honors College, University of South Florida, Tampa, FL, 3Transplant Surgery, Tampa General Hospital, Tampa, FL, 4Hepatobiliary Surgery, Valley Presbyterian Hospital, San Fernando Valley, CA

    *Purpose: Benign hepatic cysts may require surgical removal when symptomatic particularly in the setting of genetic disorders such as autosomal dominant polycystic kidney disease (ADPKD)…
  • 2021 American Transplant Congress

    Hypothermic Oxygenated Machine Perfusion Protects Against Cholangiocyte and Hepatocyte Injury and Mitigates Inflammation vs Static Cold Storage: Preliminary Results from a Single Center

    G. Panayotova, F. Paterno, M. McCarty, G. Dikdan, S. Simonishvili, Y. Qin, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera

    Transplant Surgery, Rutgers NJMS, Newark, NJ

    *Purpose: Hypothermic-oxygenated machine perfusion (HMP-O2) is a promising preservation technique with potential to mitigate ischemia/reperfusion injury and improve graft and patient outcomes. Here we present…
  • 2021 American Transplant Congress

    Role of Ferroptosis Inhibitors in Mitigating Ischemia-Reperfusion Injury in Marginal Livers Using a Novel Protect Model

    M. D. Nazzal, J. Van Nispen, A. Armstrong, V. Murali, E. Song, M. Voigt, A. Samaddar, E. Madsen, C. Manithody, J. Krebs, D. Blackall, D. Carpenter, C. Varma, J. Teckman, A. Jain

    Saint Louis University, Saint Louis, MO

    *Purpose: The discard rate of deceased donor livers (DDL) remains high at nearly 9% and incudes livers that are steatotic, old in age, and from…
  • 2021 American Transplant Congress

    Hepatocyte SIRT1 Suppresses Atf4-mediated Apoptosis Triggered by Cold Stress in Mouse and Human Liver Transplantation

    K. Kadono1, H. Hirao1, H. Kojima1, K. J. Dery1, J. Aziz1, X. Li2, J. W. Kupiec-Weglinski1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: The role of ER-stress or hepatocyte-specific SIRT1 signaling during donor liver cold preservation remains unknown. We employed a mouse OLT model and analyzed clinical…
  • 2021 American Transplant Congress

    Cross-Circulation for Extracorporeal Liver Support in a Swine Model

    W. K. Wu1, A. Tumen1, J. W. Stokes2, R. Ukita2, A. E. Hozain3, C. R. Flynn2, M. J. Lee3, J. R. Talackine2, N. L. Cardwell2, J. A. Reimer3, M. Pinezich3, C. Benson2, G. Vunjak-Novakovic3, S. P. Alexopoulos2, M. Bacchetta2

    1co-first authors, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Columbia University Medical Center, New York, NY

    *Purpose: Although machine perfusion has gained momentum as an organ preservation strategy in liver transplantation, significant organ shortages and waitlist mortality persist, highlighting unmet needs…
  • 2021 American Transplant Congress

    Single Cell RNA Sequencing Reveals a Global Increase in Inflammatory Gene Signature Following Normothermic Ex Vivo Liver Perfusion

    K. Carlson, J. Pavan-Guimaraes, B. Verhoven, J. Verhagen, F. Najmabadi, D. P. Al-Adra

    Surgery, University of Wisconsin, Madison, WI

    *Purpose: Normothermic ex vivo liver perfusion (NEVLP) provides an exciting system for improved organ preservation and optimized therapeutic agent delivery to a donor liver prior…
  • 2021 American Transplant Congress

    Indocyanine Green Fluorescence Imaging Allows Quantification of Ischemic Injury During Porcine Normothermic Ex Situ Perfusion

    T. Goto, Y. Noguchi, S. Ganesh, L. Mazilescu, T. Reichman, N. Selzner, M. Selzner

    Ajmera Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada

    *Purpose: Normothermic Ex Situ Liver Perfusion (NEsLP) is a novel preservation technique for the storage and assessment of grafts retrieved after Donation after Cardio-circulatory Death…
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