Date: Monday, June 3, 2019
Session Name: Poster Session C: Kidney: Cardiovascular and Metabolic
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Adiponectin was synthesized and expressed by adipocytes. However, recently it was suggested that adiponectin is also secreted and expressed by skeletal muscle. Decline of muscle strength is a predictor of mortality in the elderly and adiponectin levels are inversely associated with muscle strength. The present study evaluated the relationship between fasting serum adiponectin level and handgrip strength in renal transplant recipients.
*Methods: Fasting blood samples were collected from 90 renal transplant recipients. Handgrip strength (HGS) was measured using a Jamar Plus Digital Hand Dynamometer for assessment of muscle strength. Low muscle strength was defined as HGS less than 30 Kg for men and 20 Kg for women, according to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. Serum adiponectin levels were determined using a commercially available enzyme immunoassay.
*Results: Forty-four renal transplant recipients (48.9%) had low handgrip strength, and they included a higher serum fasting glucose (P = 0.014) and lower serum adiponectin level (P < 0.001) compared with renal transplant recipients with normal handgrip strength. Female renal transplant recipients had higher serum adiponectin level (P = 0.021) compared with male renal transplant recipients. After adjusting for cofounders associated with low handgrip strength in these patients by multivariable logistic regression analysis, serum adiponectin level (Odds ratio (OR): 0.859, 95% confidence interval (CI): 0.794-0.928, P < 0.001) was independently associated with low handgrip strength in renal transplant recipients. The serum adiponectin level is also statistically significant in male renal transplant recipients (OR: 0.863, 95% CI: 0.765-0.975, P = 0.018) and female renal transplant recipients (OR: 0.738, 95% CI: 0.605-0.901, P = 0.003) after multivariablte logistic regression analysis.
*Conclusions: The serum fasting adiponectin level is negatively associated with low handgrip strength in renal transplant patients.
To cite this abstract in AMA style:Lee M, Hsu B. Hypoadiponectinemia is Associated with Low Handgrip Strength in Renal Transplant Recipients [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/hypoadiponectinemia-is-associated-with-low-handgrip-strength-in-renal-transplant-recipients/. Accessed November 25, 2020.
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