Articles tagged "Kidney"

2016 American Transplant Congress
Reduced-Dose Cidofovir (CID) and CMV-Hyperimmune Globulin (CMVIg) for Ganciclovir-Resistant Cytomegalovirus: Effective and Kidney Friendly.
S. Patel, S. Kuten, J. Snyder, R. Knight, A. Gaber.
Houston Methodist Hospital, Houston, TX.
Ganciclovir resistant (GR) CMV is associated with an aggressive disease course and substantial morbidity. Furthermore, treatment options such as foscarnet and cidofovir are incredibly nephrotoxic.…
2016 American Transplant Congress
Ledipasvir/Sofosbuvir (LDV/SOF) for 12 or 24 Weeks Is Safe and Effective in Kidney Transplant Recipients with Chronic Genotype 1 or 4 HCV Infection.
S. Pol,¹ A. Aghemo,² L. Lin,³ R. Hyland,³ C. Yun,³ J. Spellman,³ M. Natha,³ D. Brainard,³ J. McHutchison,³ M. Bourlière,⁴ M. Peck-Radosavljevic,⁶ M. Michael,⁵ M. Colombo.²
¹Hopital Cochin, Paris, France; ²Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; ³Gilead Sciences Inc, Foster City; ⁴Hôpital Saint Joseph, Marseilles, France; ⁵Hannover Medical School, Hannover, Germany; ⁶Medical University of Vienna, Vienna, Austria.
Background and Aims: Interferon (IFN) and ribavirin (RBV) for the treatment of chronic hepatitis C (HCV) in kidney transplant recipients is complicated by the risk…
2016 American Transplant Congress
No Significant Impact of KAS on Prior Living Kidney Donors' Access to Timely Transplant of High Quality Kidneys.
J. Wainright,¹ A. Kucheryavaya,¹ M. Aeder,² D. Klassen,¹ D. Stewart.¹
¹UNOS, Richmond, VA; ²UH Case MC, Cleveland, OH.
BackgroundPrior living donors (PLDs) who develop ESRD post-donation have received priority on the kidney (KI) waiting list (WL) since 9/2/96. The new Kidney Allocation System…
2016 American Transplant Congress
A Quantitative CD45 Immunohistochemical Assay Allows Precise and Reproducible Measurement of Inflammation in Renal Transplant Biopsies.
V. Walavalkar,¹ S. Bowman,¹ L. Laszik,¹ D. Ikle,² S. Chandran,¹ F. Vincenti,¹ Z. Laszik.¹
¹UCSF, San Francisco, CA; ²Rho, Chapel Hill, NC.
Purpose: Total inflammation (TI) is an important variable for the pathologic work-up of transplant kidney biopsies (TxBx) in the Banff schema. However, current standard pathologic…
2016 American Transplant Congress
Muscle Density Is Associated with Mortality Among Kidney Waitlist Candidates.
R. Reed,¹ S. Nair,² G. Smith,¹ C. Lewis,¹ J. Terry,² J. Carr,² J. Locke.¹
¹School of Medicine, University of Alabama at Birmingham, Birmingham, AL; ²School of Medicine, Vanderbilt University, Nashville, TN.
Background: Morphometric assessments, such as muscle density and body fat distribution, have emerged as strong predictors of cardiovascular risk and post-operative morbidity and mortality. To…
2016 American Transplant Congress
Hydrogen Sulfide Treatment Mitigates Donor Tissue Necrosis During Prolonged Cold Storage and Improves Survival Following Allogeneic Renal Transplantation.
I. Lobb,^1,3 W. Liu,² J. Jiang,³ D. Lian,³ A. Sener.^1,3,4
¹Microbiology and Immunology, Western University Canada, London, ON, Canada; ²Pathology, Western University Canada, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴Surgery, Western University Canada, London, ON, Canada.
Organ procurement is inherently associated with ischemia-reperfusion injury (IRI), resulting from loss and subsequent restoration of blood flow, which is detrimental to short- and long-term…
2016 American Transplant Congress
c-Kit⁺ Cells Are Kidney-Specific Progenitor/Stem Cells with Regenerative Potential.
S. Abreu Gomes,¹ G. Goss,² B. Goldstein,² B. Seidler,³ D. Saur,³ J. Hare,² E. Bevilaqua Rangel.¹
¹Albert Einstein Hospital, Sao Paulo, SP, Brazil; ²University of Miami, Miami; ³Medizinische Klinik, Technische Universität München, Munich, Germany.
Introduction: Identification of progenitor/stem cell populations in mammalian tissues is important for therapeutic applications and for understanding biological processes. We recently reported that c-Kit+ cells…
2016 American Transplant Congress
Would Transplanting Kidneys Currently Being Discarded in the US Place Programs at Risk for Regulatory Review?
J. Snyder, N. Salkowski, B. Thompson, A. Wey, A. Israni, B. Kasiske, S. Leppke.
Scientific Registry of Transplant Recipients, Minneapolis.
In the US in 2014, 17,188 potential kidneys were available from 8594 deceased donors (2014 SRTR/OPTN Annual Data Report). Of these, 25% were not recovered…
2016 American Transplant Congress
Arterial Hypertension After Renal Transplantation in Pediatric Patients: An Analysis of CERTAIN Registry.
R. Sugianto,¹ E. Wühl,² B. Schmidt,¹ K. Krupka,² B. Höcker,² B. Tönshoff,² A. Melk.¹
¹Children's Hospital, Hannover Medical School, Hanover, Germany; ²Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany.
BackgroundOur study aimed to describe the prevalence of hypertension & blood pressure (BP) control as well as influencing factors in pediatric renal transplant patients.MethodCasual BP…
2016 American Transplant Congress
A Novel Quantitative CD45 Immunofluorescence Assay Can Measure Inflammatory Load in Renal Transplant Biopsies with Excellent Reproducibility and Repeatability.
Z. Laszik,¹ D. Dobi,¹ L. Laszik,¹ D. Ikle,² S. Chandran,¹ F. Vincenti.¹
¹UCSF, San Francisco, CA; ²Rho, Chapel Hill, NC.
Purpose: The interobserver reproducibility of the current standard semiquantitative (Banff) grading of inflammation in renal transplant biopsies (TxBx) is suboptimal. We have recently developed a…