Articles tagged "Kidney"

2021 American Transplant Congress
Mitigating the Adverse Impact of Broader Kidney Sharing with Hospital-based Machine Perfusion
Y. Yushkov, B. R. Schleich, T. Carrea, V. Wadhera, M. J. Goldstein
Hackensack University Medical Center, Hackensack, NJ
*Purpose: The new UNOS kidney allocation changes effective December 2020 will be removing the geographic limits of donation service areas (DSA) and UNOS regions favoring…
2021 American Transplant Congress
White, Older Men Are Less Affected by the Changes of the Covid-19 Pandemic
R. J. Berkowitz, A. Daud, S. Brietigam, T. S. Taylor, J. Carter, M. A. Callegari, B. Borja-Cacho, J. C. Caicedo, D. Simpson, D. P. Ladner
Surgery, Northwestern Medicine, Chicago, IL
*Purpose: This study explores quality of life and lifestyle changes due to the COVID-19 pandemic among pre- and post- liver (LT) and kidney (KT) transplant…
2020 American Transplant Congress
Activated CD27⁺CD21^– Subset Dominate the Memory B Cell Response During Antibody-Mediated Rejection of Kidney Allografts
K. Louis¹, E. Bailly¹, C. Macedo¹, M. Marrari¹, M. Yamada¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm UMR 976, Paris, France
*Purpose: The role of alloreactive memory B (mB) cells in the pathogenesis of antibody-mediated rejection (ABMR) is increasingly recognized. Yet, a comprehensive characterization of mB…
2020 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies are Associated with Younger Age and Renal Dysfunction in Pediatric Kidney Transplantation
M. Pearl¹, E. T. Chambers², A. Kirk², R. Garro³, B. L. Warshaw³, P. Grimm⁴, R. Ettenger¹, E. Reed¹
¹UCLA, Los Angeles, CA, ²Duke, Durham, NC, ³Emory, Atlanta, GA, ⁴Stanford, Stanford, CA
*Purpose: The significance of non-HLA antibodies in renal transplantation remains unclear. In small single center retrospective studies, angiotensin II type 1 receptor antibody (AT1R-Ab) has…
2020 American Transplant Congress
Single Cell Analysis of Living Donor Kidneys Characterizes Resident Parenchymal and Immune Populations in Male and Female Donors
C. McEvoy¹, J. Szusz², S. Clotet-Freixas¹, J. An², S. Crome², A. Konvalinka¹
¹Toronto General Hospital Research Institute and UHN Transplant Centre, UHN, Toronto, ON, Canada, ²Toronto General Hospital Research Institute, Dept. of Immunology, UHN Transplant, Toronto, ON, Canada
*Purpose:Understanding the molecular profiles and individual contributions of kidney parenchymal and resident/infiltrating immune cells during homeostasis would facilitate development of treatments for kidney graft disease.…
2020 American Transplant Congress
Incidence of Antibody Mediated Rejection in Living Kidney Transplant Recipients with Sensitizing History
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Regulation, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: A donor-reactive alloimmune memory response can arise from prior exposure to foreign human leukocyte antigen by sensitization history in transplant recipients. Assessing risk levels…
2020 American Transplant Congress
Twice Weekly Valganciclovir for Cytomegalovirus Infection Prophylaxis in Kidney Transplant Recipients with Delayed Graft Function on Hemodialysis
S. A. Mehta¹, A. Katz², R. Dieter², P. Jen², J. Siegfried², J. Papadopoulos², T. Lewis²
¹Infectious Diseases, NYU Langone Health, New York, NY, ²Pharmacy, NYU Langone Health, New York, NY
*Purpose: The incidence of cytomegalovirus (CMV) remains high in the first year following kidney transplantation. Valganciclovir (VGC) is commonly prescribed in the early post-operative period…
2020 American Transplant Congress
XBP1 Modulates Endoplasmic Reticulum and Mitochondria Crosstalk via Regulating NLRP3 Inflammasome in Renal Ischemia/Reperfusion Injury
H. Ni¹, Y. Liu¹, W. Deng¹, J. Zhang², J. Xu¹, W. Zeng¹, N. Gong², Y. Miao¹
¹Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Institute of Organ Transplantation, Key Laboratory of the Ministry of Health and the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: This study aims to investigate the molecular mechanism and function of X-box binding protein 1 (XBP1)- NLR family pyrin domain-containing 3 (NLRP3) signaling which…
2020 American Transplant Congress
Calcineurin Inhibitor Withdrawal is the Significant Risk Factor for De Novo DSA Production in Living Donor Kidney Transplantation
T. Hiramitsu¹, T. Tomosugi¹, K. Futamura¹, M. Okada¹, N. Goto¹, S. Narumi¹, K. Uchida², Y. Watarai¹
¹Nagoya Daini Red Cross Hospital, Nagoya Aichi, Japan, ²Masuko Memorial Hospital, Nagoya Aichi, Japan
*Purpose: For the long graft survival in the kidney transplantation, chronic antibody mediated rejection (CAMR) due to the de novo donor specific antibody (dnDSA) is…
2020 American Transplant Congress
Impact of Kidney Donor Profile Index (KDPI) on Long-Term Outcomes in Deceased Donor Renal Transplant Recipients with Donor Acute Kidney Injury
A. Brar¹, M. Salifu², D. Adey¹, A. Gruessner²
¹University of California, San Francisco, San Francisco, CA, ²SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Kidneys with donor acute kidney injury (AKI) are discarded at a higher rate. The purpose of the study is to assess long term renal…