Articles tagged "Kidney"

2021 American Transplant Congress
Efficacy of MAU868, a Novel BKV Neutralizing Monoclonal Antibody (mAb), for the Treatment of Severe BK Virus Nephropathy (BKVN) After Kidney Transplant
S. C. Jordan¹, N. Ammerman², M. Toyoda³, K. Lim², J. R. Abend⁴, A. Patick⁵, M. R. Hodges⁵, A. Vo², S. J. Kovacs⁶
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, West Hollywood, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ³Cedars Sinai Medical Ctr, Los Angeles, CA, ⁴Novartis Institutes for BioMedical Research, Virology Research, Emeryville, CA, ⁵Amplyx Pharmaceuticals, San Diego, CA, ⁶Novartis Institutes for BioMedical Research, Translational Medicine, East Hanover, NJ
*Purpose: BKV reactivation leading to nephropathy and allograft loss in kidney transplant (KT) recipients remains a clinical significant concern. No specific or effective anti-BKV therapies…
2021 American Transplant Congress
Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells
C. Albert¹, L. G. Bracaglia¹, A. Koide², J. DiRito¹, T. Lysyy¹, C. Edwards¹, J. T. Langford¹, D. Haakinson¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober¹, W. M. Saltzman¹, S. Kiode², G. Tietjen¹
¹Yale University, new haven, CT, ²Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, ³University of Cambridge, Cambridge, United Kingdom
*Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
2020 American Transplant Congress
Conversion to a Belatacept Based Immunosuppression Regimen in Renal Transplant Recipients
K. Paplaczyk, K. Cunningham, C. D'Agostino, D. Pinelli, J. Schulte, A. Shetty
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Belatacept, a co-stimulation blocker, is an alternative anti-rejection agent that may avoid nephrotoxic or intolerable adverse effects of calcineurin inhibitor (CNI) or mammalian target…
2020 American Transplant Congress
Genetic Testing of Living Related Donors for Inherited Renal Disease Improves Evaluation and Promotes Informed Choice of At-Risk Living Donors
C. P. Thomas¹, M. E. Freese¹, D. A. Katz²
¹Internal Medicine, University of Iowa, Iowa City, IA, ²Surgery, University of Iowa, Iowa City, IA
*Purpose: Living kidney donors (LKDs) with a family history of kidney disease are at higher risk of end-stage renal disease (ESRD) compared to LKDs without…
2020 American Transplant Congress
Mental Health of Unspecified Anonymous Living Kidney Donors after Donation
W. Zuidema¹, S. Ismail², J. Wetering van de¹, L. Raalten van², W. Weimar¹, E. Massey¹
¹Internal Medicine, Erasmus MC, Rotterdam, Netherlands, ²Psychiatry, Erasmus MC, Rotterdam, Netherlands
*Purpose: Aim: Anonymous living kidney donors donates to an unknown stranger. These donors undergo psychosocial assessment to minimize likelihood of psychological harm from donation. The…
2020 American Transplant Congress
Predicting Renal Graft Function Post Transplantation Using Clinical and Biological Features Supported by Machine Learning Algorithms
Y. Gao¹, Y. Cui¹, C. Kuscu², C. Kuscu², L. Gallon³, A. Bajwa², E. Akalin⁴, J. D. Eason², D. Maluf², V. Mas²
¹Department of Genetics, University of Tennessee Health Science Center, Memphis, TN, ²Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ³Northwestern University, Chicago, IL, ⁴Albert Einstein Medical College, New York, NY
*Purpose: Predicting renal function post transplantation is a frequent challenge impacting physician decisions and patient quality of life. We aimed to develop a composite score…
2020 American Transplant Congress
Utilization of Kidneys with Microthrombi and Acute Kidney Injury
W. De Faria, E. Shipman, G. Ciancio, G. Guerra
Miami Transplant Institute, Miami, FL
*Purpose: Kidneys continue to be discarded for reasons such as surgical damage, high kidney donor profile index (KDPI), prolonged cold ischemia time, and acute kidney…
2020 American Transplant Congress
Ethical and Financial Consequences of Incidental Radiological Findings During Living Kidney Donor Evaluation
R. Mao, R. Kulkarni, C. Duran, H. Stevenson-Lerner, M. Mujtaba, J. Fair, M. Kueht
University of Texas Medical Branch, Galveston, TX
*Purpose: Living kidney donation (LKD) provides a unique situation in that diagnostic studies are ordered on a presumably healthy individual. Literature has shown that preoperative…
2020 American Transplant Congress
Simultaneously Detection of ddcfDNA in Plasma and Urine Assist to Determine the Type of Rejection in Renal Transplant Patients
D. Cheng¹, F. Liu², H. Liu², T. Jiang², Y. Zhou³, L. Shu², X. Li¹, K. Xie¹, X. Ni¹, J. Chen¹, J. Ge², Z. Liu¹, H. Shi³
¹Jinling Hospital Nanjing University, Nanjing, China, ²AlloDx, Shanghai; Suzhou, China, ³Jiangsu University, Zhenjiang, China
*Purpose: The correct diagnosis and treatment of acute rejection (ABMR and TCMR) are the key to the long-term survival after renal transplantation. Renal biopsy is…
2020 American Transplant Congress
Living Donor Nephrectomy Outcomes in the Us: Analysis of HCUP Data
M. S. Gharibdousti¹, M. T. Khasawneh², A. L. Friedman³
¹Research, Live On NY, Brooklyn, NY, ²System Science and Industrial Engineering, Binghamton University, Binghamton, NY, ³Preservation, Live On NY, New York, NY
*Purpose: To identify clinical outcomes and complications of living donor nephrectomies in the US from 2008 - 2015.*Methods: A retrospective analysis of 2008-2015 discharge data…