Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Effects of Immunosuppression and Sun Exposure on Immune Cell Populations in Skin and Blood of Kidney Transplant Recipients.
M. Burke,¹ L. Nahum,⁴ N. Isbel,¹ R. Carroll,³ H. Soyer,¹ R. Francis,¹ J. Bridge,¹ C. Staatz,² J. Wells.¹
¹Translational Research Institute, Brisbane, Australia; ²University of Queensland, Brisbane, Australia; ³Royal Adelaide Hospital, Adelaide, Australia; ⁴Ben Gurion University of the Negev, Beersheba, Israel.
BackgroundKidney transplant recipients (KTR) receiving sirolimus accrue fewer skin cancers than KTR receiving calcineurin inhibitor (CNI) based immunosuppression, potentially due to effects of sirolimus and…
2016 American Transplant Congress
Associations Between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes.
S. Mansour,¹ J. Puthumana,¹ P. Reese,² I. Hall,¹ M. Doshi,³ F. Weng,⁴ B. Schröppel,⁵ H. Thiessen-Philbrook,^1,6 M. Bimali,¹ C. Parikh.¹
¹Nephrology, Yale University School of Medicine, New Haven, CT; ²Renal-Electrolyte and Hypertension, University of Pennsylvania, Philadelphia, PA; ³Wayne State University, Detroit, MI; ⁴Saint Barnabas Medical Center, Livingston, NJ; ⁵Nephrology, University Hospital, Ulm, Germany; ⁶Nephrology, Western University, London, ON, Canada.
Current assessments of deceased donor kidneys lack precision in predicting recipient graft function. Mouse models have demonstrated that monocyte chemoattractant protein-1 (MCP-1) has a pivotal…
2016 American Transplant Congress
“Day 2 Discharge” After Kidney Transplantation: Complications, Health Care Utilization, and Long-Term Clinical Outcomes.
A. Mathur, N. Katariya, A. Welu, J. Chang, R. Heilman, A. Singer, H. Khamash, H. Chakkera, W. Hewitt, D. Haakinson, M. Maningo-Salinas, E. Oakley, A. Moss, K. Reddy.
Transplant Center, Mayo Clinic, Phoenix.
Background: Reducing kidney transplant length of stay is a priority for many stakeholders. We aimed to determine whether very early discharge – on or before…
2016 American Transplant Congress
Clonal Expansion of Donor-Specific Tregs Following Combined Kidney and Bone Marrow Transplantation.
T. Savage,¹ S. Dewolf,¹ A. Obradovic,¹ S. Lau,¹ J. Zuber,¹ L. Turka,^2,3 Y. Shen,¹ M. Sykes.¹
¹Columbia University, New York; ²Massachusetts General Hospital, Boston; ³Immune Tolerance Network, Boston.
HLA-mismatched allograft tolerance was intentionally induced via combined kidney and bone marrow transplant (CKBMT) in two ITN protocols (NKDO3 and ITN036ST), but the mechanisms of…
2016 American Transplant Congress
NK-Activating MCMV Strain Is Associated with Increased Murine Renal Transplant Injury.
M. Shimamura,¹ M. Li,² B. Chen,² J. George,² T. Schoeb.³
¹Vaccines and Immunity, Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH; ²Pediatric Infectious Diseases, Cardiothoracic Surgery, Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Pathology and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Background: CMV contributes to inferior longterm kidney transplant survival. In a murine model, NK cells infiltrate MCMV infected renal allografts in greater numbers than in…
2016 American Transplant Congress
Have We Gone Too Far Defining Performance Outliers? One-Third of Kidney Transplant Programs Now Identified for Low Performance within Three Years.
J. Schold,¹ C. Miller,¹ M. Henry,² L. Buccini,¹ S. Flechner,¹ D. Goldfarb,¹ E. Poggio,¹ K. Andreonni.³
¹Cleveland Clinic, Cleveland, OH; ²Ohio State University, Columbus, OH; ³University of Florida, Gainesville, FL.
Transplant center report cards developed by SRTR are publicly available and utilized for regulatory oversight and insurance contracting. There are significant associations of performance oversight…
2016 American Transplant Congress
Serum Bicarbonate and Long-Term Outcomes in Kidney Transplant Recipients.
S. Park,¹ E. Kang,¹ M. Han,¹ J. Park,¹ S. Yang,² S. Park,³ I. Jung,⁴ C. Lim,⁵ Y. Kim,¹ Y. Kim,⁶ J. Lee.⁵
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ²Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea; ⁴Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea; ⁵Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; ⁶Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.
Background: Metabolic acidosis indicated by low serum bicarbonate (TCO2) level has been known as a risk factor for mortality and progressive renal dysfunction in patients…
2016 American Transplant Congress
Utilization of HCV-Positive Donors' Kidneys: Potential Benefits in the Era of Direct Acting Antiviral (DAA) Therapy.
B. Amundsen,¹ M. Sise,² M. Lin,³ H. Deirawan,¹ E. Heher,² B. Kimball,¹ J. Markmann,¹ N. Elias.¹
¹Massachusetts General Hospital, Boston, MA; ²Massachusetts General Hospital, Boston, MA; ³Brigham and Women's Hospital, Boston, MA.
Organ shortage and expanding kidney waiting list fostered utilization of HCV positive donors' organs (HCVD+). HCVD+ kidneys have slightly worse long term outcomes compared with…
2016 American Transplant Congress
Impact of Machine Perfusion on Long-Term Kidney Transplant Outcomes.
S. Sandal,^1,2 X. Luo,² A. Massie,² M. Cantarovich,¹ D. Segev.²
¹MUHC, Montreal, Canada; ²JHU, Baltimore.
Machine perfusion (MP) has been shown to decrease DGF rates in kidney transplant (KT) recipients when compared with static cold storage (CS). However, there is…
2016 American Transplant Congress
Frailty in KT Recipients of All Ages.
M. McAdams-DeMarco, H. Ying, I. Olorundare, E. King, D. Segev.
Johns Hopkins, Baltimore.
Background: Among KT recipients, frailty increases the risk of DGF, early hospital readmission and mortality. While it is clear that frail KT recipients represent a…