Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Detecting Renal Allograft Inflammation Using Quantitative Urine Metabolomics and CXCL10.
J. Ho,¹ A. Sharma,² R. Mandal,³ D. Wishart,³ C. Wiebe,¹ L. Storsley,¹ M. Karpinski,¹ I. Gibson,⁴ P. Nickerson,¹ D. Rush.¹
¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Pediatrics & Child Health, University of Manitoba, Winnipeg, MB, Canada; ³Biological Sciences, University of Alberta, Edmonton, AB, Canada; ⁴Pathology, University of Manitoba, Winnipeg, MB, Canada.
Background. We studied urine metabolomics (UM) alone or combined with urine CXCL10 to non-invasively detect cellular infiltrates in renal allograft biopsies.Methods. Urines (n=137) were obtained…
2016 American Transplant Congress
Removing Geographic and Financial Barriers for Directed Living Kidney Donations: Lessons from Kidney Paired Donation.
M. Aeder,¹ R. Leishman,² D. Stewart.²
¹Univ Hosp Case Med Ctr, Cleveland, OH; ²UNOS, Richmond, VA.
Living donor (LD) kidney (K) transplants (Tx), which peaked at 6647 in 2004 (42.5% of tx), decreased by 2014 to 5538 (32.4% of tx). Although…
2016 American Transplant Congress
Pre-Transplant Cardiovascular Risk Factors Affect Kidney Allograft Survival: A Multi-Center Study in Korea.
J. An,^1,2 S. Ahn,³ E. Bae,² E. Kang,² H.-L. Kim,⁴ Y.-J. Kim,⁵ Y. Oh,^1,2 C. Lim,^1,2 Y. Kim,² Y. Kim,⁶ J. Lee.^1,2
¹Division of Nephrology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ³Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, Korea; ⁴Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; ⁵Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ⁶Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.
Background - Pre- or post-transplant cardiovascular (CV) risk factors affect the development of CV events even after successful kidney transplantation (KT). However, the impact of…
2016 American Transplant Congress
IL2 and IL-15 Rescue TEMRA CD8 T Cells from Mitochondrial Dysfunction Associated Senescence Through a p38MAPK Dependent Pathway and Foster Their Pathogenic Potential.
G. Tilly,^1,2 M. Yap,^1,2 M. Giral,^1,2,3 C. Pecqueur,⁴ S. Brouard,^1,3 N. Degauque.^1,3
¹UMR1064, INSERM, Nantes, France; ²Université de Nantes, Nantes, France; ³ITUN, CHU de Nantes, Nantes, France; ⁴UMR892, INSERM, Nantes, France.
Background & Study Aim. We recently showed that an accumulation of highly differentiated TEMRA CD8 T cells in kidney transplant recipients with a stable graft…
2016 American Transplant Congress
Successful Transplantation in ABO- and HLA-Incompatible Kidney-Transplant Patients.
L. Rostaing, N. Congy, A. Allal, L. Esposito, F. Sallusto, N. Congy, X. Doumerc, B. Debiol, N. Kamar.
Néphrologie et Transplantation d'Organes, CHU Rangueil, Toulouse, France; INSERM U 563, CHU Purpan, Toulouse, France; Faculté de Médecine de Rangueil, Université Toulouse III Paul Sabatier, Toulouse, France; INSERM U1043 CNRS UMR 5282, CHU Purpan, Toulouse, France.
Introduction: ABO-incompatible (ABOi) and HLA-incompatible (HLAi) kidney transplantation using living donors is common place; however, few data have reported on the outcomes of ABOi/HLAi living-kidney…
2016 American Transplant Congress
Pre-Formed AT1R Antibodies Are Associated with Rejection After Kidney Transplantation.
D. Kim, P. Warner, K. Nelson, I. Gimferrer, C. Johnson, C. Blosser, R. Bakthavatsalam, N. Leca.
Nephrology, University of Washington, Seattle.
Antibody mediated injury is a significant contributor to rejection and allograft damage. Non-HLA antibodies have been increasingly recognized in association with graft dysfunction. Our goal…
2016 American Transplant Congress
The Impact of Allograft Rejection on DNA Methylation After Kidney Transplantation.
K. Boer, E. de Wit, D. Hesselink, L. Hofland, M. Betjes, C. Baan.
ErasmusMC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Introduction DNA methylation is a well-known epigenetic mechanism which plays a critical role in cell function by regulating gene expression. Variations in DNA methylation are…
2016 American Transplant Congress
Arteriolar Hyalinosis on Renal Transplant Protocol Biopsies Is Not Associated with Tacrolimus Exposure.
S. Yilmaz,¹ D. Shaffer,² Y. Qazi,³ F. Shihab,⁴ K. McCague,⁵ D. Patel,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, AB, Canada; ²Vanderbilt University, Nashville, TN; ³University of Southern California, Los Angeles, CA; ⁴University of Utah, Salt Lake City, UT; ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁶University of California San Francisco, San Francisco, CA.
Previous studies have implicated the development of arteriolar hyalinosis (AH) following kidney transplantation to chronic calcineurin inhibitor nephrotoxicity. Here, we examined the association between tacrolimus…
2016 American Transplant Congress
Association Between Pretransplant Body Mass Index and Outcomes in Patients Undergoing Living Kidney Transplantation: A Consideration of Gender Differences.
M. Okumi,¹ K. Unagami,¹ M. Furusawa,¹ T. Hirai,¹ Y. Okabe,² K. Masutani,³ T. Shimizu,¹ K. Omoto,⁴ H. Ishida,¹ T. Kitazono,³ K. Tanabe,¹ The Japan Academic Consortium of Kidney Transplantation (JACK).
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Surgery, Kyusyu University, Fukuoka, Japan; ³Medicine and Clinical Science, Kyusyu University, Fukuoka, Japan; ⁴Urology, Todachuo General Hospital, Saitama, Japan.
[lsaquo]Background[rsaquo]There is epidemiologic evidence of an association between elevated body mass index (BMI), the progression of cardiovascular disease (CVD), and end-stage renal disease (ESRD). For…
2016 American Transplant Congress
Impact of Social Support on Feelings of Powerlessness and Attitudes Towards the Kidney Transplant in Long-Term Inner City Recipients.
S. Wu, A. Brar, M. Markell.
Medicine, SUNY Downstate Medical Center, Brooklyn, NY.
Psychosocial factors play an important role in the post-transplant period, affecting adherence and quality of life. We investigated the relationships between social support, attitude towards…