Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Mapping Heterogeneity in Antibody-Mediated Rejection Using Molecular Phenotypes and Archetype Analysis.
J. Reeve,¹ P. Halloran.^1,2
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada; ²Medicine, University of Alberta, Edmonton, AB, Canada.
Archetype analysis is a method for identifying new relationships among samples without subdividing them into classes, finding a limited number of archetypical cases and calculating…
2016 American Transplant Congress
A Molecular Biopsy Test for Probability of Non-Adherence.
P. Halloran,^1,3 G. Einecke,² J. Reeve.¹
¹ATAGC, Edmonton, AB, Canada; ²Hannover Medical School, Hannover, Germany; ³Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…
2016 American Transplant Congress
Association of Pre-Transplant Midodrine Use and Complications After Kidney Transplantation.
T. Alhamad,¹ D. Brennan,¹ Z. Brifkani,¹ H. Xiao,² M. Schnitzler,² V. Dharnidharka,¹ D. Axelrod,³ D. Segev,⁴ K. Lentine.²
¹Washington University, St. Louis; ²Saint Louis University, St. Louis; ³Dartmouth Hitchcock Medical Center, Hanover; ⁴Johns Hopkins University, Baltimore.
Background: Midodrine is increasingly prescribed to decrease the severity and complications of hypotension in dialysis patients. The impacts of midodrine use before kidney transplantation on…
2016 American Transplant Congress
Non-Invasive – Minimalistic Approach Using Cell-Free MicroRNAs in Paired Plasma and Urine Samples for Early Diagnosis of Chronic Renal Allograft Dysfunction.
S. Bontha,¹ R. Gehrau,¹ E. Rhone,¹ A. King,² L. Gallon,³ K. Brayman,¹ D. Maluf,¹ V. Mas.¹
¹Surgery, UVA, Charlottesville, VA; ²VCU, Richmond; ³NWU, Chicago.
Background: Reducing use of tissue biopsy by efficiently using non-invasive samples for continuous monitoring and evaluation of graft function would be ideal. Reports indicate continuous…
2016 American Transplant Congress
Phenotype and Outcome of Antibody-Mediated Rejection Due to Pre-Existing and De Novo DSA in Kidney Recipients.
O. Aubert,¹ A. Loupy,¹ L. Hidalgo,² J. Reeve,³ D. Glotz,¹ C. Legendre,¹ C. Lefaucheur,¹ P. Halloran.³
¹Paris Research Center for Organ Transplantation, Paris, France; ²University of Alberta, Edmonton, Canada; ³ATAGC, Edmonton, Canada.
Antibody-mediated rejection (ABMR) presents with either pre-existing or de novo DSA. The aim of the study was to compare the two ABMR phenotypes and their…
2016 American Transplant Congress
mRNA Expression of BAFF and APRIL Receptors Increases in Acute Rejection in Kidney Transplant Recipients.
M. Minz,¹ R. Dhital,¹ R. Minz,² A. Sharma,¹ R. Nada,³ S. Singh,¹ D. Kenwar.¹
¹Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India; ²Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India; ³Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Introduction:BAFF and APRIL are known survival and growth of B- cells.BAFF and APRIL share two receptors i-TACI and ii- BCMA. Additionally, BAFF has strong affinity…
2016 American Transplant Congress
Analysis of Broken Chains in Kidney Paired Donation During an 8 Year Period within the National Kidney Registry.
N. Cowan,¹ J. Sinacore,² H. Gritsch,¹ J. Veale.¹
¹Department of Urology, University of California - Los Angeles Medical Center, Los Angeles, CA; ²National Kidney Registry, Babylon, NY.
Purpose: Chain transplantation in kidney paired donation (KPD) offers the ability to facilitate multiple kidney transplants between incompatible pairs using a non-directed donor (NDD) to…
2016 American Transplant Congress
Predictors of Postoperative Cardiovascular Complications Until Three Months After Kidney Transplantation.
M. Slot,^1,2 J. van de Wetering,¹ M. Kho,¹ M. Betjes,¹ J. Roodnat.¹
¹Nephrology, Erasmus Medical Center, Rotterdam, Netherlands; ²Nephrology, VU Medical Center, Amsterdam, Netherlands.
Purpose: To identify factors involved in cardiac events within three months after renal transplantation.Methods: We conducted a chart review for all renal transplants (RT) performed…
2016 American Transplant Congress
IL2 and IL-15 Rescue TEMRA CD8 T Cells from Mitochondrial Dysfunction Associated Senescence Through a p38MAPK Dependent Pathway and Foster Their Pathogenic Potential.
G. Tilly,^1,2 M. Yap,^1,2 M. Giral,^1,2,3 C. Pecqueur,⁴ S. Brouard,^1,3 N. Degauque.^1,3
¹UMR1064, INSERM, Nantes, France; ²Université de Nantes, Nantes, France; ³ITUN, CHU de Nantes, Nantes, France; ⁴UMR892, INSERM, Nantes, France.
Background & Study Aim. We recently showed that an accumulation of highly differentiated TEMRA CD8 T cells in kidney transplant recipients with a stable graft…
2016 American Transplant Congress
Successful Transplantation in ABO- and HLA-Incompatible Kidney-Transplant Patients.
L. Rostaing, N. Congy, A. Allal, L. Esposito, F. Sallusto, N. Congy, X. Doumerc, B. Debiol, N. Kamar.
Néphrologie et Transplantation d'Organes, CHU Rangueil, Toulouse, France; INSERM U 563, CHU Purpan, Toulouse, France; Faculté de Médecine de Rangueil, Université Toulouse III Paul Sabatier, Toulouse, France; INSERM U1043 CNRS UMR 5282, CHU Purpan, Toulouse, France.
Introduction: ABO-incompatible (ABOi) and HLA-incompatible (HLAi) kidney transplantation using living donors is common place; however, few data have reported on the outcomes of ABOi/HLAi living-kidney…