Articles tagged "Kidney transplantation"

2022 American Transplant Congress
The Relative Association of Clinical Variables and Histologic Lesions with Molecular Rejection in Kidney Transplant Biopsies
M. L. Sikosana¹, J. Reeve², P. F. Halloran², INTERCOMEX Investigators³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³INTERCOMEX, Edmonton, AB, Canada
*Purpose: Availability of molecular assessment (MMDx) independent of conventional variables (time, clinical, histologic, and HLA antibody) presents an opportunity to re-assess the relative strength of…
2022 American Transplant Congress
Concordance of POLQ and PARP-1 Expression and MMEJ Type Viral Integration in the Progression of BKPyV-Associated Diseases
Y. Wang¹, Z. Yan¹, Y. Liu², J. Geng³, W. Deng¹, R. Xia¹, W. Zeng¹, J. Xu¹, C. Wu⁴, Y. Miao¹
¹Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, ³Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁴Departments of Urology & Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To reveal the mechanism of the increasing dominant position of integration, especially the microhomology-mediated end joint (MMEJ) form in the development of BK Polyomavirus…
2022 American Transplant Congress
Utility of Porcine Kidneys in Transplantation Model for Training General Surgery Residents
O. Eletta, V. Putatunda, D. Walls, C. Antwi-Buosiako, B. Perry, N. Maloney Patel, R. Pelletier, A. Bongu
Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
*Purpose: We sought to increase the opportunities for general surgery residents to hone their vascular anastomosis skills. Accordingly, we created a kidney transplant model using…
2022 American Transplant Congress
Top Molecules Associated with CLAD in Lung Transplants Are Shared Between Mucosal Biopsies, Transbronchial Biopsies, and Kidney Transplant Biopsies at Risk of Progression
M. Mackova¹, K. Halloran², P. F. Halloran¹, .. and the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) is a physiologic state with grave consequences for progression to failure but cannot be diagnosed by biopsy histology. We…
2022 American Transplant Congress
Temporal Trends of Optn Hope Act Variance Participation
A. Wilk¹, M. Green², C. Marsh³, N. Theodoropoulos⁴, R. Formica⁵, N. Turgeon⁶, A. Fox⁷, A. Wilhelm¹, D. Klassen¹
¹UNOS, Richmond, VA, ²UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ³Scripps Clinic & Scripps Green Hospital, La Jolla, CA, ⁴UMass Medical, Worcester, MA, ⁵Yale, New Haven, CT, ⁶UT Health Austin, Austin, TX, ⁷CUIMC/Presbyterian Hospital, New York, NY
*Purpose: The Organ Procurement and Transplantation Network (OPTN) created a research variance allowing for transplantation of HIV+ donor kidneys and livers into HIV+ recipients after…
2022 American Transplant Congress
Development of a Patient-Reported Outcome Measure of Neurological Side Effects from Immunosuppression in Kidney Transplant Recipients
C. Hurt¹, G. J. Greene¹, J. Friedewald², D. P. Ladner², A. Waterman³, D. Cella¹, D. Peipert¹
¹Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Surgery and J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: Though kidney transplant is the optimal treatment for most individuals with end stage kidney disease, recipients experience significant side effects associated with their required…
2022 American Transplant Congress
Recurrence of Focal Segmental Glomerulosclerosis After Kidney Transplantation According to Pre-Transplant Treatment
H. Kwon, S. Shin, Y. Kim
Department of general surgery, Asan Medical Center, Seoul, Korea, Republic of
*Purpose: Focal segmental glomerulosclerosis (FSGS) recurrence after kidney transplantation (KT) is a significant risk factor of graft failure. The recurrence of FSGS develops in 30%-60%…
2022 American Transplant Congress
Multidimensional Immunological Profiling of CMV Dnaemia in Kidney Transplant Recipients
H. Pickering¹, S. Sen², R. S. Ahn², Z. Qian¹, G. Sunga¹, M. LLamas¹, A. Hoffmann¹, M. Deng¹, S. Bunnapradist³, J. Schaenman⁴, D. W. Gjertson¹, M. Rossetti¹, E. Reed⁵
¹UCLA, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, CA, ³David Geffen School of Medicine, Los Angeles, CA, ⁴David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁵Univ of California LA, Los Angeles, CA
*Purpose: Human cytomegalovirus (CMV) infects over half the global population, leading to a mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals…
2022 American Transplant Congress
Fixed-Dose Rituximab for Pre-Transplant DSA in Kidney Transplant Recipients
K. Progar¹, K. Kurwicki², N. Nesselhauf³, J. Hagopian⁴, S. January⁵, H. Wijeweera⁶, M. McCloskey⁷, M. Merzkani⁸, R. Delos Santos⁹
¹Transplant, Barnes-Jewish Hospital, St. Louis, MO, ²SSM Health Saint Louis University Hospital, Saint Louis, MO, ³Barnes-Jewish Hospital, Edwardsville, IL, ⁴Pharmacy, University of Michigan, Ann Arbor, MI, ⁵Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, ⁶Washington University, Saint Louis, MO, ⁷Barnes-Jewish Hospital, St. Louis, MO, ⁸Washington University, St Louis, MO, ⁹Transplant, Washington University, St. Louis, MO
*Purpose: Donor specific antibodies (DSAs) occur in 15-30% of kidney transplant recipients (KTRs) and are associated with rejection and graft loss. Rituximab (RTX), an antiCD20…
2022 American Transplant Congress
Reduced CD45RA-CCR7- Tregs Subtypes in Highly Sensitised Patients Associates with a Failure to Regulate Memory IFNγ Production in Response to Donor Alloantigens
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitised (HS) patients exhibit worse long-term outcomes after kidney transplantation compared to non-sensitised patients. It has been hypothesised that regulatory T cells (Tregs)…