Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Top Molecules Associated with CLAD in Lung Transplants Are Shared Between Mucosal Biopsies, Transbronchial Biopsies, and Kidney Transplant Biopsies at Risk of Progression
M. Mackova¹, K. Halloran², P. F. Halloran¹, .. and the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) is a physiologic state with grave consequences for progression to failure but cannot be diagnosed by biopsy histology. We…
2022 American Transplant Congress
Temporal Trends of Optn Hope Act Variance Participation
A. Wilk¹, M. Green², C. Marsh³, N. Theodoropoulos⁴, R. Formica⁵, N. Turgeon⁶, A. Fox⁷, A. Wilhelm¹, D. Klassen¹
¹UNOS, Richmond, VA, ²UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ³Scripps Clinic & Scripps Green Hospital, La Jolla, CA, ⁴UMass Medical, Worcester, MA, ⁵Yale, New Haven, CT, ⁶UT Health Austin, Austin, TX, ⁷CUIMC/Presbyterian Hospital, New York, NY
*Purpose: The Organ Procurement and Transplantation Network (OPTN) created a research variance allowing for transplantation of HIV+ donor kidneys and livers into HIV+ recipients after…
2022 American Transplant Congress
Development of a Patient-Reported Outcome Measure of Neurological Side Effects from Immunosuppression in Kidney Transplant Recipients
C. Hurt¹, G. J. Greene¹, J. Friedewald², D. P. Ladner², A. Waterman³, D. Cella¹, D. Peipert¹
¹Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Surgery and J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: Though kidney transplant is the optimal treatment for most individuals with end stage kidney disease, recipients experience significant side effects associated with their required…
2022 American Transplant Congress
Recurrence of Focal Segmental Glomerulosclerosis After Kidney Transplantation According to Pre-Transplant Treatment
H. Kwon, S. Shin, Y. Kim
Department of general surgery, Asan Medical Center, Seoul, Korea, Republic of
*Purpose: Focal segmental glomerulosclerosis (FSGS) recurrence after kidney transplantation (KT) is a significant risk factor of graft failure. The recurrence of FSGS develops in 30%-60%…
2022 American Transplant Congress
Multidimensional Immunological Profiling of CMV Dnaemia in Kidney Transplant Recipients
H. Pickering¹, S. Sen², R. S. Ahn², Z. Qian¹, G. Sunga¹, M. LLamas¹, A. Hoffmann¹, M. Deng¹, S. Bunnapradist³, J. Schaenman⁴, D. W. Gjertson¹, M. Rossetti¹, E. Reed⁵
¹UCLA, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, CA, ³David Geffen School of Medicine, Los Angeles, CA, ⁴David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁵Univ of California LA, Los Angeles, CA
*Purpose: Human cytomegalovirus (CMV) infects over half the global population, leading to a mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals…
2022 American Transplant Congress
Fixed-Dose Rituximab for Pre-Transplant DSA in Kidney Transplant Recipients
K. Progar¹, K. Kurwicki², N. Nesselhauf³, J. Hagopian⁴, S. January⁵, H. Wijeweera⁶, M. McCloskey⁷, M. Merzkani⁸, R. Delos Santos⁹
¹Transplant, Barnes-Jewish Hospital, St. Louis, MO, ²SSM Health Saint Louis University Hospital, Saint Louis, MO, ³Barnes-Jewish Hospital, Edwardsville, IL, ⁴Pharmacy, University of Michigan, Ann Arbor, MI, ⁵Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, ⁶Washington University, Saint Louis, MO, ⁷Barnes-Jewish Hospital, St. Louis, MO, ⁸Washington University, St Louis, MO, ⁹Transplant, Washington University, St. Louis, MO
*Purpose: Donor specific antibodies (DSAs) occur in 15-30% of kidney transplant recipients (KTRs) and are associated with rejection and graft loss. Rituximab (RTX), an antiCD20…
2022 American Transplant Congress
Reduced CD45RA-CCR7- Tregs Subtypes in Highly Sensitised Patients Associates with a Failure to Regulate Memory IFNγ Production in Response to Donor Alloantigens
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitised (HS) patients exhibit worse long-term outcomes after kidney transplantation compared to non-sensitised patients. It has been hypothesised that regulatory T cells (Tregs)…
2022 American Transplant Congress
NK Cells in Kidney Allograft Antibody-mediated Rejection Display Increased Proliferation, IL-21 Responsiveness, Type-1 Activation, and Cytotoxic Profile
E. Bailly¹, C. Macedo¹, K. Louis², X. Gu¹, B. Ramaswami¹, M. Lucas¹, C. Bentlejewski¹, A. Zeevi¹, P. Randhawa¹, C. Lefaucheur², D. Metes¹
¹Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Paris, France
*Purpose: The role of NK cell during antibody-mediated rejection (ABMR) has been previously recognized, but an in-depth characterization of pathways that contribute to such immune…
2022 American Transplant Congress
A Signature of Tolerance Which Identifies Subclinical Rejection-Free Patients at One Year After Kidney Transplantation
R. Danger¹, L. Le Berre¹, M. Cadoux¹, C. Kerleau¹, P. Guérif¹, E. Morelon², O. Thaunat², C. Legendre³, D. Anglicheau³, K. Renaudin¹, M. Giral¹, S. Brouard¹
¹Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, ITUN, Nantes Université, CHU Nantes, Inserm, Nantes, France, ²Edouard Herriot Hospital, Hospices Civils de Lyon, Inserm U1111, Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), Lyon, France, ³APHP, Necker-Enfants Malades Institute, Inserm, Paris University, Paris, France
*Purpose: Spontaneous and rare cases of patients undergoing a functional renal transplant in the absence of immunosuppression represent a particular situation of immune tolerance. We…
2022 American Transplant Congress
Social Determinants of Health Are Associated with Pre-Emptive Wait Listing and Do Not Fully Account for Racial Gap in Early Access to the Waitlist
A. M. Zehner¹, L. A. Cartwright², T. Mupfudze², T. Wilson², A. Placona², B. Carrico²
¹Research Department, United Network for Organ Sharing, Richmond, VA, ²Research Department, UNOS, Richmond, VA
*Purpose: We leveraged a novel data linkage of candidate-level indicators of social determinants of health (SDOH) among kidney waitlist candidates in the United States to…