Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Clazakizumab® (anti-il-6) Desensitization in Highly-HLA Sensitized Patients Awaiting Kidney Transplant (nct03380962): Long-Term Follow Up
A. Vo¹, J. Tang¹, N. Ammerman¹, E. Huang¹, X. Zhang², M. Haas³, A. Peng¹, R. Najjar¹, S. Williamson¹, C. Meyers¹, S. Sethi¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA, ³Pathology, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6 is a cytokine critical for B-cell activation and IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6.…
2022 American Transplant Congress
External Validation of the Abbreviated Ibox Scoring System at One-Year Post Kidney Transplant as a Surrogate Endpoint for Death-Censored Graft Survival
A. Klein¹, L. Kosinski², R. Muse², A. Loupy³, O. Aubert³, G. Divard³, M. Stegall⁴, I. Helanterä⁵, W. E. Fitzsimmons¹, I. O'Doherty¹
¹Transplant Therapeutics Consortium, Critical Path Institute, Tucson, AZ, ²Critical Path Institute, Tucson, AZ, ³Paris Transplant Group, Paris, France, ⁴Mayo Clinic, Rochester, MN, ⁵Helsinki University Hospital, Helsinki, Finland
*Purpose: The Transplant Therapeutics Consortium seeks to translate the iBox from Loupy et al., 2019 into a surrogate endpoint for five-year death-censored graft survival after…
2022 American Transplant Congress
Recurrence of Membranous Nephropathy After Kidney Transplantation – TANGO Consortium
F. Hullekes¹, A. Uffing¹, L. Riella¹, P. Cravedi²
¹Harvard Medical School, Boston, MA, ²Mount Sinai, New York, NY
*Purpose: Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Several breakthroughs in recent decades, including the identification of anti-PLA2R Abs, aided…
2022 American Transplant Congress
A Multi-Center Study Assessing the Association of Frailty with Infection in Kidney Transplant Recipients
M. Malinis¹, M. Abidi², E. Benamu², N. Jakharia³, N. Law⁴, R. Sigler⁴, R. Nog⁵, S. Olivier⁵, S. Taimur⁶, N. Theodoropoulos⁷, J. Schaenman⁸
¹Yale University School of Medicine, New Haven, CT, ²University of CO, Aurora, CO, ³Stanford, Palo Alto, CA, ⁴UCSD, San Diego, CA, ⁵Westchester Med Ctr, Westchester, NY, ⁶Mount Sinai SOM, New York, NY, ⁷Univ of MA, Worcester, MA, ⁸UCLA, Los Angeles, CA
*Purpose: Frailty is a multi-dimensional characterization of decreased reserve and diminished response to stressors in older adults. Frailty at the time of transplant has been…
2022 American Transplant Congress
Financial Impact of Adult Kidney Transplant MS-DRGs 650, 651 and 652 in U.S. Transplant Hospitals
E. Zavala¹, J. Rogers², H. Buschmann¹, S. Rath¹, S. Karp¹
¹VUMC, Nashville, TN, ²Transplant Management Group, San Diego, CA
*Purpose: The Medicare Hospital Inpatient Prospective Payment System (IPPS) permits each inpatient admission to be categorized into a diagnosis-related group (DRG). DRGs can be further…
2022 American Transplant Congress
Bone Effect and Safety of One Year Denosumab Therapy in a Cohort of Renal Transplanted Patients: An Observational Monocentric Study
C. Alfieri, M. Gandolfo, D. Cresseri, M. Campise, A. Regalia, P. Messa, G. Castellano
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Milano, Milano, Italy
*Purpose: In our observational monocentric study, we evaluated the effects on femoral and lumbar bone mineral density (BMD) and on MM parameters, and the safety…
2022 American Transplant Congress
Causal Factors and Clinical Impact of Urinary Tract Infections in Renal Transplanted Patients: An Observational Retrospective Study
C. Alfieri, F. Tripodi, D. Cresseri, M. Gandolfo, M. Campise, A. Regalia, P. Messa, G. Castellano
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Milano, Milan, Italy
*Purpose: This study aims to examine the etiology of urinary tract infections (UTIs) in a cohort of KTxps, trying to identify their potential predisposing factors…
2022 American Transplant Congress
Comparison of CT Volumetry versus Nuclear Renography for Predicting Remaining Kidney Function After Uninephrectomy in Living Kidney Donors
S. Eum¹, H. Lee¹, E. Ko¹, H. Cho², H. Yoon³, S. Shin³, C. Yang¹, B. Chung¹
¹Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ²Department of Urology, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ³Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's Hospital, Incheon, Korea, Republic of
*Purpose: Computed tomography (CT) and nuclear renography are used to determine kidney procurement strategy in living kidney donors (LKDs). The present study investigated which modality…
2022 American Transplant Congress
Discovery of Risk Factor Control Targets Using Machine Learning and Network Analysis for One-Year Renal Allograft Dysfunction
Y. Lee¹, M. Hong², J. Kong³, O. Kwon⁴, C. Jung⁵, J. Yang⁶, M. Kim⁷, H. Han⁸, S. Nam⁹
¹Division of Nephrology, Department of Internal medicine, CHA Bundang Medical Center, Seongnam, Korea, Republic of, ²Department of Biomedical Informatics,, CHA University School of Medicine, Seongnam, Korea, Republic of, ³Department of Nephrology,, BHS Hanseo Hospital, Pusan, Korea, Republic of, ⁴Department of Surgery, College of Medicine, Han Yang University, Seoul, Korea, Republic of, ⁵Department of Surgery, Korea University Anam Hospital, Seoul, Korea, Republic of, ⁶Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁷Department of Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁸Department of Biomedical Informatics, CHA University School of Medicine, CHA University, Seongnam, Korea, Republic of, ⁹Department of Ophthalmology, CHA Bundang Medical Center, Seongnam, Korea, Republic of
*Purpose: Early identification of graft loss risk and timely therapeutic intervention are crucial for preventing late renal allograft failure and improving long-term graft function. This…
2022 American Transplant Congress
Impact of the Covid-19 Pandemic on Longitudinal Molecular Surveillance in the KOAR Registry
T. Alhamad¹, A. Malone¹, D. Mandelbrot², P. M. Anand³, H. M. Wadei⁴, G. Shekhtman⁵, N. Agrawal⁵, K. Pinney⁵, K. Qu⁵, A. Desai⁶
¹Washington University, St. Louis, MO, ²University of Wisconsin, Madison, WI, ³Medical University of South Carolina, Charleston, SC, ⁴Mayo Clinic Jacksonville, Jacksonville, FL, ⁵CareDx, Brisbane, CA, ⁶Loyola University Medical Center, Maywood, IL
*Purpose: The SARS-CoV2 pandemic increased the complexity of delivering routine clinical care and laboratory services for immunosuppressed kidney transplant (KTx) recipients. We evaluated how the…