Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Impact of the Covid-19 Pandemic on Longitudinal Molecular Surveillance in the KOAR Registry
T. Alhamad¹, A. Malone¹, D. Mandelbrot², P. M. Anand³, H. M. Wadei⁴, G. Shekhtman⁵, N. Agrawal⁵, K. Pinney⁵, K. Qu⁵, A. Desai⁶
¹Washington University, St. Louis, MO, ²University of Wisconsin, Madison, WI, ³Medical University of South Carolina, Charleston, SC, ⁴Mayo Clinic Jacksonville, Jacksonville, FL, ⁵CareDx, Brisbane, CA, ⁶Loyola University Medical Center, Maywood, IL
*Purpose: The SARS-CoV2 pandemic increased the complexity of delivering routine clinical care and laboratory services for immunosuppressed kidney transplant (KTx) recipients. We evaluated how the…
2022 American Transplant Congress
The Successful Use of De Novo Belatacept with Reduced Dose Tacrolimus to Mitigate the Risks of Delayed Graft Function in Kidney Transplantation
E. Siskind¹, J. Splinter¹, C. Taing¹, A. Adekile², S. Njim¹, S. Shah¹, R. Plews³, D. Conti⁴, S. Patel²
¹Center for Transplantation, University Medical Center of Southern Nevada, Las Vegas, NV, ²University Medical Center of Southern Nevada, Las Vegas, NV, ³Center for Transplantation, Albany Medical Center, Albany, NY, ⁴Albany Medical Center, Albany, NY
*Purpose: The new kidney allocation system has caused increased organ travel times and therefore increased cold ischemia time. Furthermore, the change in the priority to…
2022 American Transplant Congress
Randomized, Phase 4 Study Evaluating the Pharmacokinetics and Tolerability of the New Tacrolimus Tablet Formulation (Tacrobell Tab) in Kidney Transplant Recipients
A. Han¹, E. Cho¹, H. Y. Woo¹, C. Ara¹, H. Lee², Y. Kim³, Y. Park⁴, J. Oh⁴, S. Min¹, J. Ha¹
¹Department of Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Nephrology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Clnical Pharmacology, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Previous twice-a-day tacrolimus formulations available were capsular and of limited dose formulations (0.5mg, 1mg). Recently a new tablet formulation of tacrolimus with more diverse…
2022 American Transplant Congress
Donor/Recipient Variabilities and Dd-cfdna Level
I. Gani¹, L. Mulloy¹, R. Mallavarapu¹, M. Saeed¹, R. Kapoor², A. Mirza¹
¹Augusta University Medical Center, Augusta, GA, ²Southwest Kidney Institute, Phoenix, AZ
*Purpose: Donor-derived cell-free DNA such as AlloSure (CareDx) is used as a non-invasive biomarker for allograft rejection and allograft injury as increased dd-cfDNA is observed…
2022 American Transplant Congress
Stem Cell Donor-Derived CPRA Better Reflects Sensitization Than Current CPRA
K. Lindblad¹, C. Murphey², P. Lalli³, J. Lunz⁴, L. Gragert⁵
¹UNOS, Richmnd, VA, ²Southwest Immunodiagnostics, Inc., San Antonio, TX, ³Carolinas Medical Center, Charlotte, NC, ⁴LifeLink Foundation Transplant Immunology Lab, Tampa, FL, ⁵Tulane University School of Medicine, New Orleans, LA
*Purpose: The OPTN Histocompatibility Committee proposes replacing the current calculated panel reactive antibody (CPRA), based on HLA haplotype frequencies from ~14,000 deceased kidney donors, with…
2022 American Transplant Congress
Impact of Recipient Obesity on Kidney Transplantation Outcome: A Retrospective Cohort Study with a Matched Comparison
A. Buemi
Surgery, Cliniques Universitaires Saint Luc, Bruxelles, Belgium
*Purpose: The aim of this study was to evaluate the effect of recipient obesity on posttransplant complications and patient and graft survival.*Methods: A single-institution, retrospective…
2022 American Transplant Congress
The Effect of Baseline Blood Pressure on Early Graft Function in Deceased Donor Kidney Transplantation
B. Jun Bae¹, C. Oh¹, H. Ahn²
¹Department of surgery, Ajou University Medical School, Suwon, Korea, Republic of, ²Department of Anesthesiology and Pain medicine, Ajou University Medical School, Suwon, Korea, Republic of
*Purpose: The adequate perfusion pressure to the graft is essential for proper graft function in kidney transplantation, especially in deceased donor kidney transplantation. Therefore, the…
2022 American Transplant Congress
Ultrasound Assessing Donor Kidney Quality in Deceased Donor Kidney Transplantation
S. Yun¹, K. Lee¹, S. Park², J. Park¹
¹Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Radiology and Center for Imaging Science, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: We evaluated the role of functional kidney volume using donor kidney ultrasound (US) alone or in combination with other donor factors and parameters appropriate…
2022 American Transplant Congress
Deceased Donor Kidney Transplantation from Donors with Acute Kidney Injury: Realities and Costs
S. Iskhagi¹, R. Shahbazov¹, A. Ball¹, S. Loerzel¹, E. Shaban², B. Gallay², R. Hod Dvorai³, J. Leggat², M. Hanlon¹, R. Saidi¹
¹Department of Surgery, Division of Transplantation, SUNY Upstate Medical University, Syracuse, NY, ²Department of Medicine, Division of Nephrology, SUNY Upstate Medical University, Syracuse, NY, ³Department of Pathology and Laboratory Medicine, SUNY Upstate Medical University, Syracuse, NY
*Purpose: The use of kidneys from deceased donors with acute kidney injury (AKI) is one of the options to expand donor pool. Several studied have…
2022 American Transplant Congress
Autophagy is an Important Factor in the Development of Fibrosis Following Renal Injury; Implications for Post-Transplant IFTA
R. Lopez-Soler¹, X. Ding², Q. Zang³
¹Tansplant, Surgery, Edward Hines VA Medical Center, Hines, IL, ²Pathology, Loyola University Medical Center, Maywood, IL, ³Surgery, Loyola University Medical Center, Maywood, IL
*Purpose: Interstitial Fibrosis and Tubular Atrophy (IFTA) is the most common cause of long-term graft failure following renal transplant. There is currently no effective therapy.…