2019 American Transplant Congress
Monitoring Circulating T Follicular Helper Cells Polarization, Activation and Function Distinguishes Asymptomatic Donor-Specific Anti-HLA Antibody Positive Kidney Transplant Recipients from Those Undergoing Antibody-Mediated Rejection
*Purpose: Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx).…2019 American Transplant Congress
Association between a Chronic Kidney Disease Treatment Education Class and Receipt of a Kidney Transplantation in the Southeastern U.S. Population
1Kaiser Permanente, Atlanta, GA, 2Emory University, Atlanta, GA
*Purpose: Predialysis education is associated with improved patient survival and improved access to kidney transplantation (KT), however many of the findings are based on a…2019 American Transplant Congress
IgG Glycosylation Causes Podocyte Injury in Transplant Glomerulopathy through Calcium Calmodulin Kinase IV
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
*Purpose: Transplant glomerulopathy(TG) is a major cause of late allograft loss. Increase in urine podocin/creatinine ratio in TG signifies acceleration of podocyte detachment from glomerular…2019 American Transplant Congress
Urinary Exosomal microRNA as a Non-Invasive Biomarker for the Diagnosis of Acute Rejection in Kidney Transplant Recipients
*Purpose: Acute rejection (AR) is the main obstacle to the graft survival after kidney transplantation. Urinary exosome is a promising source of biomarker for various…2019 American Transplant Congress
NK Cell Quantification by Paraffin Immunohistochemistry is Not Predictive of Graft Outcome in 1-Year Surveillance Biopsies
1Pathology, Michigan Medicine, Ann Arbor, MI, 2Nephrology, Michigan Medicine, Ann Arbor, MI
*Purpose: Molecular and animal studies have identified NK cells as important mediators and markers of antibody mediated rejection. Using three color immunohistochemistry for CD16, T-bet,…2019 American Transplant Congress
Increased Number of Intragraft FoxP3+ T Cells is Strongly Correlated with Decreased Graft Survival in Chronic Active Antibody Mediated Rejection
1Erasmus MC, Rotterdam, Netherlands, 2Amsterdam UMC, Amsterdam, Netherlands
*Purpose: Chronic-active antibody-mediated rejection (c-aABMR) is the most important cause of late renal allograft failure. However, renal inflammation and rate of loss of renal allograft…2019 American Transplant Congress
Estimated vs. Actual Graft Failure and Patient Survival after Kidney Transplantation
*Purpose: The purpose of this study was to examine the difference between the estimated and actual values of graft survival and patient survival in kidney…2019 American Transplant Congress
Evaluation of Envarsus XR in African American Kidney Transplant Recipients
1Pharmacy, Rush University Medical Center, Chicago, IL, 2Rush University Medical Center, Chicago, IL
*Purpose: This study is being conducted to evaluate the clinical impact of the utilization of tacrolimus LCP (TAC-LCP) compared to tacrolimus immediate release (TAC-IR) in…2019 American Transplant Congress
Risk Factors for Initial Sub- and Supra-Therapeutic Tacrolimus Trough Levels in Renal Transplant Recipients
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Sub-therapeutic tacrolimus trough levels have been associated with increased risk of rejection in renal transplant recipients and supra-therapeutic levels with infectious risks and drug…2019 American Transplant Congress
Inhibition of TLR4 Mediated Programmed Necrosis Does Not Improve Graft Function and Histology in a Murine Kidney Transplant Model
*Purpose: Human Delayed Graft Function (DGF) is associated with upregulation of basolateral tubular TLR4 but whether TLR4 causes DGF is unknown. TLR4 has been shown…
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