Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Economic Impact of Donor Hepatitis C Kidney Transplantation: A Medicare Cost Analysis
K. Lentine¹, M. Schnitzler², T. Alhamad³, H. Xiao², H. Randall², J. Wellen², B. Kasiske⁴, G. Hess⁵, D. Axelrod⁶
¹Saint Louis University Medical Center, St. Louis, MO, ²Saint Louis Univ, St. Louis, MO, ³Washington Univ, St. Louis, MO, ⁴SRTR, Minneapolis, MN, ⁵Univ of Pennsylvania, Philadelphia, PA, ⁶Univ of Iowa, Iowa City, IA
*Purpose: In the era of highly effective direct-acting antiviral agents (DAAs), kidney transplant (KT) from Hepatitis C virus (HCV)-positive donors is increasingly considered as an…
2019 American Transplant Congress
Kidney Paired Donation Transplant Outcomes: Experiences from the First Ten Years of the National Kidney Registry
D. B. Leeser¹, A. G. Thomas², A. A. Shaffer², J. Veale³, A. B. Massie², M. Cooper⁴, S. Kapur⁵, S. Kapur⁵, S. Kapur⁵, N. Turgeon⁶, D. Segev², A. Waterman³, S. Flechner⁷
¹East Carolina Univ Sch of Med, Greenville, NC, ²Johns Hopkins, Baltimore, MD, ³UCLA, Los Angeles, CA, ⁴Georgetown, Washington, DC, ⁵Weill Cornell Medical School, New York, NY, ⁶Emory, Atlanta, GA, ⁷Cleveland Clinic, Cleveland, OH
*Purpose: In the United States (US), kidney paired donation (KPD) networks have facilitated an increasing proportion of KTs annually, but longer-term transplant outcomes and differences…
2019 American Transplant Congress
Care of International Living Kidney Donor Candidates in the U.S.: A Survey of Contemporary Experience, Practice & Challenges
K. Lentine¹, M. Henderson², S. Rasmussen², E. Shukhman³, J. Hunt⁴, F. Al Ammary², V. Kumar⁵, D. Lapointe-Rudow⁴, H. Schaefer⁶, M. Cooper⁷, R. Hays⁸, M. Dunbar-Forrest⁹, A. Nishio-Lucar¹⁰, D. Mandelbrot⁸
¹Saint Louis Univ, Saint Louis, MO, ²Johns Hopkins, Baltimore, MD, ³Cedars Sinai, Los Angeles, CA, ⁴Mount Sinai, New York, NY, ⁵Univ Alabama, Birmingham, AL, ⁶Vanderbilt, Nashville, TN, ⁷Georgetown, Washington, DC, ⁸Univ Wisconsin, Madison, WI, ⁹UCLA, Los Angeles, CA, ¹⁰Univ Virginia, Charlottesville, VA
*Purpose: The evaluation and care of non-U.S. citizen, non-U.S. residents who wish to come to the U.S. to serve as living kidney donors (LKD) can…
2019 American Transplant Congress
Organ Resilience Contributes to Different Impact of Delayed Graft Function (DGF) on Graft Survival in Kidneys Donated by Brain Death (DBD) and Circulatory Death Donors (DCD)
M. J. de Kok, A. F. Schaapherder, L. G. Wijermars, D. K. de Vries, J. L. Lindeman
Transplantation Center, LUMC, Leiden, Netherlands
*Purpose: Despite a tripled higher incidence of DGF in DCD kidney grafts compared to DBD kidney grafts, large studies show equivalent long-term graft survival with…
2019 American Transplant Congress
Integrative Analysis of Immune Repertoire and Gene Expression from RNA-seq in Kidney Organ Transplants
S. Pineda¹, A. Ravoor², O. Bestard³, M. Sarwal¹, M. Sirota²
¹Department of Surgery, UCSF, San Francisco, CA, ²BCHSI, UCSF, San Francisco, CA, ³Department of Surgery, 3Bellvitge University Hospital, Barcelona, Spain
*Purpose: The main problem with kidney transplantation is the possibility of rejection, which is classified as either antibody-mediated rejection (AMR) or T-cell-mediated rejection (TCMR) depending…
2019 American Transplant Congress
Randomized Controlled Trial Of Spironolactone Effect In Kidney Transplant Recipients Of Living Donors
N. A. Bobadilla¹, L. E. Morales-Buenrostro¹, J. A. Ortega-Trejo¹, R. Perez-Villalva¹, L. Marino¹, Y. González-Bobadilla¹, H. Juarez¹, F. Zamora-Mejía¹, N. Gonzalez¹, R. Espinoza², J. Barrera-Chimal³
¹Nephrology, INCMNSZ, Mexico City, Mexico, ²Nephrology, Centro Médico Nacional Siglo XXI, Mexico City, Mexico, ³Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico
*Purpose: Mineralocorticoid receptor antagonism prevents acute kidney injury induced by ischemia/reperfusion in rodent and pig preclinical models. In a pilot study, we showed that spironolactone…
2019 American Transplant Congress
Pre-Transplant Donor-Specific IFN-γ ELISPOT as a Predictor of Allograft Rejection: A Diagnostic Test Accuracy Meta-Analysis
S. Farouk¹, I. Gandolfini², N. Montero³, E. Crespo⁴, M. Jarque⁴, M. Meneghini⁴, U. Maggiore², O. Bestard³, P. Cravedi¹
¹Medicine, Division of Nephrology, Icahn School of Medicine at Mt. Sinai, New York, NY, ²Centro Trapianti Rene-Pancreas, Azienda Ospedaliera-Universitaria di Parma, Parma, Italy, ³Nephrology, Bellvitge University Hospital, Barcelona, Spain, ⁴Experimental Nephrology Laboratory. IDIBELL, Barcelona, Spain
*Purpose: Pre-transplant interferon-γ (IFN-γ) enzyme-linked immunospot (IFN- γ ELISPOT) has been proposed as a tool to quantify alloreactivity of memory T cells and estimate the…
2019 American Transplant Congress
Donor-Derived Cell-Free DNA is Associated Specifically with Antibody Mediated Injury in Patients with Renal Allograft Dysfunction
B. Obrisca¹, C. Blosser², I. De Castro², C. Johnson², B. Sorohan¹, L. Sibulesky², R. Bakthavatsalam², G. Ismail¹, N. Leca²
¹Fundeni Clinical Institute, Bucharest, Romania, ²University of Washington, Seattle, WA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been proposed as a noninvasive biomarker to differentiate rejection from other types of injury in renal allografts.*Methods: We analyzed…
2019 American Transplant Congress
Management of Inactive Candidates on the Kidney Transplant Waitlist: Results from a National Survey
J. Hiller, J. Chen, K. Covarrubias, K. Jackson, J. Long, S. DiBrito, D. Segev, J. Garonzik Wang
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: As the inactive deceased donor kidney transplant (DDKT) waitlist pool continues to grow, management of these patients has become an increasingly complex administrative undertaking.…
2019 American Transplant Congress
Dosing and Exposure over 2 Years with LCP-Tacrolimus (LCPT) vs. Immediate-Release Tacrolimus (IR-Tac) in De Novo Kidney Transplantation
K. Budde¹, S. Bunnapradist², S. Patel³, D. Stevens³, U. Meier-Kriesche³, B. Suwelack⁴
¹Charité University Medicine Berlin, Berlin, Germany, ²UCLA Medical Center, Los Angeles, CA, ³Veloxis Pharmaceuticals Inc, Cary, NC, ⁴University Hospital of Münster, Münster, Germany
*Purpose: A prospective study demonstrated safe and efficacious use of LCPT in de novo kidney transplantation. This study aims to evaluate tacrolimus trough levels and…