2020 American Transplant Congress
Beta Cell Replacement Therapy in Nonuremic Patients with Brittle T1DM Allows for Durable Long Term Insulin Independence Halting Progression of Secondary Diabetic Complications
*Purpose: Beta cell replacement therapy in form of pancreas or islet transplantation is the only effective treatment for patients suffering from hypoglycemic unawareness despite intensive…2020 American Transplant Congress
The Mechanism How the Transplanted Islets Engraft Into White Adipose Tissue
Department of Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka, Japan
*Purpose: While islet transplantation is recognized as a promising therapeutic option for severe diabetes mellitus (DM), especially type 1 DM, it still faces to various…2020 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation in Diabetic and Prediabetic Patients with Intractable Chronic Pancreatitis
*Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for non-diabetic patients with intractable chronic pancreatitis. The outcome and potential benefits for…2020 American Transplant Congress
High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome
Baylor University Medical Ctr, Dallas, TX
*Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…2020 American Transplant Congress
Long-Term Islet Allo- and Xenograft Survival is Promoted by Immunoglobulin M Immunotherapy
Department of Surgery, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if islet allo- and xenotransplant rejection is mitigated by IgM immunotherapy.*Methods: a) New onset diabetic NOD mice (n=14) were treated with IgM…2020 American Transplant Congress
Long-Term Outcomes with Islet Alone and Islet-after-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium
*Purpose: Phase 3 studies of islet transplant alone (ITA; n=48) and islet-after-kidney (IAK; n=24) transplantation in type 1 diabetes complicated by severe hypoglycemic events (SHE)…2020 American Transplant Congress
Pancreas Transplant in Chronic Kidney Disease for Type 1 Diabetic Patients
*Purpose: Although both pancreas transplantation alone (PTA) and islet cell transplantation (ICT) have been associated with peri-operative declines in eGFR, the magnitude of decline is…2020 American Transplant Congress
Evaluation of US Doppler Examination of Portal Flow Dynamics in Patients with Total Pancreatectomy and Autologous Islet Cell Transplant
University of North Carolina, Chapel Hill, NC
*Purpose: The aim of this study is to evaluate US doppler flow dynamics following total pancreatectomy and autologous islet cell transplant (TPAIT) and establish any…2020 American Transplant Congress
TPIAT Outcomes in Diabetic and Non-Diabetic Patients with Chronic Pancreatitis
Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy with islet auto-transplantation (TPIAT) is becoming the standard of care for patients with severe chronic pancreatitis (CP). However, it is necessary to…2020 American Transplant Congress
Plasma Cells Are Not Necessary for Regulatory B Cells and Preventing Their Differentiation Markedly Prolongs Allograft Survival
Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Plasma Cells (PCs) are the primary source of circulating antibodies. PCs were reported to be the major source of B-cell lineage IL-10, and absence…
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