Articles tagged "Islets"

2016 American Transplant Congress
Characterization of Human Islet Transplant Specific Exosomes in a Xenoislet Transplantation Model.
P. Vallabhajosyula, L. Korutla, M. Yu, S. Rostami, C.-X. Yuan, C. Liu, V. Korutla, S. Reddy, A. Habertheuer, A. Naji.
Department of Surgery, University of Pennsylvania, Philadelphia, PA.
Background: There is a critical need for biomarker platforms for monitoring transplant rejection. We propose that transplant tissues release donor specific exosomes into recipient blood/…
2016 American Transplant Congress
NFκB Inhibitor Withaferin A Blocks IBMIR In Vitro: miRNA 375 Analysis.
M. Kanak,¹ M. Takita,² G. Yoshimatsu,² M. Lawrence,² M. Levy,¹ B. Naziruddin.³
¹Surgery, Virginia Commonwealth University, Richmond, VA; ²Islet Tranpsplant Lab, Baylor Research Institute, Dallas, TX; ³Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX.
Background: Instant Blood Mediated Inflammatory Reaction (IBMIR) has been shown to severely affect islet engraftment. We previously reported that Withaferin A (WA) can protect islets…
2016 American Transplant Congress
CXCL12 as Innovative Immune Isolating Chemokine for Microencapsulated Allo and Xeno-Transplantation in NHPs.
M. Sremac,¹ A. Saraya,¹ O. Clemente,¹ M. Penson,¹ S. Chavan,³ N. Chronos,³ C. Schuetz,² J. Lei,² J. Markmann,² T. Brauns,¹ M. Poznansky.¹
¹Infectious Disease/VIC, Massachusetts General Hospital, Boston, MA; ²Division of Transplantation, Massachusetts General Hospital, Boston, MA; ³VICapsys, Inc, Athens, GA.
Introduction The purpose of this study is to determine whether a clinical-grade alginate-microencapsulant incorporating CXCL12, can protect and sustain the function of allo and/or adult…
2016 American Transplant Congress
A Novel Microfluidic Device for Purification of Pancreatic Islet Preparations.
W. Varhue,¹ L. Langman,² D. Bowers,³ S. Peirce-Cottler,³ N. Swami,¹ K. Brayman.²
¹Electrical and Computer Engineering, University of Virginia, Charlottesville, VA; ²Surgery, University of Virginia, Charlottesville, VA; ³Biomedical Engineering, University of Virginia, Charlottesville, VA.
Purpose: Demonstrate that novel continuous flow microfluidic designs can be utilized to remove contaminating acinar tissue and sort the purified islets, based on size and…
2016 American Transplant Congress
Utilization of Plasmapheresis and High Dose of Immunoglobulins in the Treatment of the High Level of De Novo Donor Specific Antibodies for the Successful Islet Allotransplantation.
J. Solomina,¹ Z. Tekin,¹ S. Matosz,¹ K. Golab,¹ C. Thomas,² J. Golebiewska,³ S. Ramachandran,¹ L. Schenck,¹ W. Chon,¹ M. Tibudan,¹ N. Marek-Trzonkowska,⁴ J. Millis,¹ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Medicine, University of Chicago, Chicago, IL; ³Internal Medicine, Medical University of Gdansk, Gdansk, Poland; ⁴Family Medicine, Medical University of Gdansk, Gdansk, Poland.
Background.Development of donor specific antibodies (DSA) after islet transplantation has been a poor prognostic factor for graft survival, while no intervention is implemented. Here, we…
2016 American Transplant Congress
Citrate-Based Thermoresponsive Hydrogel as a Versatile Platform for Extrahepatic Islet Transplantation.
Y. Zhu,¹ X. Zhang,² A. Guillermo,¹ X. Luo.²
¹McCormick School of Engineering, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Introduction: Islets transplantation in the liver often results in limited islets survival presumably due to abnormal blood flow dynamics and acute inflammatory response. The objective…
2016 American Transplant Congress
Low Risk of Cytomegalovirus (CMV) Transmission in Clinical Islet Transplantation.
D. Kabbani,¹ K. Cheung,² P. Senior,² C. Cervera,¹ K. Doucette,¹ J. Preiksaitis.¹
¹Infectious Diseases, University of Alberta, Edmonton, AB, Canada; ²Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada.
Background:In solid organ transplantation (SOT), CMV is commonly transmitted from seropositive organ donors (D+) to seronegative recipients (R-), despite the use of antiviral prophylaxis. The…
2016 American Transplant Congress
A Novel, Non-Viral mRNA Delivery System for Targeted Protein Translation in Human Islets.
J. Oberholzer,^1,2 D. Gutierrez,^1,2 E. Marchese,¹ M. Nourmohammadzadeh,^1,2 Y. Wang.^1,2
¹Department of Surgery, University of Illinois at Chicago, Chicago, IL; ²Department of Bioengineering, University of Illinois at Chicago, Chicago, IL.
Background: We propose using an innovative technology that utilizes gold nanoparticles (AuNPs) as a non-viral method of delivery. Our laboratory was one of the first…
2016 American Transplant Congress
MicroRNA-375 and -200c Are a Set of Novel Biomarkers That Can Predict Islet Autotransplantation Outcome.
G. Yoshimatsu,¹ M. Kanak,² M. Takita,¹ S. Prathab Balaji,¹ C. Chang,¹ M. Lawrence,¹ M. Levy,² N. Onaca,³ P. Kim,³ B. Naziruddin.³
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractive chronic pancreatitis to relieve pain and retain endocrine function. Patient selection is…
2016 American Transplant Congress
A Non-Hematopoietic Erythropoietin Analogue, ARA 290, Prolonged Allogeneic Pancreatic Islet Graft Survival in a Mouse Model.
M. Watanabe,¹ M. Yao,¹ D. Andersson,¹ M. Brines,² T. Lundgren,¹ M. Kumagai-Braesch.¹
¹Division of Transplantation Surgery, CLINTEC, Karolinska Institutet, Stockholm, Sweden; ²Araim Pharmaceuticals, Tarrytown, NY.
Purpose. Erythropoietin exerts anti-inflammatory, anti-apoptotic and cyto-protective effects in addition to its hematopoietic property. We have recently shown that ARA 290, a non-hematopoietic erythropoietin analogue,…