Articles tagged "Islets"

2022 American Transplant Congress
The Application of Activated Stem Cells from Human Exfoliated Deciduous Teeth (SHED) in Islet Transplantation for Novel Immunosuppressive Therapy
K. Ishiyama¹, M. Kato², S. Tsunekawa², Y. Miwa¹, K. Iwasaki¹, H. Kamiya², T. Kobayashi¹
¹Division of Kidney Transplantation, Department of Surgery, Aichi Medical University, Nagakute, Japan, ²Division of Diabetes, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan
*Purpose: While various attempts have been made to improve the efficiency of islet transplantation, we have been working on the analysis of the mechanism of…
2022 American Transplant Congress
Biological Functions of Circulating miRNAs in Patients with Chronic Pancreatitis Undergoing Total Pancreatectomy with Islet Autotransplantation
S. Vasu¹, C. Darden², Y. Liu³, M. Lawrence⁴, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX, ³-Baylor University Medical Center, Dallas, TX, ⁴Baylor University Medical Center, Dallas, TX
*Purpose: Our previous reports showed that in patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after…
2022 American Transplant Congress
Tacrolimus Induces Dedifferentiation of Pancreatic Beta Cells by Inhibition of Calcineurin/NFATc2 and Islet Cell Differentiation Genes
C. M. Darden¹, S. Vasu², J. Mattke³, Y. Liu², B. Naziruddin⁴, M. C. Lawrence²
¹Baylor University, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University, Waco, TX, ⁴Baylor University Medical Ctr, Dallas, TX
*Purpose: Tacrolimus (FK506) is a potent immunosuppressant widely used for solid organ transplantation to prevent lymphokine gene expression by inhibiting calcineurin (CN) and its downstream…
2022 American Transplant Congress
Evidence for Improved Quality of Life Among Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation Using EORTC QLQ-C30 and QLQ-PAN 26
M. Coluzzi, B. Naziruddin, G. Saracino, G. Testa, E. Beecherl, N. Onaca
Baylor University Medical Center, Dallas, TX
*Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is the treatment of choice to preserve endocrine function, alleviate pain, reduce or eliminate chronic narcotic use and…
2022 American Transplant Congress
Pegylated Lacritin N-104 Promotes Mouse Islet Stabilization and Prevents Diabetes Progression in the Non-Obese Diabetic (NOD) Mouse Model
M. Ma¹, P. Chhabra¹, G. Laurie², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if PEGylated Lacritin N-104 (PEG N-104) prevents the progression of type 1 diabetes (T1D) in the NOD mouse.*Background: Lacritin is a multifunctional…
2022 American Transplant Congress
Generation Of Insulin Producing Cells From Pancreatic Tissue With Long Standing Type 1 Diabetes
Y. Garciafigueroa, J. B. Pollett, N. L. Thai, R. Bottino
Imagine Pharma, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells), are a novel cell population from isolated human islets obtained using a simple culture protocol that can generate cells…
2022 American Transplant Congress
Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture
A. Asthana¹, D. Chaimov¹, R. Tamburrini², S. J. Walker³, G. Orlando¹
¹Wake Forest Baptist Medical Center, Winston-Salem, NC, ²University of Wisconsin Hospital and Clinics, Madison, WI, ³Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
*Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
2022 American Transplant Congress
‘Adjuvant Conditioned’ Myeloid Derived Suppressor Cells Prolong Islets Graft Survival Through IL-10 Production
J. Ge¹, L. Ott¹, A. Das¹, J. Markmann², A. Cuenca¹
¹Department of Surgery, Boston Children's Hospital, Boston, MA, ²Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Advances in immunosuppression have been relatively stagnant over the last 2 decades and transplant patients continue to experience morbidity associated with immunosuppression regimens. Through…
2022 American Transplant Congress
Bionic Pancreas – The First Results of Functionality of 3D-Bioprinted Bionic Tissue Model Transplantation with Pancreatic Islets
M. Klak¹, M. Wszola¹, A. Berman¹, A. Filip¹, A. Kosowska², J. Olkowska-Truchanowicz², G. Tymicki¹, M. Rachalewski¹, T. Bryniarski¹, M. Kolodziejska¹, T. Dobrzanski³, D. Ujazdowska¹, J. Wejman⁴, I. Uhrynowska-Tyszkiewicz², A. Kaminski²
¹Foundation of Research and Science Development, Warsaw, Poland, ²Medical University of Warsaw, Warsaw, Poland, ³Polbionica Ltd., Warsaw, Poland, ⁴Center for Pathomorphological Diagnostics Ltd, Warsaw, Poland
*Purpose: Tissue engineering is currently on advanced stage of development which gives a possibilities for novel strategy of personal treatment of type 1 diabetes. AIM:…
2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
M. Ma¹, P. Chhabra¹, C. Roosa², D. R. Griffin², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…

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