2022 American Transplant Congress
FasL-Presenting PEG Microgels Supports Sustained Graft Survival in Nonhuman Primates in the Absence of Continuous Immunosuppression
*Purpose: Broad application of allogeneic islets for T1D treatment is curtailed by the use of chronic immunosuppression to control rejection. Teff cells are the major…2022 American Transplant Congress
Engineered Adaptable Human Endothelial Cells Enable Durable Engraftment of Subcutaneously Transplanted Islets
Weill Cornell Medical College, New York, NY
*Purpose: The current clinical practice of islet transplantation into the portal vein is suboptimal, with reduced vascularization limiting successful engraftment and the inability for monitoring…2022 American Transplant Congress
Pancreatic Islets Engineered with Thrombomodulin Show Enhanced Engraftment in an Intraportal Transplantation Model by Mitigating Instant Blood-Mediated Inflammatory Reactions
*Purpose: IBMIR is a major culprit of early islet loss post-transplant. Thrombomodulin (TM) is an anti-coagulant and cofactor of activated Protein C (APC) that perpetuates…2022 American Transplant Congress
Smartphone-Microfluidic Fluorescence Imaging System for Studying Islet Physiology
University of Virginia, Charlottesville, VA
*Purpose: The goal of this study is to develop an innovative smartphone-microfluidic fluorescence imaging (µSFI) system for multi-parameter islet function characterization, which could provide quantitative…2022 American Transplant Congress
Long-Term Insulin Independence Achieved by a Multimodal Approach to Beta-Cell Replacement in Patients with Type I Diabetes
*Purpose: Long-term insulin independence in beta-cell replacement, via islet or pancreas transplant, remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta cells…2022 American Transplant Congress
Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Islet Transplantation
University of Virginia, Charlottesvle, VA
*Purpose: Classical microencapsulation technologies for islet transplantation faces two major challenges associated with individual microcapsules. First, due to long-term gravity individual microcapsules often aggregate to…2022 American Transplant Congress
Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression
1Baylor University, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX
*Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…2022 American Transplant Congress
Characterization of Activated Islet Proliferating Cells (AIPCs) During Maturation to Pseudo-Islets
Imagine Pharma, Pittsburgh, PA
*Purpose: We have previously described a novel population of cells developed from human islets called AIPCs (Activated Islet Proliferating Cells). AIPCs co-express CD133, glucagon and…2022 American Transplant Congress
Intra Portal Islet Auto Transplantation (IAT) Independently Improves Quality of Life in Patients After Total Pancreatectomy (TP) and IAT in Patients with Chronic Refractory Pancreatitis
University of Minnesota Medical School, Minneapolis, MN
*Purpose: TPIAT is utilized for intractable chronic-pancreatitis (CP).TP removes the source of pain and the addition of an islet auto transplant (IAT) minimizes the risk…2022 American Transplant Congress
Preclinical Evaluation of Functional Survival of Stem Cell Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestwon, MA
*Purpose: Human stem cell-derived islet-like cells (SC-islets) represent a sustainable source for beta-cell replacement to achieve a functional cure for type 1 diabetes. We previously…
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