ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Ischemia"

  • 2022 American Transplant Congress

    Donor Exercise Preconditioning Protects Murine Orthotopic Liver Grafts During Ischemia Reperfusion Injury

    H. O. Yazdani, C. Kaltenmeier, R. Nakano, R. L. Simmons, D. A. Geller, S. Tohme

    Surgery, University of Pittsburgh Medical Center, Pissburgh, PA

    *Purpose: Orthotopic liver transplantation (LTx) serves as the gold standard of care in patients with end-stage liver disease. However, a major obstacle to the immediate…
  • 2022 American Transplant Congress

    Donor Organ Utilization And Transplantation Outcomes In Donation After Circulatory Death Using Thoracoabdominal Normothermic Regional Perfusion

    M. Urban, S. Merani, N. W. Markin, A. Castleberry, J. Um

    University of Nebraska Medical Center, Omaha, NE

    *Purpose: Evidence suggests that in-situ reperfusion of abdominal organs with normothermic oxygenated blood in donation after circulatory death (DCD) provides superior post-transplantation outcomes in comparison…
  • 2022 American Transplant Congress

    Evolution of Donor-Derived Cell-Free DNA During the First Week After Surgery Predicts Renal Function Recovery After Kidney Transplantation

    D. Cucchiari1, E. Cuadrado1, E. Gonzalez1, J. Puig1, M. Ramirez-Bajo1, P. Ventura-Aguiar1, I. Revuelta2, B. Bayès1, F. Diekmann1

    1Hospital Clínic de Barcelona, Barcelona, Spain, 2Hospital Clinic de Barcelona, Barcelona, Spain

    *Purpose: Donor-derived cell-free DNA (ddcfDNA) is usually employed starting from the second week after kidney transplantation (KT), as its earlier increase can be due to…
  • 2021 American Transplant Congress

    Proxies of Ischemia Time Do Not Predict 1-Year Posttransplant Survival

    M. Skeans1, A. Wey1, E. Lease2, C. Lehr3, J. Alcorn4, R. Goff4, D. Stewart4, M. Valapour3

    1SRTR, Minneapolis, MN, 2Univ of Washington, Seattle, WA, 3Cleveland Clinic, Cleveland, OH, 4UNOS, Richmond, VA

    *Purpose: A barrier to broader distribution of donor organs is a concern that increased donor-to-recipient (DtR) distances could increase ischemia times and compromise posttransplant (PT)…
  • 2021 American Transplant Congress

    Glycogen Synthase Kinase 3 Beta Regulates Distinctive Macrophage Subsets in the Activation and Resolution of Liver Ischemia Reperfusion Injury

    H. Zhang1, M. Ni2, J. Zhang1, H. Wang2, R. Busuttil1, J. Kupiec-Weglinski1, Y. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Glycogen synthase kinase 3β (Gsk3β) differentially regulates pro- and anti-inflammatory programs in macrophages upon TLR stimulations. We have documented in a murine liver partial…
  • 2021 American Transplant Congress

    Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury

    V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Multiple clinical and pre-clinical studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome. We have previously reported that following…
  • 2021 American Transplant Congress

    Identification and Comprehensive Validation of Prognostic Genes After Ischemic and Reperfusion Injury Across Different Donor Types in Renal Transplantation

    D. Zhang, Y. Wang, Y. Wang, X. Hu

    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

    *Purpose: Ischemic and reperfusion injury (IRI) remains an inevitable and major challenge for renal transplant patients. The current study aims to obtain overall insights into…
  • 2021 American Transplant Congress

    Pathways and Factors That Confer Therapeutic Properties of Adipose Derived Regenerative Cells in Reducing Ischaemia Reperfusion Injury in Kidney Transplantation

    R. Lathan, P. Mark, M. Clancy, R. Touyz

    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

    *Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…
  • 2021 American Transplant Congress

    Early Hypertransaminasemia in Kidney Transplant Recipient: Influence of Donor Type and Clinical Significance

    E. Solà-Porta, M. Redondo-Pachón, S. Núñez-Delgado, C. Arias-Cabrales, M. Mir, A. Buxeda, C. Burballa, M. Crespo, J. Pascual, M. Pérez-Sáez

    Nephrology, Hospital del Mar, Barcelona, Spain

    *Purpose: The increase in transaminases after kidney transplant (KT) is frequent. Although the cause is unknown, it has been associated with factors such as immunosuppression,…
  • 2021 American Transplant Congress

    Microbial Signatures Promote Antibiotic-Mediated Alleviation of Peritransplant Liver Damage in Mouse Recipients

    K. J. Dery1, S. Kageyama1, H. Hirao1, H. Kojima1, K. Kadono1, T. Dong2, J. W. Kupiec-Weglinski1

    1The Dumont-UCLA Transplantation Center, Los Angeles, CA, 2Department of Medicine, Vatche & Tamar Manoukian Division of Digestive Diseases, UCLA, Los Angeles, CA

    *Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
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