2022 American Transplant Congress
CD38 Knockout Mice Demonstrate Decreased Neutrophil Infiltration Following Renal Ischemia Reperfusion Injury
1Ohio State University, Columbus, OH, 2The Ohio State University, Columbus, OH
*Purpose: Ischemia reperfusion injury (IRI) perpetuates inflammation and causes significant organ injury in solid organ transplantation. CD38 is a ectoenzyme widely expressed on lymphocytes with…2022 American Transplant Congress
Estimating the Effect of Increased Donor Heart Ischemic Time on Post-Transplant Survival Using Instrumental Variables
*Purpose: Isolate the impact of organ ischemic time on post-transplant survival using the recent change in heart allocation policy as a natural experiment.*Methods: We examined…2022 American Transplant Congress
Cost-Effectiveness of an Intra-Operative Renal Allograft Cooling Device
1University of California, San Francisco, San Francisco, CA, 2Stanford, Palo Alto, CA
*Purpose: Existing literature shows intra-operative cooling of a renal allograft during anastomosis reduces the incidence of delayed graft function in deceased donor kidney transplant recipients…2021 American Transplant Congress
P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…2021 American Transplant Congress
Augmented Responses of Donor Kidney Tubular Cells to TLR Signaling Correlate with Ameliorated Ischemia/reperfusion Injury and Long-term Allograft Protection
*Purpose: We have previously demonstrated that donor genetic background and kidney-intrinsic innate immunity were key determinants of delayed graft function in kidney transplantation. However, the…2021 American Transplant Congress
Ikaros-SIRT1 Signaling Axis Regulates Macrophage Polarization and Ischemia Reperfusion Injury in Mouse and Human Liver Transplantation
1The Dumont-UCLA Transplant Center, Los Angeles, CA, 2NIEHS, Durham, NC
*Purpose: Although Ikaros is a well-established transcriptional regulator of lymphopoiesis and differentiation of leukocyte lineage, its role in myeloid cells and ischemia reperfusion injury remain…2021 American Transplant Congress
Caspase-3 is a Predominant Regulator of Microvascular Dysfunction and Aki-ckd Transition Post Renal Ischemia-reperfusion Injury
CRCHUM, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an effector responsible for apoptosis execution, is activated within tubular epithelial…2021 American Transplant Congress
Superior Post-transplant Clinical Outcomes Using Portable Normothermic Perfusion and Assessment with the Organ Care System (ocs) Liver System: 1-year Outcomes of the Ocs Liver Protect Randomized Controlled Trial
*Purpose: The OCS Liver PROTECT Trial was the first U.S. randomized controlled trial for liver perfusion and was designed to evaluate the impact of portable…2021 American Transplant Congress
Tubastatin-a Mediated Protection from Liver Injury is Preserved in a Lymphocyte Deficient Model
1University of Pennsylvania, Philadelphia, PA, 2University of Illinois at Chicago, Chicago, IL
*Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…2021 American Transplant Congress
Role of Ferroptosis Inhibitors in Mitigating Ischemia-Reperfusion Injury in Marginal Livers Using a Novel Protect Model
Saint Louis University, Saint Louis, MO
*Purpose: The discard rate of deceased donor livers (DDL) remains high at nearly 9% and incudes livers that are steatotic, old in age, and from…
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