Articles tagged "Ischemia"

2018 American Transplant Congress
HO-1 Regulates SIRT1– Autophagy Pathway in Liver Transplantation: From Mouse-to-Human
K. Nakamura,¹ S. Kageyama,¹ S. Yue,¹ A. Aziz,¹ T. Ito,¹ D. Oncel,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Division of Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
Liver ischemia-reperfusion injury (IRI) represents a major risk factor for early graft dysfunction and a key obstacle to expanding the donor pool in orthotopic liver…
2018 American Transplant Congress
Hyperglycemia-Triggered ATF6-CHOP Pathway Exacerbates Liver Ischemia/Reperfusion Injury: Immunomodulation by Regulating β-Catenin Signaling
J. Rao,^1,2 C. Yang,¹ Y. Hu,¹ S. Yang,¹ Y. Xia,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,² L. Lu.^1,2
¹Department of Liver Surgery/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles.
Background & Aims: Hyperglycemia is a risk factor for hepatic ischemia/reperfusion injury (IRI) during liver transplantation or hepatectomy; however, the underlying mechanism remains unclear. Our…
2018 American Transplant Congress
The Role of Ex Vivo Normothermic Preservation in Minimizing Postreperfusion Syndrome in Liver Transplantation
A. Hassan, J. Cywinski, Q. Liu, D. Pezzati, D. Yang, L. Liu, G. Iuppa, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.
Transplant Surgery, Cleveland Clinic, Cleveland.
Background:Graft reperfusion holds a major challenge during liver transplantation. NMP may improve post-reperfusion hemodynamics, reduce vasopressor and blood product transfusion.Methods:15 patients with liver transplantation after…
2018 American Transplant Congress
Ischemia-Free Liver Transplantation for Fatty Liver Grafts in Human
W. Ju, S. Huang, Z. Guo, G. Chen, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
BACKGROUND&AIMS: Fatty liver diseases have led to a continuous increase of available donor livers containing fat. Fatty liver grafts were identified as an independent risk…
2018 American Transplant Congress
Early Blockade of Toll-Like Receptor 4 Reduces Ischemia-Reperfusion Injury and Improves Islet Transplantation Outcomes
C. Chang,¹ M. Lawrence,² R. Kane,¹ B. Naziruddin.³
¹Institute of Biomedical Studies, Baylor University, Waco; ²Baylor Scott & White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Purpose: Inflammatory damage to islets during isolation is a major hurdle for success in transplantation. We investigated the safety and therapeutic potential of pharmacological blockade…
2018 American Transplant Congress
PGE2/Beta-Catenin/XBP1 Signaling Controls Mesenchymal Stem Cell-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury
C. Li, S. Yue, L. Jiang, Q. Zhu, D. Farmer, R. Busuttil, J. Kupiec-Weglinski, B. Ke.
The Dumont-UCLA Transplant Center, Department of Surgery, Los Angeles, CA.
Background: Mesenchymal stem cells (MSCs) display profound immunomodulatory properties and tissue repairing capability under inflammatory conditions. However, it is unknown how MSCs may affect immunity…
2018 American Transplant Congress
Hyperglycemia-Triggered S1P/SIPR3signaling Exacerbates Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization
J. Rao,^1,2 Y. Hu,¹ C. Yang,¹ S. Yang,¹ F. Cheng,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,^1,2 L. Lu.^1,2
¹Department of Liver Surgery/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles.
Background and Aims: Hyperglycemia/Diabetes is an adverse risk factor for hepatic ischemia/reperfusion injury (IRI) during liver transplantation or hepatectomy; however, the underlying mechanism remains unclear.Sphingosine…
2018 American Transplant Congress
Evaluation of a Marine OXYgen Carrier (Hemo2Life®) for Organ Preservation: First Use in Kidney Transplantation in Humans
Y. Le Meur,¹ E. Morellon,² M. Essig,³ A. Thierry,⁴ M. Buchler,⁵ S. Drouin,⁶ C. Deruelle,¹ L. Badet,² F. Pesteil,³ P-.O. Delpech,⁴ J-.M. Boutin,⁵ B. Barrou.⁶
¹Transplantation, University Hospital, Brest, France; ²Hopital Edouard Herriot, Lyon, France; ³University Hospital, Limoges, France; ⁴University Hospital, Poitiers, France; ⁵University Hospital, Tours, France; ⁶La Pitié Salpetrière, Paris, France.
Preventing ischemia/reperfusion injuries (IRIs) is a major issue in organ transplantation. At present, grafts are preserved at 4[deg]C in preservation solution in order to reduce…
2018 American Transplant Congress
Ischemia Reperfusion Injury & Risk for Antibody Mediated Rejection (ABMR) in HLA Sensitized Patients Treated with C1 Esterase Inhibitor (C1INH)
A. Vo,¹ O. Aubert,² J. Choi,¹ N. Ammerman,¹ H. Edmund,¹ A. Peng,¹ R. Najjar,¹ S. Supreet,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; ²Paris Translational Research for Organ Transplantation, Necker Hospital, Paris, France.
Introduction: Ischemia reperfusion injury (IRI) contributes to delayed graft function (DGF). IRI/DGF in HLA-sensitized (HS) patients likely activates innate and memory injury pathways that may…
2018 American Transplant Congress
Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidneys from Donation after Circulatory Death: A Multi-Centre Randomised Controlled Trial
D. Summers,^1,2 L. Randle,¹ A-.M. O'Sullivan,³ R. Johnson,² D. Collett,² M. Attia,⁴ N. Ahmad,⁴ M. Clancy,⁵ M. Akyol,⁶ A. Tavakoli,⁷ N. Jamieson,³ A. Bradley,¹ C. Watson.¹
¹Cambridge University, Cambridge, United Kingdom; ²NHS Blood and Transplant, Bristol, United Kingdom; ³Cambridge University Hospitals, Cambridge, United Kingdom; ⁴Leeds Teaching Hospitals, Leeds, United Kingdom; ⁵Queen Elizabeth Hospital, Glasgow, United Kingdom; ⁶Edinburgh University, Edinburgh, United Kingdom; ⁷Manchester University Hospitals, Manchester, United Kingdom.
Introduction:Delayed graft function affects around half of all recipients of donation after circulatory death (DCD) kidneys in the UK and has a significant impact on…