2019 American Transplant Congress
Estrogen Mediated Protection in Renal Ischemia Reperfusion Injury (IRI) is Extrinsic to the Kidney
*Purpose: IRI causes morbidity in renal transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required so that strategies…2019 American Transplant Congress
Intra-Abdominal Hypertension in Simultaneous Pancreas-Kidney Transplantation
Nephrology and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
*Purpose: There have been several reports of raised intra-abdominal pressure (IAP) in solid organ transplantation, including life threatening abdominal compartment syndrome requiring decompressive laparotomy. In…2019 American Transplant Congress
Improved Transplant Outcomes in Ischemia-Free Liver Transplantation: A Report of the First 30 Cases
Organ Transplant Center, the First Affiliated Hospital of SYSU, Guangzhou, China
*Purpose: We developed a novel procedure called ischemia-free liver transplantation (IFLT) to bridge liver grafts from donors to recipients without cessation of blood supply. Herein,…2019 American Transplant Congress
Optimizing a Protocol for Extended Ex-Vivo Extremity Perfusion
*Purpose: Our objective is to demonstrate that Ex-Vivo Extremity Perfusion (EVEP) of a Vascularized Composite Allograft (VCA) is as effective, or superior, to standard cold…2019 American Transplant Congress
Graft TIM4 Deficiency Protects Liver from Ischemia Reperfusion Injury: From Mouse to Human
*Purpose: Liver ischemia-reperfusion injury (IRI) is a major risk factor for early graft dysfunction and rejection in orthotopic liver transplantation (OLT). We and others have…2019 American Transplant Congress
Ceria-Zirconia Nanoparticles as an Enhanced Antioxidant Attenuates Apoptosis of Human Kidney Proximal Tubular Epithelial Cells in Hypoxia
*Purpose: Ischemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of delayed graft function and graft rejection. Various mechanisms have been…2019 American Transplant Congress
Supercooling Preservation Prolonged Mouse Cardiac Graft Cold Ischemia Time
*Purpose: Supercooling preservation techniques store a donor organ below 0°C without freezing. This has great advantages in inhibiting metabolism and preserving the organ in comparison…2018 American Transplant Congress
DAP12 and Its Triggering Co-Receptor TREM2 Play Key Roles in Regulation of Mouse and Human Liver DC Function and Control of Liver Ischemia-Reperfusion Injury
Background: Liver interstitial dendritic cells (DCs) have been implicated in the control of liver ischemia/reperfusion injury (IRI) and in the induction of liver transplant tolerance.…2018 American Transplant Congress
HO-1 Regulates SIRT1– Autophagy Pathway in Liver Transplantation: From Mouse-to-Human
Liver ischemia-reperfusion injury (IRI) represents a major risk factor for early graft dysfunction and a key obstacle to expanding the donor pool in orthotopic liver…2018 American Transplant Congress
Hyperglycemia-Triggered ATF6-CHOP Pathway Exacerbates Liver Ischemia/Reperfusion Injury: Immunomodulation by Regulating β-Catenin Signaling
Background & Aims: Hyperglycemia is a risk factor for hepatic ischemia/reperfusion injury (IRI) during liver transplantation or hepatectomy; however, the underlying mechanism remains unclear. Our…
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