Articles tagged "Ischemia"

2018 American Transplant Congress
Normothermic Ex Vivo Liver Perfusion Prior to Liver Transplantation Can Prevent Platelet Aggregation and Platelet Induced Sinusoidal Cell Injury
D. Kollmann,¹ I. Linares,¹ S. Ganesh,¹ R. Rosales,¹ N. Tessandier,² E. Boilard,² M. Hamar,¹ P. Urbanellis,¹ P. Yip,³ O. Adeyi,³ M. Selzner,¹ N. Selzner.¹
¹Multi Organ Transplant, UHN, Toronto, Canada; ²Centre Hospitalier de l'Université Laval (CHUL), Québec, Canada; ³Laboratory Medicine and Pathobiology, UHN, Toronto, Canada.
Background. Normothermic ex vivo liver perfusion (NEVLP) is a novel method for graft-preservation applied alternatively to static cold storage (SCS). We examined the impact of…
2018 American Transplant Congress
SIRT1-Ikaros Axis Promotes Macrophage M2 Polarization and Protects Liver Graft from Ischemia-Reperfusion Injury
K. Nakamura,¹ S. Kageyama,¹ X. Li,² A. Aziz,¹ R. Sosa,³ E. Reed,³ F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²NIEHS, Durham, NC; ³Pathology, UCLA, Los Angeles, CA.
Although pre-clinical studies have reported the efficacy of Sirtuin 1 (SIRT1) to protect livers from ischemia-reperfusion injury, its clinical relevance in liver transplantation (LT) has…
2018 American Transplant Congress
Involvement of Aldehyde Dehydrogenase 2 (ALDH2) in Fatty Liver Graft Protection Mechanisms against Cold Ischemic Injury
A. Panisello-Rosello,¹ A. Lopez,² C. Castro,² S. Bellogi,¹ E. Folch-Puy,¹ A. Rolo,³ C. Palmeira,³ R. Adam, J. Roselló-Catafau.
¹Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona, Barcelona, Catalonia, Spain; ²INSERM U935, Hôpital Paul Brousse, Paris, France; ³Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Aldehyde dehydogenase (ALDH2) is a mitochondrial enzyme that recently has been involved in the cardioprotection against ischemia injury. No data are reported on the potential…
2018 American Transplant Congress
Donor and Procedural Variability in DCD Liver Transplant: Is It Time to Come to a Consensus?
L. Ruffolo, M. Balceniuk, R. Hernandez Alejandro.
Department of Surgery, University of Rochester Medical Center on Behalf of the IDOL Consortium, Rochester, NY.
Background:Donation after cardiocirculatory death liver transplantation (DCD LT) has re-emerged in part because of insufficient grafts for patients on waiting lists. Unfortunately, DCD LT has…
2018 American Transplant Congress
Use of Perfusion Machine after Long Cold Ischemia Time: 3 Years Results
A. Matos,¹ L. Requião-Moura,¹ E. Tonato,¹ M. Souza-Durão,^1,2 M. Borrelli,¹ M. Nogueira,¹ P. Rubio,¹ A. Pacheco-Silva.^1,2
¹Transplant, Hospital Israelita Albert Einstein, São Paulo, Brazil; ²Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil.
The rate of delayed graft function (DGF) in Brazil is very high, reaching 80%. This is due to the long cold ischemia time (TIF) and…
2018 American Transplant Congress
Recipient HO-1 Deficiency Decreases Post-Transplant Graft HO-1 Expression and Exacerbates Liver Transplant Damage
S. Kageyama,¹ K. Nakamura,¹ T. Ito,¹ A. Aziz,¹ B. Ke,¹ R. Sossa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Many preclinical studies on protective functions of heme oxygenase-1 (HO-1; hsp32) in orthotopic liver transplantation (OLT) have encouraged application of HO-1 inducing regimens in clinical…
2018 American Transplant Congress
Rictor mTORC2 Signaling Protects Ischemic Liver Injury by Targeting Both Liver Parenchymal and Non-Parenchymal Cells
H. Zhou,¹ Z. Rao,¹ R. Liu,¹ S. Zhou,¹ J. Rao,¹ J. Gu,¹ H. Lu,¹ Y. Xia,¹ X. Wang,¹ Y. Zhai,² L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Mammalian target of rapamycin (mTOR) signaling controls many essential cellular functions. However, the role and its underlying mechanism of Rictor/mTOR complex 2 (mTORC2)…
2018 American Transplant Congress
Umbilical Cords-Derived Mesenchymal Stem Cells Ameliorates Hepatic Ischemia-Reperfusion Injury via Activating the AMPK-mTOR/ULK1 Signaling Pathway Enhanced Autophagy
J. Zheng,^1,2 J. Cai,^1,2 L. Chen,^1,2 J. Yao,^1,2 K. Zeng,^1,2 H. Li,^1,2 Y. Zhang,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
UC-MSCs induction of anti-apoptosis has been indicated to play protective roles in liver ischemia-reperfusion (I/R) model. However, the exact molecular mechanisms of UC-MSCs in hepatic…
2018 American Transplant Congress
Outcomes of Donation after Cardiac Death Liver Grafts from Donors ≥ 50 Years of Age: A Multi-Center Analysis
K. P. Croome,¹ A. K. Mathur,³ D. D. Lee,¹ A. A. Moss,³ C. B. Rosen,² J. K. Heimbach,² C. B. Taner.¹
¹Mayo Clinic Florida, Jacksonville, FL; ²Mayo Clinic Rochester, Rochester, MN; ³Mayo Clinic Arizona, Scottsdale, AZ.
Introduction:As the population in the United States continues to age, an increase in the number of potential DCD donors with advanced chronological age can be…
2018 American Transplant Congress
Recombinant Relaxin Protects Liver Transplants from Ischemia-Reperfusion Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside
S. Kageyama,¹ K. Nakamura,¹ T. Ito,¹ A. Aziz,¹ B. Ke,¹ R. Sossa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Division of Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the…