Articles tagged "Ischemia"

2018 American Transplant Congress
Hypothermic Machine Perfusion Protects Rabbit Kidney Graft through Down Regulation SPP1-MMP7 Signaling Axis
Q. Hu,¹ Z. Zhong,¹ S. Xue,¹ W. Liang,¹ J. Lan,¹ J. Liang,¹ Y. Xiong,¹ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; ²The 3rd Xiangya Hospital of Central Sourth University, Changsha, China.
Background: Multicenter studies have indicated that hypothermic machine perfusion(HMP) can be used to prolong cold ischemia time with high-quality preservation and allow utilization of kidney…
2018 American Transplant Congress
Extracellular Microvesicles from Liver Perfusate: microRNAs, Cellular Cross-Talk, and Early-Post Liver Transplant Outcomes
A. Fernandez,¹ O. Ingram,¹ S. Bontha,¹ U. Erdbruegger,² L. Musante,² V. Mas,¹ D. Maluf.¹
¹Surgery, UVA, Charlottesville; ²Nephrology Division, UVA, Charlottesville.
Background: Ischemia reperfusion injury (IRI) is a multifactorial process that impact liver graft function. Donor quality plays a critical role during IRI and early graft…
2018 American Transplant Congress
Gr1^– Macrophages Play Critical Roles in Liver Inflammation Resolution after IRI via Efferocytosis
M. Ni,^1,2 H. Wang,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu, China.
Inflammation resolution is an integral part of liver ischemia reperfusion injury (IRI), which affects not only the severity of tissue damage, but more importantly its…
2018 American Transplant Congress
The Novel Polymer Pro-Drug APP-103 Reduces I/R Injury and Improves Graft Function in a Pre-Clinical Renal Transplant Model
K. Minami,^1,3 H. Uehara,^1,3 A. Elkhal,^1,3 A. Weins,³ S. Bae,^2,3 J. Reder,⁴ B. Houser,⁴ P. Kang,^2,3 S. Tullius.^1,3
¹Transplant Surgery Division, Department of Surgery, Brigham and Women's Hospital, Boston, MA; ²Beth Israel Deaconess Medical Center, Boston, MA; ³Harvard Medical School, Boston, MA; ⁴Celdara Medical, LLC, Lebanon, NH.
Purpose: Ischemia-reperfusion injury (IRI) is the strongest non-HLA factor that augments allogenicity of transplanted organs. Damage subsequent to IRI is critically linked to an abundance…
2018 American Transplant Congress
Deceased Donor Urinary Biomarker Signature and the Effectiveness of Peritransplant Lymphocyte Depletion on Early Renal Allograft Function
S. Bernd,² P. Heeger,¹ T-.P. Heather,³ I. Hall,⁷ M. Doshi,⁴ F. Weng,⁵ P. Reese,⁶ C. Parikh.³
¹Icahn School of Medicine Mount Sinai, New York, NY; ²University of Ulm, Ulm, Germany; ³Yale University School of Medicine, New Haven, CT; ⁴Wayne State University, Detroit, MI; ⁵Barnabas Health, Livingston, NJ; ⁶University of Pennsylvania, Philadelphia, PA; ⁷University of Utah School of Medicine, Salt Lake City, UT.
Purpose: Delayed graft function (DGF) is associated with increased allogaft immunogenicity and decreased long-term survival. We hypothesized that high levels of donor urinary biomarkers for…
2018 American Transplant Congress
CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes
H. Zhou,¹ Z. Rao,¹ Y. Xia,¹ R. Liu,¹ S. Zhou,¹ X. Wang,¹ Y. Zhai,¹ L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Critical role of endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the role of CCAAT-Enhancer-Binding Protein Homologous…
2018 American Transplant Congress
The Aggressive Phenotype: Center-Level Characteristics in the Use of Suboptimal Lungs
M. Kosztowski, E. Bush, X. Luo, A. Thomas, M. Bowring, D. Segev, J. Garonzik Wang.
Johns Hopkins, Baltimore, MD.
The disparity between organ supply and demand has led some centers to expand their criteria for donor selection. We explored utilization of suboptimal lungs to…
2018 American Transplant Congress
Serelaxin-Notch1 Signaling Promotes Macrophage M2 Differentiation and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation: From Mouse-to-Human
S. Kageyama,¹ K. Nakamura,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Background/Aim: We have documented crucial role of macrophage Notch1 signaling in a mouse warm hepatic ischemia-reperfusion injury (IRI) model. However, its clinical relevance or therapeutic…
2018 American Transplant Congress
TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion
S. Zhou, H. Zhou, R. Liu, F. Zhang, X. Wang, L. Lu.
Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…
2018 American Transplant Congress
Assessing Necroptosis in Brain Dead Kidney Donors: Implications for Predicting Recipient Outcomes
A. Zmijewska, J. Murphy, J. Chen, J. Zmijewski, R. Mannon.
Medicine, University of Alabama at Birmingham, Birmingham, AL.
Introduction: Kidney graft transplant obtained from Brain Dead Donors (BDD) is more frequently associated with development of delayed graft function (DGF) and higher risk of…