Articles tagged "Ischemia"

2019 American Transplant Congress
Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats
W. Wang, L. Qi, J. Huang, A. Ahmadi, A. Krishnan, R. Wesson, A. Cameron, Z. Sun
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) caused by ischemia-reperfusion injury (IRI) is an early complication that occurs in nearly a quarter of all deceased-donor kidneys and…
2019 American Transplant Congress
Fractalkine is Crucial in Ischemia Reperfusion Injury Related to Acute Rejection in an Allogeneic Heart Transplantation Model
T. Kanzawa¹, D. Tokita¹, T. Yamakawa¹, H. Ishigooka¹, H. Fukuda¹, H. Katsumata¹, S. Miyairi¹, R. Ishii¹, T. Hirai¹, K. Saiga¹, M. Okumi¹, T. Imai², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²KAN Research Institute, Kobe, Japan
*Purpose: Ischemia reperfusion injury (IRI) facilitates allograft rejection in renal transplantation recipients (IRI-related rejection). Controlling IRI improves graft survival. Fractalkine (FKN) is an inflammatory chemokine.…
2019 American Transplant Congress
CD4 T Cell is Essential in an Innate-Immune Driven Ischemia-Reperfusion Injury in Mouse and Human
S. Kageyama¹, K. Kadono¹, H. Hirao¹, K. Nakamura¹, T. Ito², K. J. Dery¹, D. Oncel¹, R. A. Sosa³, E. F. Reed³, F. M. Kaldas², R. W. Busuttil², J. W. Kupiec-Weglinski¹, Y. Zhai¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, ³Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA
*Purpose: Although CD4 T cells are critical in the mechanism of allograft rejection, little is known about their role in the innate immune-driven ischemia-reperfusion injury…
2019 American Transplant Congress
An Immediate and Persistent Post-Reperfusion Metabolic Collapse Precedes Delayed Graft Function (DGF)
J. Lindeman
Surgery, Leiden University Medical Center, Leiden, Netherlands
*Purpose: Delayed graft function (DGF) is the manifestation of ischemia reperfusion injury (IRI) in the context of kidney transplantation. Despite clear preclinical successes, a proven…
2019 American Transplant Congress
Determining the Molecular Nature and Role of Cytoglobin in Chronic Allograft Nephropathy
D. Patel¹, T. Divanyan¹, E. Acosta¹, K. Carnes², D. Howard³, F. Jourd’heuil³, D. Jourd’heuil³, R. Lopez-Soler⁴
¹Albany Medical College, Albany, NY, ²Urology, Albany Medical College, Albany, NY, ³Molecular and Cellular Physiology, Albany Medical College, Albany, NY, ⁴Surgery, Section of Transplantation, Albany Medical College, Albany, NY
*Purpose: Although it is usually accepted that the kidney is prone to hypoxic injury, the importance of hypoxia in chronic kidney disease (CKD) as well…
2019 American Transplant Congress
Hypothermic Machine Perfusion Protects Donation After Cardiac Deathliver Graft Through Gstm1-mediated Cytochrome P450 Exogenous Substance Metabolism Pathway
W. Liang, S. Ye, Z. Zhong, Q. Hu, Y. Wang, Q. Ye
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases, Wuhan, China
*Purpose: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…
2019 American Transplant Congress
Prolonged Cold Ischemic Storage Induces Allograft Necro-Inflammation That Increases Graft Susceptibility to T Cell Mediated Rejection
N. Chun¹, R. Ang¹, J. Horwitz¹, R. Fairchild², W. Baldwin III², A. Ting¹, P. S. Heeger¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged cold ischemic storage (CIS) of murine cardiac allografts causes complement dependent, CTLA4Ig-resistant rejection that is associated with 48h post-transplant elevations in serum levels…
2018 American Transplant Congress
The First Series of Ischemia-Free Liver Transplantation in Human
X. He,¹ Z. Guo,¹ S. Huang,¹ Q. Zhao,¹ Y. Tang,¹ Z. Zhang,¹ Z. Zhu,¹ W. Ju,¹ L. Yang,² G. Chen.¹
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND&AIMS: Ischemia and reperfusion injury (IRI) is known as an inevitable event leading to early and late graft failure. We have performed the first case…
2018 American Transplant Congress
Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver Resident Macrophage M2 Polarization via C/EBP-Homologous Protein-Mediated Endoplasmic Reticulum Stress
Z. Rao, J. Sun, X. Pan, Z. Chen, H. Sun, P. Zhang, M. Gao, Z. Ding, C. Liu.
Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Background:Aggravated liver ischemia and reperfusion (IR) injury has been observed in hyperglycemic hosts, but its underlying mechanism remains undefined. The aim of the study was…
2018 American Transplant Congress
Endothelin A Receptor (ETaR) siRNA Ameliorates Renal Ischemia Reperfusion Injury through Upregulating Expression of eNOS in Rats
Y. Jia, L. Li, T. Zhu.
Shanghai Key Labratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Aims: To explore the protective effect of Endothelin A Receptor (ETaR) siRNA on renal ischemia reperfusion injury and its underlying mechanism.Methods: The model of unilateral…