Articles tagged "Ischemia"

2019 American Transplant Congress
Evaluation of New Baskent University Preservation Solution for Liver, Kidney and Intestine Graft during Cold Ischemia: Preliminary Experimental Animal Study
M. Haberal¹, M. Kirnap¹, R. Erdem², H. Ozdemir³, M. Lux², D. Bacanli⁴
¹Transplantation, Baskent University, Ankara, Turkey, ²Pharmacology, Baskent University, Ankara, Turkey, ³Pathology, Baskent University, Ankara, Turkey, ⁴Experimental Laboratory, Baskent University, Ankara, Turkey
*Purpose: Despite significant advances in organ transplantation, damage caused to organs due to long cold ischemia time and perfusion solutions remains a serious hurdle. The…
2019 American Transplant Congress
Ischemia-Free Liver Transplantation Protects Bile Duct from Ischemia/Reperfusion Injury
J. Yang, S. Huang, Z. Zhang, Q. Zhao, W. Ju, Z. Zhu, Y. Tang, L. Wang, Y. Zhang, C. Sun, L. Wu, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Ischemia-free liver transplantation (IFLT), based on normothermic machine perfusion and innovations in surgical technique, can provide continue blood supply from procurement to implantation that…
2019 American Transplant Congress
Complete Robotic-Assisted Kidney Transplantation: Our Initial Experience
A. Khan, C. Bhati, T. Reichman, A. Cotterell, D. Kumar, G. Gupta, L. Kamal, A. King, A. Sharma, M. Levy
VCU Medical Center, Richmond, VA
*Purpose: Kidney transplantation is the standard treatment for patients with ESRD. Very limited advancement has been made in its surgical aspects. Minimal invasive approach for…
2019 American Transplant Congress
Normothermic Regional Perfusion of Kidneys: A Single Non-Retrieval Centre Experience
R. Pearson, C. Geddes, M. Clancy, J. Asher
Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom
*Purpose: With the aim of safely expanding the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional (NRP) perfusion…
2019 American Transplant Congress
Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation
A. Hosszu¹, Z. Antal², L. Illesy², L. Lenart¹, D. B. Balogh¹, L. Wagner³, A. Vannay⁴, A. J. Szabo², A. Fekete¹
¹"Lendulet" Diabetes Research Group, MTA-SE, Budapest, Hungary, ²1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Pediatrics and Nephrology Research Group, MTA-SE, Budapest, Hungary
*Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…
2019 American Transplant Congress
Recombinant Apoptosis Inhibitor of Macrophage Protein Ameliorates Transplant Ischemia-Reperfusion Injury
J. Y. Lee¹, X. Zhang², D. Lian³, A. R. Haig⁴, T. Miyazaki⁵, L. Gunaratnam⁶
¹Department of Microbiology and Immunology, Western University, London, ON, Canada, ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada, ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, Lodnon, ON, Canada, ⁴Department of Pathology, Western University, London, ON, Canada, ⁵Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo, Japan, ⁶Department of Medicine, Western University, London, ON, Canada
*Purpose: Ischemia-reperfusion injury (IRI) during kidney transplantation is associated with acute rejection and long-term graft loss. During IRI, pro-inflammatory mediators (e.g. HMGB1) released from necrotic…
2019 American Transplant Congress
The Impact of Thrombin / Protease-Activated Receptor-1 Pathway in Hepatic Ischemia-Reperfusion Injury in Mice
D. Noguchi, N. Kuriyama, T. Fujii, H. Kato, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
*Purpose: Coagulation cascade is an important pathway in the pathophysiology of hepatic ischemia-reperfusion injury(IRI). Generation of thrombin is a critical factor of coagulation induced by…
2019 American Transplant Congress
Effects of Pretreated Bortezomib on Renal Function after Renal Ischemia – Reperfusion Injury in Mice
X. Zheng
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: To observe the effects of pretreated bortezomib at different points on renal function and renal histology after renal ischemia-reperfusion injury in mice.*Methods: A mice…
2019 American Transplant Congress
Hepatocyte SIRT1 Modulates ATF4/CHOP and Mitigates Liver Transplant Ischemia-Reperfusion Injury: From Bench-to-Bedside
H. Hirao¹, S. Kageyama¹, K. Kadono¹, K. Nakamura¹, T. Ito¹, K. J. Dery¹, D. Oncel¹, X. Li², B. Ke¹, F. M. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec‐Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, ²National Institute of Environmental Health Sciences, Research Triangle Park, NC
*Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation against hepatic ischemia-reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Although…
2019 American Transplant Congress
Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK
D. Choi¹, J. Jeong², K. Lee¹, K. Na¹, Y. Chang³, Y. Ham¹, J. Jeon¹, H. Kim¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…