ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Ischemia"

  • 2020 American Transplant Congress

    Metabolism Reprogramming During Conventional versus Ischemia-Free Liver Transplantation

    Z. Guo1, Z. Zhang1, N. Gao1, H. Zhang2, X. He1

    1Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2Sun Yat-sen University, Guangzhou, China

    *Purpose: Our group has developed a novel transplant procedure called ischemia-free liver transplantation (IFLT), during which the liver can be procured, preserved and implanted without…
  • 2020 American Transplant Congress

    Rouleaux Formation in Human Livers During Normothermic Machine Perfusion

    M. Harris1, S. Raigani2, C. Albert3, M. Reschke3, C. Carroll2, J. T. Langford1, C. Edwards4, D. Mulligan4, D. Haakinson1, K. Uygun2, H. Yeh2, G. Tietjen1

    1Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, 2Division of Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Yale School of Engineering and Applied Science, New Haven, CT, 4Surgery, Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT

    *Purpose: We recently discovered that red blood cells form rouleaux plugs in human kidney vasculature during normothermic machine perfusion (NMP) and are associated with poor…
  • 2020 American Transplant Congress

    Ikaros Regulates Macrophage Inflammation in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human

    K. Kadono1, S. Kageyama1, K. Nakamura1, H. Hirao1, H. Kojima1, T. Ito1, K. J. Dery1, X. Li2, R. W. Busuttil1, F. Kaldas1, J. W. Kupiec-Weglinski1

    1Liver Transplant Surgery, UCLA, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor for early allograft dysfunction and rejection episodes in liver transplantation (LT). The impact of Ikaros,…
  • 2020 American Transplant Congress

    The Impact of a Positive Crossmatch on KAS Patients and Organs

    J. Lee1, K. Sjöholm2, C. Kjellman2, T. Lorant2, L. Winstedt2, V. Nigro2, K. M. Roupé2, Å. Schiött2, A. Runstrom2, S. Taranto3, T. Baker3, D. Stewart3

    1Medical Affairs, Hansa Biopharma, Camas, WA, 2Hansa Biopharma, Lund, Sweden, 3UNOS, Richmond, VA

    *Purpose: Evaluate the potential effects of offer refusals due to positive crossmatch (+XM) on both patients and re-allocated organs with a focus on waitlist outcomes,…
  • 2020 American Transplant Congress

    Paired-Donor Kidney Exchange Has Comparable Early Graft Function to Directed Living Donor

    E. McCracken, A. Sites, B. Rawashdeh, A. Nishio-Lucar, A. Agarwal

    Transplant Surgery, University of Virginia, Charlottesville, VA

    *Purpose: Living kidney donation in the United States is associated with improved graft and patient survival. However, there is minimal data on graft function in…
  • 2020 American Transplant Congress

    Experimental Porcine Pancreatic Allotransplantation after Hypothermic Perfusion

    T. Prudhomme1, D. Kervella1, K. Renaudin2, V. Gauttier1, S. Le Bas-Bernardet3, D. Minault3, J. Hervouet3, D. Cantarovich1, G. Karam1, G. Blancho1, J. Branchereau1

    1Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France, 2Département d’Anatomie et de Cytologie Pathologique, CHU Nantes, Nantes, France, 3Centre de Recherche en Transplantation et Immunologie, UMR1064, INSERM, Université de Nantes, Nantes, France

    *Purpose: The main objective of this study was to compare the different preservation techniques (static cold storage (SCS) and hypothermic pulsatile perfusion (HPP)) in a…
  • 2020 American Transplant Congress

    Targeting CD62 – CD162 Signaling with a Soluble Form of a Tandem-PSGL-1 in a Murine Model of Hindlimb Transplantation

    K. Kadono1, F. Messner2, Y. Guo2, B. Oh2, G. Brandacher2, J. W. Kupiec-Weglinski1

    1Liver Transplant Surgery, UCLA, Los Angeles, CA, 2Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Static cold storage (SCS) times for organs and tissues are currently limited to hours. Once outside the body, tissues lack oxygen and nutrient supply…
  • 2020 American Transplant Congress

    Aging Aggravated Liver Ischemia and Reperfusion Injury by Promoting Sting-Mediated NLRP3 Activation in Macrophages

    Z. Rao, W. Zhong, H. Zhou, P. Wang, X. Wang, L. Lu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Aggravated liver injury and enhanced intrahepatic inflammation was found in old livers post ischemia and reperfusion (IR). However, the function and underlying mechanism of…
  • 2020 American Transplant Congress

    The Impact of Cold Ischaemia Time on Living Donor Kidney Transplantation Outcomes

    S. C. van de Laar1, M. Robb2, R. Hogg2, V. Papalois1, F. J. Dor1

    1Department of Surgery & Cancer, Imperial College London, Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, White City, London, United Kingdom, 2NHS Blood and Transplant, Bristol, United Kingdom

    *Purpose: Living donor KTx (LDKT) provides the best option for patients with end-stage kidney disease (ESKD). ESKD patients who have an incompatible living donor still…
  • 2020 American Transplant Congress

    Consistent Prevention of Perioperative Cardiac Xenograft Dysfunction with Non-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model

    C. E. Goerlich1, A. Singh1, D. Kaczorowski1, M. Abdullah1, B. Lewis1, I. Tatarov1, A. Hershfeld1, T. Zhang1, P. Odonkor1, A. Tabatabai1, A. Bhutta1, E. Strauss1, B. Williams1, D. Ayares2, M. Mohiuddin1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor, Blacksburg, VA

    *Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
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