Articles tagged "Intestinal transplantation"

2021 American Transplant Congress
Should We Worry About Covid-19 Infection in Pediatric SOT?
U. Ekong¹, S. Paul¹, S. Royal², J. Chahine³, N. Yazigi¹, S. Kaufman¹, K. Khan¹, C. Matsumoto¹, A. Kroemer¹, T. Fishbein¹
¹Surgery, Medstar Georgetown Transplant Institute, Washington, DC, ²Pediatrics, Medstar Georgetown University Hospital, Washington, DC, ³Pathology and Laboratory Medicine, Medstar Georgetown University Hospital, Washington, DC
*Purpose: We describe the clinical presentation & immune response to COVID-19 infection in pediatric SOT.*Methods: Medical records of COVID-19 PCR+ or seropositive patients were reviewed…
2021 American Transplant Congress
RNA Sequencing (RNAseq) Tissue Analysis Can Provide Early Warning Signals for Potential Intestinal Transplant Complications
J. Kang¹, L. Belyayev¹, O. Aguirre¹, K. Khan¹, Y. Gusev², K. Bhuvaneshwar², H. Ressom³, J. Hawksworth¹, C. Matsumoto¹, T. Fishbein¹, A. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Georgetown University Medical Center, Innovation Center for Biomedical Informatics, Washington, DC, ³Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC
*Purpose: A disrupted mucosal barrier in intestinal grafts can cause alloreactive complications such as rejection, inflammation and infection following intestinal transplantation (ITx). We hypothesize that…
2021 American Transplant Congress
Segmental Susceptibility of Intestinal Stem Cells to Cold Storage Preservation Injury in a Porcine Model
E. K. Ludwig¹, N. Abraham², D. Sudan², A. Barbas², C. Schaaf¹, J. Freund¹, A. S. Stewart¹, B. Veerasammy¹, L. M. Gonzalez¹
¹North Carolina State University, Raleigh, NC, ²Duke University, Durham, NC
*Purpose: Cold storage (CS) is the current gold standard preservation method for small bowel (SB) prior to transplantation. However, CS can cause epithelial detachment, sloughing,…
2021 American Transplant Congress
The Impact of Early Narcotic Administration on Intestinal Transplantation Survival at an Urban Medical Center
L. Maliekal¹, N. Beltran², Y. Muszkat², S. Nagai², S. Jafri²
¹School of Medicine, Wayne State University School of Medicine, Detroit, MI, ²Department of Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: The impact of early narcotic administration on intestinal transplant patients is not well understood, with current practice suggesting the avoidance of narcotics among transplant…
2021 American Transplant Congress
Peri-covid Trends on the Intestinal Transplant Waiting List
M. L. Samoylova¹, S. Jafri², M. I. Fiel³, S. Horslen⁴, A. Mavis⁵, T. Schiano⁶, B. Summers⁷, M. C. Segovia⁸
¹Surgery, Duke University, Durham, NC, ²Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI, ³Pathology, Mount Sinai, New York, NY, ⁴Transplantation, Seattle Children's Hospital, Seattle, WA, ⁵Pediatric Gastroenterology, Duke University, Durham, NC, ⁶Hepatology, Mount Sinai Medical Center, New York, NY, ⁷Pharmacy, Henry Ford Hospital, Detroit, MI, ⁸Gastroenterology, Duke University, Durham, NC
*Purpose: We aim to describe the trends in intestinal and multivisceral transplant waiting list activity and outcomes before and after the COVID-19 pandemic.*Methods: We used…
2020 American Transplant Congress
Trends in Intestinal and Multivisceral Transplantation in the United States over 30 Years
M. L. Samoylova¹, J. Yerxa¹, B. I. Shaw¹, S. Horslen², S. Jafri³, A. Mavis⁴, T. Schiano⁵, B. Summers⁶, A. S. Barbas¹, D. L. Sudan¹, M. C. Segovia⁴
¹Surgery, Duke University Hospital, Durham, NC, ²Ped Gastroenterology, Seattle Childrens' Hospital, Seattle, WA, ³Gastroenterology, Henry Ford Hospital, Detroit, MI, ⁴Gastroenterology, Duke University Hospital, Durham, NC, ⁵Gastroenterology, Mt Sinai Hospital, New York, NY, ⁶Transplant Pharmacy, Henry Ford Hospital, Detroit, MI
*Purpose: We describe trends in intestinal transplantation use and outcomes over time in the USA.*Methods: We use the cohort of intestinal and multivisceral transplants 1990-2019…
2020 American Transplant Congress
A Nonhuman Primate Model of Intestinal Transplantation – Technical Aspects and Early Outcomes
R. Schmitz¹, J. Yoon¹, M. Song¹, E. Jelly², A. P. Wax², S. J. Knechtle¹, D. L. Sudan¹, J. Kwun¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Biomedical Engineering, Duke University, Durham, NC
*Purpose: Intestinal transplantation (IT) is the treatment of choice for patients with irreversible intestinal failure that experience complications from total parenteral nutrition. Long-term outcomes after…
2020 American Transplant Congress
Pediatric Renal Transplant after Intestinal Transplant – Technical Challenges and Outcomes
A. Amin, B. Emmanuel, Y. Chang, G. Bond, A. Khanna, K. Soltys, R. Sindhi, A. Tevar, A. Humar, G. Mazariegos, A. Ganoza
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: There is no data in the literature about outcomes of pediatric intestinal transplant (IT) recipients, who require renal transplant after intestinal transplant (RTAIT). The…
2020 American Transplant Congress
Correlation of CMV and EBV DNAemia in the Development of Invasive Fungal Disease among Pediatric Intestinal and Liver Transplant Recipients
B. M. Chatani¹, J. Garcia², T. Beduschi³, A. Tekin³, R. Vianna³, I. A. Gonzalez¹
¹Pediatric Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, ²Pediatric Gastroenterology, University of Miami Miller School of Medicine, Miami, FL, ³Miami Transplant Institute, Miami, FL
*Purpose: Invasive fungal disease (IFD) among pediatric solid organ transplant recipients is a relatively rare event, however often results in death. There are many factors…
2020 American Transplant Congress
A Mouse Model of Paratopic Intestinal Transplantation to Delineate GVHD-Free Alloimmune Rejection Responses
A. Dangi¹, J. Wang², A. Joseph³, J. Roper³, N. Surana⁴, X. Luo¹
¹Nephrology/Medicine, Duke University, Durham, NC, ²Surgery, Duke University, Durham, NC, ³Gastroenterology/Medicine, Duke University, Durham, NC, ⁴Molecular Genetics and Microbiology, Duke University, Durham, NC
*Purpose: Current clinical practice of intestinal transplantation is limited due to a high rate of graft failure and patient mortality. In the present study, we…