2018 American Transplant Congress
Bloodstream Infection Caused by Enteric Organisms during the First 6 Months after Intestinal Transplant
1Medicine/Infectious Diseases, University of Miami, Miami; 2Surgery, University of Miami, Miami.
Background: Irreversible intestinal failure can be treated effectively with intestinal transplant (ITx). Infections are common after ITx but data on bloodstream infection (BSI) due to…2018 American Transplant Congress
Depletion Resistant Effector Memory T Cells Mediate Thymoglobulin Refractory Allograft Rejection in Human Intestinal Transplant Recipients
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. This study aimed to determine the mechanisms underlying T cell depletion-resistant moderate to severe acute cellular rejection (ACR) in intestinal transplantation (ITx) patients.B. A…2018 American Transplant Congress
Increased Pre-Transplant Rejection-Risk Measured with Allospecific T-Cells Predicts Delayed Immunosuppression Minimization in Children with Intestine Transplantation.
Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
BACKGROUND: Allospecific CD154+T-cytotoxic memory cells (CD154+TcM) are used clinically to predict acute cellular rejection (ACR) after intestine transplantation (ITx) in children <21 years old within…2018 American Transplant Congress
The Protective Effect of Multivisceral Transplantation on Intestinal Allograft Rejection – Its Correlation with T-Cell Macrochimerism from a Long-Term Prospective Study
Objective Graft rejection remains the crux of intestinal transplantation. Although liver-inclusive grafts appear to be protective, the mechanism remains unknown. We hypothesize that T-cell macrochimerism…2018 American Transplant Congress
Temporal and Geographical Trends of Intestinal Transplantation in the USA
Intestinal transplantation (IT) is uncommon compared to other organ transplants. We examined the temporal and geographical trends of centers that perform IT in the USAWe…2018 American Transplant Congress
CD8+ Tissue Resident Memory T Cells Are Key Effector Cells in Intestinal Transplantation Patients with GvHD
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. As the pathophysiologic role of Tissue Resident Memory T Cells (TRM) in intestinal transplantation (ITx) is unknown, this study aims to test the hypothesis…2018 American Transplant Congress
Development of a Novel Assay System for Ex Vivo T-Cell Mediated Rejection Responses in Intestinal Grafts
In intestinal transplantation, the intestinal allograft (IA) presents a formidable challenge for control of alloimmune responses due to constitutive MHC class II expression by intestinal…2018 American Transplant Congress
Cytomegalovirus (CMV) Infection in Small Intestinal and Multivisceral Transplant Recipients: The Role of Donor Selection on CMV Incidence and Outcomes
Medstar Georgetown University Hospital, Washington DC.
Introduction: CMV infection remains an important cause of morbidity, allograft enteritis, and allograft loss in small intestinal (SIT) and multivisceral transplant (MVT) recipients. As the…2018 American Transplant Congress
Tacrolimus and Isavuconazole Therapy: What about the Drug Interaction?
1Henry Ford Hospital, Detroit; 2Wayne State University, Detroit, MI.
Introduction:Isavuconazole (ISV) is a triazole antifungal that is often utilized in solid organ transplant recipients (SOTR) for the treatment of invasive aspergillosis and mucormycosis. Isavuconazole…2018 American Transplant Congress
Immunomonitoring of Operational Tolerance in Intestinal Transplantation
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. The purpose of this study is to immunocharacterize the first reported case of intestinal transplant (ITx) operational tolerance, in parallel with a stable ITx…
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