Articles tagged "Intestinal transplantation"

2021 American Transplant Congress
RNA Sequencing (RNAseq) Tissue Analysis Can Provide Early Warning Signals for Potential Intestinal Transplant Complications
J. Kang¹, L. Belyayev¹, O. Aguirre¹, K. Khan¹, Y. Gusev², K. Bhuvaneshwar², H. Ressom³, J. Hawksworth¹, C. Matsumoto¹, T. Fishbein¹, A. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Georgetown University Medical Center, Innovation Center for Biomedical Informatics, Washington, DC, ³Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC
*Purpose: A disrupted mucosal barrier in intestinal grafts can cause alloreactive complications such as rejection, inflammation and infection following intestinal transplantation (ITx). We hypothesize that…
2021 American Transplant Congress
Should We Worry About Covid-19 Infection in Pediatric SOT?
U. Ekong¹, S. Paul¹, S. Royal², J. Chahine³, N. Yazigi¹, S. Kaufman¹, K. Khan¹, C. Matsumoto¹, A. Kroemer¹, T. Fishbein¹
¹Surgery, Medstar Georgetown Transplant Institute, Washington, DC, ²Pediatrics, Medstar Georgetown University Hospital, Washington, DC, ³Pathology and Laboratory Medicine, Medstar Georgetown University Hospital, Washington, DC
*Purpose: We describe the clinical presentation & immune response to COVID-19 infection in pediatric SOT.*Methods: Medical records of COVID-19 PCR+ or seropositive patients were reviewed…
2021 American Transplant Congress
A Comparison of Pediatric Intestine Transplant Between the Current Era (2015-2019) and the Peak Period (2002-2006)
S. Horslen¹, T. Weaver², M. Skeans²
¹Seattle Children's Hospital, Seattle, WA, ²SRTR, Minneapolis, MN
*Purpose: Demand for intestine transplants in children grew from its clinical inception in the late 1980s to a peak in 2007 of 111 small bowel-containing…
2021 American Transplant Congress
Peri-covid Trends on the Intestinal Transplant Waiting List
M. L. Samoylova¹, S. Jafri², M. I. Fiel³, S. Horslen⁴, A. Mavis⁵, T. Schiano⁶, B. Summers⁷, M. C. Segovia⁸
¹Surgery, Duke University, Durham, NC, ²Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI, ³Pathology, Mount Sinai, New York, NY, ⁴Transplantation, Seattle Children's Hospital, Seattle, WA, ⁵Pediatric Gastroenterology, Duke University, Durham, NC, ⁶Hepatology, Mount Sinai Medical Center, New York, NY, ⁷Pharmacy, Henry Ford Hospital, Detroit, MI, ⁸Gastroenterology, Duke University, Durham, NC
*Purpose: We aim to describe the trends in intestinal and multivisceral transplant waiting list activity and outcomes before and after the COVID-19 pandemic.*Methods: We used…
2021 American Transplant Congress
The Impact of Early Narcotic Administration on Intestinal Transplantation Survival at an Urban Medical Center
L. Maliekal¹, N. Beltran², Y. Muszkat², S. Nagai², S. Jafri²
¹School of Medicine, Wayne State University School of Medicine, Detroit, MI, ²Department of Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: The impact of early narcotic administration on intestinal transplant patients is not well understood, with current practice suggesting the avoidance of narcotics among transplant…
2021 American Transplant Congress
Segmental Susceptibility of Intestinal Stem Cells to Cold Storage Preservation Injury in a Porcine Model
E. K. Ludwig¹, N. Abraham², D. Sudan², A. Barbas², C. Schaaf¹, J. Freund¹, A. S. Stewart¹, B. Veerasammy¹, L. M. Gonzalez¹
¹North Carolina State University, Raleigh, NC, ²Duke University, Durham, NC
*Purpose: Cold storage (CS) is the current gold standard preservation method for small bowel (SB) prior to transplantation. However, CS can cause epithelial detachment, sloughing,…
2020 American Transplant Congress
Allograft Repopulating Recipient B Cells after Human Intestinal Transplantation and Their Association with Donor Specific Antibody Secretion and Rejection
E. Waffarn¹, J. Fu¹, K. Frangaj¹, W. Meng², A. M. Rosenfeld², M. Li³, K. Rodgers¹, R. Vasilescu³, E. T. Luning Prak², A. Griesemer¹, T. Kato⁴, M. Martinez⁵, M. Sykes¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, ³Department of Pathology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY, ⁵Department of Pediatrics, Columbia University, New York, NY
*Purpose: Alloantibodies produced by recipient B cells are associated with rejection after intestinal transplantation (ITx) and negatively impact patient and graft survival. However, the dynamics…
2020 American Transplant Congress
Intestinal Retransplantation: Survival Outcomes Similar to Primary Transplantation
C. Beyersdorf, L. Vargas, D. Mercer, W. Grant, A. Langnas, S. Merani
University of Nebraska Medical Center, Omaha, NE
*Purpose: Isolated and multivisceral intestinal transplantation is indicated for patients with life threatening complications of intestinal failure. Intestinal retransplantation has been performed in select intestinal…
2020 American Transplant Congress
Kidney after Intestinal Transplantation: A Comparison with Combined Kidney with Intestinal Transplant. A UNOS Database Analysis
A. Sharfuddin, M. Panezai, O. Adebiyi, T. Taber, M. Yaqub
Indiana University School of Medicine, Indianapolis, IN
*Purpose: There is limited data on outcomes for patients receiving a isolated kidney transplant (KAIT) after any prior Multi-organ or Isolated Intestinal transplant (IT). We…
2020 American Transplant Congress
Trends in Intestinal and Multivisceral Transplantation in the United States over 30 Years
M. L. Samoylova¹, J. Yerxa¹, B. I. Shaw¹, S. Horslen², S. Jafri³, A. Mavis⁴, T. Schiano⁵, B. Summers⁶, A. S. Barbas¹, D. L. Sudan¹, M. C. Segovia⁴
¹Surgery, Duke University Hospital, Durham, NC, ²Ped Gastroenterology, Seattle Childrens' Hospital, Seattle, WA, ³Gastroenterology, Henry Ford Hospital, Detroit, MI, ⁴Gastroenterology, Duke University Hospital, Durham, NC, ⁵Gastroenterology, Mt Sinai Hospital, New York, NY, ⁶Transplant Pharmacy, Henry Ford Hospital, Detroit, MI
*Purpose: We describe trends in intestinal transplantation use and outcomes over time in the USA.*Methods: We use the cohort of intestinal and multivisceral transplants 1990-2019…

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