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Articles tagged "Inflammation"

  • 2015 American Transplant Congress

    Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation

    H. Ono,1 Y. Asahi,1 T. Yoshida,1 Y. Koshizuka,1 M. Watanabe,1 U. Tomaru,2 S. Emoto,1 M. Fukai,3 A. Taketomi,1 S. Todo,4 K. Yamashita.3

    1Gastroenterological Surgery1, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 2Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 3Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 4St Mary's Hospital, Kurume, Japan.

    Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…
  • 2015 American Transplant Congress

    Inflammasome Activation in Hepatocytes and Kupffer Cells Orchestrates the Hepatotoxic Effect of Bile Acids and Can Be Potential Target in the Management of Cholestatic Liver Injury

    X. Liu,1 T. Ma,1 T. Billiar,2 R. Tao.1

    1Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; 2Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

    Purpose: Cholestatic liver injury (CLI) is commonly associated with many hepatobiliary diseases and substantially increases the peri-operative morbidity and mortality in liver surgery and transplantation.…
  • 2015 American Transplant Congress

    A Non-Haematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents the Transplanted Islet Graft Damage

    M. Watanabe,1 T. Lundgren,1 Y. Saito,1 A. Cerami,2 M. Brines,2 C.-G. östenson,3 M. Kumagai-Braesch.1

    1Division of Transplantation Surgery, Karolinska Institutet, Stockholm, Sweden; 2Araim Pharmaceuticals, Tarrytown, NY; 3Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

    Purpose. Pancreatic islet transplantation (PITx) is an attractive treatment option for type 1 diabetes patients. While pancreatic islets can successfully engraft after PITx a large…
  • 2015 American Transplant Congress

    Immunologic, Proangiogenic and Neurogenic Assessment of Allogenic Epineurium of the Human Peripheral Nerve for Potential Application in Prevention of Neuroma Formation

    A. Klimczak,1 K. Futoma,2 A. Jundzill,3 D. Patrzalek,4 M. Siemionow.5

    1Clinical Immunology Department, Institute of Immunology and Experimental Therapy PAS, Wroclaw, Poland; 2Wroclaw Research Centre EIT+, Wroclaw, Poland; 3Regenerative Medicine Tissue Engineering Department, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland; 4Department of Surgery, 4th Military Clinical Hospital, Wroclaw, Poland; 5Department of Orthopaedics, The University of Illinois at Chicago, Chicago, IL.

    Purpose: Transplantation of epineural sheath may support nerve regeneration after traumatic nerve injuries. Unsolved problem after nerve injury is painful neuroma formation. Natural biologic material,…
  • 2015 American Transplant Congress

    The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury

    S. Kasimsetty, A. Shigeoka, D. McKay.

    Medicine, UCSD, La Jolla, CA.

    Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…
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