2015 American Transplant Congress
Enhanced Production of Macrophage Chemoattractant Protein-1 (MCP-1) Within the Kidney in Brain Death Donors Predicts Recipient Allograft Function
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Brain death (BD) induces an intense pro-inflammatory state, which may impact recipient immunity and graft function after kidney transplantation. The identification of biomarkers predictive of…2015 American Transplant Congress
Donor Organ Resident M2 Type Myeloid Cells Protect Murine Orthotropic Liver Transplants from Ischemia and Reperfusion Injury
The Dumont-UCLA Transplant Ctr., UCLA, Los Angeles, CA.
Liver ischemia reperfusion injury (lRI) is mediated by a pro-inflammatory immune response initiated by the activation of liver non-parenchymal innate immune cells, such as Kupffer…2015 American Transplant Congress
Predictive Value of Postoperative CRP and Procalctonin in Kidney Donors Experiencing Surgical Complications
Renal and Pancreatic Transplantation, Guy's Hospital, London, United Kingdom.
Introduction: Patients undergoing donor nephrectomy are fit and well individuals. Despite this, 1 in 5 will suffer a perioperative complication causing significant morbidity. Recent published…2015 American Transplant Congress
Perfusion Disturbances and Local Infarctions After Experimental Kidney Transplantation Corralte With the Duration of Cold Ischemia Time
Background: Kidney transplantation in mice is challenging but offers good translational models to study mechanisms of disease. In this study allogenic and isogenic kidney transplantation…2015 American Transplant Congress
Galectin-9 Protects Mouse Liver Transplants Against Ischemia-Reperfusion Injury
Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA.
Background:Although Galecin 9 (Gal-9) negatively regulates Th1-type alloimmunity by binding to T-cell Immunoglobulin Mucin-3 (TIM-3) on activated Th1 cells, its role in liver ischemia-reperfusion injury…2015 American Transplant Congress
AAV-Mediated TIMP-1 Gene Therapy Ameliorates Hepatic Ischemia/Reperfusion Injury
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…2015 American Transplant Congress
Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)
Microvascular endothelium is major target for antibodies directed against HLA and non-HLA antigens. Functional antibodies targeting G-protein coupled receptors (GPCRs) such as AT1R or ETAR…2015 American Transplant Congress
Low Molecular Weight Hyaluronan Increases MIG and MCP-1 Production in Cardiac Allografts
1Immunology, Cleveland Clinic, Cleveland, OH; 2Pathobiology, Cleveland Clinic, Cleveland, OH.
Macrophages engage in extracellular matrix remodeling both degrading and synthesizing hyaluronan. Hyaluronan is a high molecular weight ( > 1000 kDa) extracellular matrix component that…2015 American Transplant Congress
Th17 Mediates Inflammatory Responses After Lung Transplantation
Background: Long-term outcomes after lung transplantation are markedly worse than for other organs. The mechanisms that determine lung transplant rejection are not clear. The role…2015 American Transplant Congress
Bariatric Surgery Prolongs Allograft Survival by Promoting Th2 Conditions
Background: Obesity is linked to chronic low-grade inflammation. We hypothesized that I) obesity will accelerate allograft rejection linked to pro-inflammatory immune responses and that II)…
American Transplant Congress abstracts