Articles tagged "Inflammation"

2015 American Transplant Congress
Tandem P-Selectin Glycoprotein Ligand-Immunoglobulin (TSGL-Ig) Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation
C. Zhang,¹ H. Ji,¹ Y. Liu,¹ X. Shen,¹ F. Gao,¹ R. Busuttil,¹ G. Shaw,² J. Kupiec-Weglinski.¹
¹Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA; ²Quell Pharma Inc., Half Moon Bay, CA.
Background: Liver endothelial cell (LEC) damage is central in the pathogenesis of hepatic ischemia-reperfusion injury (IRI). LEC detachment/progressed denudation are typical during cold storage and…
2015 American Transplant Congress
Isolated Microcirculation Inflammation Negatively Impacts Renal Graft Function at 5 Years
A. Chapelet,¹ M. Touzot,¹ M. Fournier,² A. Cesbron,³ K. Renaudin,⁴ A. Moreau,⁴ E. Morelon,⁵ D. Anglicheau,⁶ M. Giral.¹
¹Institut de Transplantation Urologie Néphrologie, CHU Nantes, Nantes, France; ²EA 4275 SPHERE—Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences, University of Nantes, Nantes, France; ³Etablissement Français du Sang (EFS), Nantes, France; ⁴Service d'Anatomie et Cytologie Pathologiques, CHU Nantes, Nantes, France; ⁵Service de Néphrologie, Transplantation et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France; ⁶Service de Transplantation Rénale et de Soins Intensifs, Hôpital Necker, Paris, France.
BACKGROUND: Microcirculation inflammation (MI, ie: glomerulitis (g) and peritubular capillaritis (ptc)) associated with anti-HLA Donor Specific Antibody (DSA) with or without C4d deposits in ptc…
2015 American Transplant Congress
Detection of Donor-Specific Anti-HLA Antibodies Is Associated With Changes in the Peripheral Distribution of NK Cell Subsets in Kidney Allograft Recipients
M. Crespo,¹ D. Redondo,¹ J. Yelamos,² A. Muntasell,² M. Pérez-Sáez,¹ M. Lopez-Montañes,³ C. Garcia,⁴ A. Torío,⁵ J. Hernandez,⁴ M. Mir,¹ M. Lopez-Botet,³ J. Pascual.¹
¹Nephrology, Hospital del Mar, Barcelona, Spain; ²Servicio de Inmunología, Institut Mar d'Investigacions Mediques, Barcelona, Spain; ³Grup de Investigacio en Immunologia, Universitat Pompeu Fabra, Barcelona, Spain; ⁴Laboratori de Referencia de Catalunya, Barcelona, Spain; ⁵Immunology Unit, Hospital de Alicante, Alicante, Spain.
Background: Microvascular damage has become the real protagonist involved in antibody-mediated rejection and NK-cell antibody-dependent cell mediated cytotoxicity (ADCC) has been proposed as a contributing…
2015 American Transplant Congress
Loss of RIPK3 and Caspase-8 Enhance Intrinsic Apoptosis in Tubular Epithelial Cell (TEC) Death and Contributes to Kidney Ischemia Reperfusion Injury (IRI)
B. Sung,¹ Y. Su,³ A. Lau,³ J. Jiang,³ A. Haig,² D. Green,⁴ Z. Zhang,² A. Jevnikar.¹
¹Microbiology and Immunology, Western University, London, ON, Canada; ²Pathology, Western University, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴St. Jude Children's Research Hospital, Memphis, TN.
[Background] Ischemia-reperfusion injury (IRI), a complex limiting factor in organ transplant survival, is related to multiple death pathways. Eliminating the key necroptotic molecule (RIPK3) improves…
2015 American Transplant Congress
IL-17 Production Influenced by Induction Therapy With ATG
D. Abendroth,¹ M. Marzinzig,¹ J. Kaden.²
¹Center of Surgery, University of Ulm, Ulm, Germany; ²Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany.
Introduction Immune-mediated rejection remains the most important cause of graft failure. Recently, a newly identified CD4+ T cell subset, Th17, distinct from Th1 or Th2,…
2015 American Transplant Congress
Inflammatory Profiling of Hypothermic Machine Pumped Kidney Allografts
J. Cohen, E. Ratigan, A. Shigeoka, R. Steiner, L. Stocks, D. McKay.
Medicine, University of California, San Diego, La Jolla, CA.
Background:Pulsatile Hypothermic Machine Perfusion (MP) offers an opportunity to define inflammatory molecules generated during renal ischemia. This study reports on allografts pumped at our OPO,…
2015 American Transplant Congress
Allogeneic Monocyte–Endothelial Cell Interaction Plays a Critical Role in Initiating Early Pro-Fibrosis Responses
E. Gall, H. Xu, K. Samy, A. Kirk.
Surgery, Duke University Medical Center, Durham, NC.
Chronic allograft nephropathy (CAN), characterized by interstitial fibrosis, vascular intimal thickening, and glomerulosclerosis, has remained as leading cause of allograft failure. The role of innate…
2015 American Transplant Congress
Relations Among Hyperuricemia, Inflammation, Oxidative Stress and Arterial Stiffness in Renal Transplant Recipients
B. Gurlek Demirci,¹ S. Sezer,¹ M. Erkmen Uyar,¹ Z. Bal,¹ E. Tutal,¹ F. Ozdemir Acar,² M. Haberal.³
¹Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey; ²Department of Nephrology, Baskent University Faculty of Medicine, Istanbul, Turkey; ³Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.
Purpose: Uric acid is the end product of purine metabolism and has well known anti-oxidant effects. Superoxide dismutase (SOD) and malondialdehyde (MDA) are well-known antioxidant…
2015 American Transplant Congress
Ischemia Reperfusion Injury in Orthotopic Liver Transplantation Primes the Adaptive Immune Response and Generation of Proinflammatory Cytokines
A. Zarrinpar,¹ P. Rao,² C. Lassman,² V. Agopian,¹ F. Kaldas,¹ D. Farmer,¹ R. Busuttil,¹ Y. Zhai,¹ J. Kupiec-Weglinski,¹ E. Reed.²
¹Surgery, University of California, Los Angeles, Los Angeles, CA; ²Pathology and Lab Medicine, University of California, Los Angeles, Los Angeles, CA.
Background: Transplanted organs are exquisitely susceptible to effects of ischemia/reperfusion injury (IRI), an immune-mediated process that occurs during transplantation and beyond. Recipient and graft outcomes,…
2015 American Transplant Congress
The Molecular Landscape of Atrophy-Fibrosis in Human Kidney Transplants: The Dominant Role of Acute Parenchymal Injury
J. Venner, P. Halloran.
University of Alberta, Edmonton, Canada.
We studied the effect of time post-transplant on atrophy-fibrosis (AF) and molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days to…