ATC Abstracts

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Articles tagged "Inflammation"

  • 2015 American Transplant Congress

    Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)

    R. Catar,1 C. Luecht,1 M. Simon,1 A. Philippe,1 A. Kusch,1 M. Szczepek,2 P. Hildebrand,2 P. Scheerer,2 D. Dragun.1

    1Nephrology and Intensive Care Medicine, Charité, Berlin, Germany; 2Institute of Medical Physics and Biophysics, Charité, Berlin, Germany.

    Microvascular endothelium is major target for antibodies directed against HLA and non-HLA antigens. Functional antibodies targeting G-protein coupled receptors (GPCRs) such as AT1R or ETAR…
  • 2015 American Transplant Congress

    Low Molecular Weight Hyaluronan Increases MIG and MCP-1 Production in Cardiac Allografts

    S. Goparaju,1 A. Kaul,1 N. Dvorina,1 S. Iida,1 K. Keslar,1 R. Fan,1 C. de la Motte,2 A. Valujskikh,1 R. Fairchild,1 W. Baldwin III.1

    1Immunology, Cleveland Clinic, Cleveland, OH; 2Pathobiology, Cleveland Clinic, Cleveland, OH.

    Macrophages engage in extracellular matrix remodeling both degrading and synthesizing hyaluronan. Hyaluronan is a high molecular weight ( > 1000 kDa) extracellular matrix component that…
  • 2015 American Transplant Congress

    Th17 Mediates Inflammatory Responses After Lung Transplantation

    J. Xu,1 L. Wang,1 Q. Chen,2 S. Xia,1 X. Li,1 H. Li,2 Y. Ding.1,3

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Respiratory Diseases, Capital Medical University, Beijing, China.

    Background: Long-term outcomes after lung transplantation are markedly worse than for other organs. The mechanisms that determine lung transplant rejection are not clear. The role…
  • 2015 American Transplant Congress

    Bariatric Surgery Prolongs Allograft Survival by Promoting Th2 Conditions

    M. Quante, A. ElKhal, H. Rodriguez, R. Abdi, F. Krenzien, H. Uehara, S. Tullius.

    Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston.

    Background: Obesity is linked to chronic low-grade inflammation. We hypothesized that I) obesity will accelerate allograft rejection linked to pro-inflammatory immune responses and that II)…
  • 2015 American Transplant Congress

    Inhibition of mTOR Modulates SLPI Expression: A Potential Role in Kidney Transplant Patients

    N. Ambrosi,1 A. Dotta,2 C. Pizarro,2 D. Guerrieri,1 A. Gonzalez,2 C. Leiva,2 L. Leon,2 J. Mendiberri,3 M. Rial,2 C. Incardona,4 E. Chuluyan,1 D. Casadei.2

    1CEFYBO, UBA, Buenos Aires, Argentina; 2Fundacion 3er Milenio, INBA, Buenos Aires, Argentina; 3UNICEN, Olavarria, Argentina; 4Fundación GADOR, Buenos Aires, Argentina.

    Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor secreted by inflammatory and epithelial cells. It functions as an endogenous immunomodulatory, with antiinflammatory and…
  • 2015 American Transplant Congress

    Plasma Cell Infiltration: General Overview of Clinical and Pathological Correlations in Renal Transplantation

    C. Nihei, F. Lemos, D. David, P. Souza, F. de Paula, W. Nahas, E. David-Neto.

    Transplantation Service, Hospital das Clinicas-University of São Paulo, São Paulo, SP, Brazil.

    Background and Objective: Plasma cells are known as the final effectors of humoral immune response. Their significance and clinical outcomes are still controversial in kidney…
  • 2015 American Transplant Congress

    Deceased Donor and Class II Donor Specific Antibody Predict Interface Activity While Increased Age at Time of Biopsy Predicts Fibrosis in Long-Term Pediatric Liver Allografts With Normal Liver Tests: iWITH Clinical Trial

    S. Feng,1 J. Bucuvalas,2 A. Demetris,3 K. Spain,4 G. Mazariegos,3 B. Burrell,5 iWITH Investigators.6

    1UCSF, SF; 2U Cincinnati, Cincinnati; 3U Pittsburgh, Pittsburgh; 4Rho, Chapel Hill; 5ITN, Bethesda; 6NIAID/NIDDK/ITN, Bethesda.

    Background: Although multiple single centers have reported deterioration of pediatric liver grafts in the face of normal liver tests, neither risk nor mechanism is understood.Methods:…
  • 2015 American Transplant Congress

    Inverse Monocytic Subset Profile in Blood and Tissue During Heart Transplant Rejection

    T. van den Bosch,1 M. Kraaij,1 K. Caliskan,2 A. Constantinescu,2 O. Manintveld,2 P. Leenen,3 C. Baan,1 M. van Groningen,4 A. Rowshani.1

    1Department of Internal Medicine, Section Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; 2Department of Cardiology, Erasmus Medical Center, Rotterdam, Netherlands; 3Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands; 4Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands.

    Introduction: Increased monocytic infiltration of heart transplant tissue is documented during acute rejection. It is still unclear how changes in circulating monocyte pool relate to…
  • 2015 American Transplant Congress

    MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation

    C. Burghuber,1,2 J. Kwun,1 A. Gibby,1 N. Iwakoshi,1 S. Knechtle.1

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria.

    [Background] Sensitization before transplantation and de novo alloantibodies affect a significant number of patients awaiting kidney transplantation. The type of anti-HLA antibody varies with subgroups…
  • 2015 American Transplant Congress

    Serum Proteins Are Significantly Upregulated in Patients With Clinical Antibody-Mediated Rejection

    A. Gareau,1 I. Gibson,2 C. Wiebe,1 J. Ho,1 D. Rush,1 P. Nickerson.1

    1Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; 2Pathology, University of Manitoba, Winnipeg, MB, Canada.

    Background: Antibody-mediated rejection (ABMR) is a major pathway associated with late graft loss. Although serum de novo donor-specific HLA antibodies are frequently observed in ABMR,…
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