ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2015 American Transplant Congress

    Kynurenine Assay to Detect Inflammation in Transplant Patient: Clinical Results

    D. Abendroth,1 J. Kaden,2 M. Marzinzig,1 M. Stangl.3

    1Center of Surgery, University of Ulm, Ulm, Germany; 2Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany; 3General, Visceral and Transplant Surgery, Ludwig-Maximilians-Universität, München, Munich, Germany.

    Introduction: Ideal biomarker should be specific, sensitive, non-invasive, mirror the benefit of therapy and offer prognostic potential. We developed a test using a colorimetric assay…
  • 2015 American Transplant Congress

    Inflammation in Regions of Tubular Atrophy (IATR) Predicts Adverse Graft Outcome in Patients With Late Graft Dysfunction: A Multicenter Study

    J. Grande,1 R. Leduc,3 A. Matas.2

    1Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; 2Surgery, University of Minnesota, Minneapolis, MN; 3Biostatistics, University of Minnesota, Minneapolis, MN.

    Purpose: Inflammation in regions of tubular atrophy (IATR) is a risk factor for late graft loss. However, IATR is associated with inflammation in non-atrophic regions…
  • 2015 American Transplant Congress

    The Effects of Periostin on Renal Fibrosis After Ischemia-Reperfusion Injury Via p38 MAPK Pathway

    J. An,1,2 S. Yang,3 J. Hwang,4 J. Kim,1 S. Kim,2,5 C. Lim,1,2 Y. Oh,1,2 Y. Kim,2 J. Lee.1,2

    1Seoul National University Boramae Medical Center, Seoul, Republic of Korea; 2Seoul National University Hospital, Seoul, Republic of Korea; 3Seoul National University Kidney Research Institute, Seoul, Republic of Korea; 4Chung-Ang University Hospital, Seoul, Republic of Korea; 5Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

    Ischemia-reperfusion injury during the transplantation procedure is associated with poor long-term allograft outcomes, such as rejection and fibrosis. Periostin, a matricellular protein, has been reported…
  • 2015 American Transplant Congress

    Distinctive Roles of mTORC1 Vs. mTORC2 in Liver Ischemia-Reperfusion Injury

    H. Zhou,1,2 J. Zhu,1,3 S. Yue,1 M. Zhang,3 R. Busuttil,1 Q. Xia,3 J. Kupiec-Weglinski,1 Y. Zhai.1

    1The Dumont-UCLA Transplant Center, UCLA, Los Angeles; 2Liver Transplant Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 3Liver Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.

    Mammalian target of rapamycin (mTOR) exists in two complexes to regulate diverse biological processes. Although mTOR complex 1, the canonical target of rapamycin, has been…
  • 2015 American Transplant Congress

    Comparison of Markers of Inflammation Between Dialysis Patients With and Without Failed Kidney Allograft

    R. Villca-Gonzales, R. Vazquez-Apodaca, D. Hernandez-Ramirez, L. Llorente-Peters, J. Alberu, L. Morales-Buenrostro.

    Nephrology and Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, DF, Mexico.

    BACKGROUND: The rates of morbidity and mortality in patients with a failed kidney transplant are higher than dialysis patients who had never been transplanted. The…
  • 2015 American Transplant Congress

    Neogenin Functions as a Chemokinetic Receptor on Activated CD4+ T Lymphocytes

    L. Boneschansker,1 H. Nakayama,1 M. Eisenga,1 M. Klagsbrun,1 D. Irimia,2 D. Briscoe.1

    1Boston Children's Hospital, Boston; 2Massachusetts General Hospital, Boston.

    Increasing data indicates that axonal guidance cues play a critical role in immunity, both in activation, migration as well as in the process of inflammation…
  • 2015 American Transplant Congress

    Enhanced Production of Macrophage Chemoattractant Protein-1 (MCP-1) Within the Kidney in Brain Death Donors Predicts Recipient Allograft Function

    J. Chen, S. Antipenko, A. Zmijewska, R. Reed, J. Locke, R. Mannon.

    Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.

    Brain death (BD) induces an intense pro-inflammatory state, which may impact recipient immunity and graft function after kidney transplantation. The identification of biomarkers predictive of…
  • 2015 American Transplant Congress

    Donor Organ Resident M2 Type Myeloid Cells Protect Murine Orthotropic Liver Transplants from Ischemia and Reperfusion Injury

    S. Yue, X. Shen, F. Gao, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai.

    The Dumont-UCLA Transplant Ctr., UCLA, Los Angeles, CA.

    Liver ischemia reperfusion injury (lRI) is mediated by a pro-inflammatory immune response initiated by the activation of liver non-parenchymal innate immune cells, such as Kupffer…
  • 2015 American Transplant Congress

    Predictive Value of Postoperative CRP and Procalctonin in Kidney Donors Experiencing Surgical Complications

    Z. Ahmed, R. Tamburrini, J. Wright, N. Kessaris, N. Mamode.

    Renal and Pancreatic Transplantation, Guy's Hospital, London, United Kingdom.

    Introduction: Patients undergoing donor nephrectomy are fit and well individuals. Despite this, 1 in 5 will suffer a perioperative complication causing significant morbidity. Recent published…
  • 2015 American Transplant Congress

    Perfusion Disturbances and Local Infarctions After Experimental Kidney Transplantation Corralte With the Duration of Cold Ischemia Time

    S. Rong,1 R. Chen,1 M. Meier,4 B. Hensen,2 H. Haller,1 K. Hueper,2 F. Gueler.1

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Radiology, Hannover Medical School, Hannover, Germany; 3Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; 4Imaging Center, Hannover Medical School, Hannover, Germany.

    Background: Kidney transplantation in mice is challenging but offers good translational models to study mechanisms of disease. In this study allogenic and isogenic kidney transplantation…
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