2015 American Transplant Congress
CD3+CD4+ROR gamma t+ TH17 Cells Do Not Play a Critical Role in Islet Allograft Rejection
Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA.
We have developed a “color-coded” adoptive transfer model for T cell subset identification that enables serial analysis of islet allograft infiltrating yellow induced regulatory T…2015 American Transplant Congress
Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation
Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…2015 American Transplant Congress
Inflammasome Activation in Hepatocytes and Kupffer Cells Orchestrates the Hepatotoxic Effect of Bile Acids and Can Be Potential Target in the Management of Cholestatic Liver Injury
Purpose: Cholestatic liver injury (CLI) is commonly associated with many hepatobiliary diseases and substantially increases the peri-operative morbidity and mortality in liver surgery and transplantation.…2015 American Transplant Congress
A Non-Haematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents the Transplanted Islet Graft Damage
Purpose. Pancreatic islet transplantation (PITx) is an attractive treatment option for type 1 diabetes patients. While pancreatic islets can successfully engraft after PITx a large…2015 American Transplant Congress
Immunologic, Proangiogenic and Neurogenic Assessment of Allogenic Epineurium of the Human Peripheral Nerve for Potential Application in Prevention of Neuroma Formation
Purpose: Transplantation of epineural sheath may support nerve regeneration after traumatic nerve injuries. Unsolved problem after nerve injury is painful neuroma formation. Natural biologic material,…2015 American Transplant Congress
The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury
Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…2015 American Transplant Congress
Molecular Correlates of Atrophy-Fibrosis in Human Kidney Transplants Provides a New Model of Renal Fibrosis
University of Alberta, Edmonton, Canada.
We studied the effect of time post-transplant on atrophy-fibrosis (AF) and the molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days…2015 American Transplant Congress
Histology of Renal Allografts With DGF Provides Limited Prognostic Information
DGF has been shown to be associated with adverse graft outcomes in renal transplantation. However DGF is heterogeneous histologically and the impact of various histological…2015 American Transplant Congress
Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation
Background: It has been shown that β-catenin is an important regulator of cell development, regeneration, and carcinogenesis. Our previous studies demonstrated the key role of…2015 American Transplant Congress
Intra-Allograft Common Rejection Module (CRM) Expression in Kidney Transplants Diagnoses Acute Rejection and Predicts Long Term Graft Prognosis
Surgery, UC San Francisco, San Francisco, CA.
Background: Previous studies with cross-organ transcriptional analysis of 794 allograft biopsies from kidney, liver, heart and lung transplant patients identified a common rejection module (CRM)…
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