2017 American Transplant Congress
Mechanisms of Fibrosis in the Allograft Kidney: RNA-seq Based Analysis Using Formalin Fixed Biopsies.
Development of allograft fibrosis determines long term graft survival but our understanding of this important complication is incomplete. To gain further insight into this problem…2017 American Transplant Congress
Autotransplantation of the Left Lung for the Treatment of Recurrent Life Threatening Pulmonary Hemorrhage Related to Pulmonary Vascular Malformation: A Unique Chance to Study Ischemia/Reperfusion Injury.
Background: Ischemia reperfusion injury (IRI) remains a major clinical problem in lung transplantation. Here, we report the investigation of IRI in a 17-year-old patient who…2017 American Transplant Congress
Circulating Inflammatory Factors in Deceased Organ Donors Result in Innate Immune Activation.
Surgery, Duke University, Durham, NC
Background: Superior outcomes of living-donor compared to deceased-donor transplants may be related to increased graft immunogenicity at the time of transplant. Donor brain death results…2017 American Transplant Congress
Suppression of Inflammation by Withaferin A in Cerulein-Induced Pancreatitis Model Results in Improved Syngeneic Islet Engraftment.
Introduction: Chronic pancreatitis (CP) is characterized by inflammatory damage to acinar cells followed by islets. In clinical islet autotransplantation, patients with advanced stages of CP…2017 American Transplant Congress
IL-3 Contributes to Development of Basophil-Triggered Cardiac Allograft Fibrosis Development.
Introduction: Organ fibrosis and vasculopathy are major causes of chronic cardiac allograft failure. Resident (donor-derived) fibroblasts are thought to be mainly responsible for excessive production…2017 American Transplant Congress
Human IL-10 Transfection of Porcine Lungs Significantly Increases IL-10 Levels in Vascular Perfusate During Human Blood Perfusion.
PurposePorcine organs are a potential source for clinical xenotransplantation. Pig lungs perfused with human blood exhibit inflammation and loss of vascular barrier function within hours.…2017 American Transplant Congress
Preceeding the Rejection: Clinical Results of a Saliva Test After Renal Transplantation.
Introduction There remains a need for biomarker in transplantation for monitoring and early identification of rejection episodes (R). We developed a colorimetric assay to detect…2017 American Transplant Congress
Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.
Department of Surgery, McGill University Health Centre, Montreal, QC, Canada
Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…2017 American Transplant Congress
Quantity and Functions of CD4–CD8– Double Negative (DN) αβ T Cells in Kidney Is MHC Dependent.
Johns Hopkins University, Baltimore, MD
Background: Prior studies have established important roles of CD4+ T cells, natural killer T cells, and CD4+CD25+FoxP3+ Tregs in kidney ischemia reperfusion injury (IRI) pathogenesis.…2017 American Transplant Congress
Low Level Light Laser Treatment Reduces Macrophage Retention and ROS Levels Following Tissue Injury.
1University of Illinois, Chicago; 2Rush University, Chicago
Following ischemia reperfusion injury, inflamed macrophages switch from oxidative phosphorylation to glycolysis; in contrast, macrophages associated with tissue repair rely on oxidative phosphorylation. The triggers…
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