Articles tagged "Inflammation"

2019 American Transplant Congress
Ikaros/IRF4 Signaling Regulates SIRT1-Mediated Macrophage M2 Shift in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human
K. Kadono¹, K. Nakamura¹, H. Hirao¹, S. Kageyama¹, K. J. Dery¹, T. Ito¹, J. Aziz¹, X. Li², B. Ke¹, R. W. Busuttil¹, J. W. Kupiec‐Weglinski¹
¹Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and rejection in liver transplantation (LT). Despite the efficacy of Sirtuin 1…
2019 American Transplant Congress
CXCL12-CXCR4-Mediated Chemotaxis is a Potential Mechanism for Monocyte Recruitment in Ischemia-Reperfusion Injury in Orthotopic Liver Transplant Patients
A. Q. Terry¹, R. A. Sosa¹, B. V. Naini¹, V. Groysberg¹, F. M. Kaldas², R. W. Busuttil², D. Gjertson¹, J. Kupiec-Weglinski², E. F. Reed¹
¹Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ²Surgery, University of California, Los Angeles, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) elicits cellular damage which lowers allograft survival in orthotopic liver transplant (OLT) patients. Damage-associated molecular patterns, such as high-mobility group box…
2019 American Transplant Congress
Role of NF-kB in Release of Isletokines via Exosomes in Response to Islet Stress
P. Saravanan¹, M. Kanak¹, J. Kalivarathan¹, M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX
*Purpose: Human islets are exposed to a range of inflammatory stimuli upon transplantation that leads to poor graft survival. Identifying the various signaling events may…
2019 American Transplant Congress
Withaferin A Shifts Circulating Lymphocytes toward Protective T Cell Subsets and Prolongs Islet Allograft Survival in a Mouse Transplant Model
K. Kumano¹, M. Kanak², C. Darden³, S. Vasu¹, Y. Liu⁴, M. C. Lawrence¹, B. Naziruddin⁴
¹Baylor Scott and White Research Institute, Dallas, TX, ²Department of Surgery, Virginia Commonwealth University, Richmond, VA, ³Institute of Biomedical Studies, Baylor University, Waco, TX, ⁴Baylor Simmons Transplant Institute, Dallas, TX
*Purpose: : Immunosuppression protocols improve the efficacy of allogeneic islet transplantation. However, decline in islet graft function and toxicities imposed by current immunosuppressant drugs remain…
2019 American Transplant Congress
Cyclo (his-pro) Protects Against Gentamicin Induced Cell Apoptosis And Cisplatin Induced Acute Kidney Injury Through Inhibiting P53 Mediated Apoptotic Pathway.
Y. Kim¹, J. Moon¹, J. Jeong¹, J. Kim¹, S. Lee¹, M. Yu², C. Lee³, Y. Kim¹, S. Yang⁴
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, ³Internal Medicine, Cheju Halla General Hospital, Cheju, Korea, Republic of, ⁴Kidney Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Cyclo(His-Pro) (CHP) is an endogenous cyclic dipeptide that exerts cellular protective effects against anti-oxdative damages. However, the role and mechanisms for CHP in preventing…
2019 American Transplant Congress
Targeting Syk Signaling in Myeloid Cells Protects against Liver Fibrosis and Hepatocarcinogenesis
A. Torres-Hernandez, W. Wang, G. Miller
Surgery, NYU School of Medicine, New York, NY
*Purpose: The purpose of our study was to evaluate the mechanistic role of Spleen Tyrosine Kinase (SYK) signaling on the fibrosis - hepatocarcinogenesis axis and…
2019 American Transplant Congress
IL-6R Blockade with Tocilizumab Increases Tregs and Decreases Early Graft Inflammation in Kidney Transplant Recipients: Results of a Randomized Controlled Trial
S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Joanes, F. Vincenti
UCSF, San Francisco, CA
*Purpose: IL-6, a proinflammatory cytokine and key regulator of Treg/Th17 balance, is strongly associated with renal graft rejection. We hypothesized that IL-6 blockade with tocilizumab…
2019 American Transplant Congress
Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation
P. Saravanan¹, M. Kanak¹, G. Yoshimatsu², C. Darden², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Research Center, Dallas, TX
*Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…
2019 American Transplant Congress
Alteration in Local Complement Activation in First 24h Post-Lung Transplantation (LTx) Helps Identify Recipients Developing Primary Graft Dysfunction
H. Kulkarni¹, M. Elvington², L. Ma¹, M. Cano¹, K. Pugh³, R. Hachem¹, J. Atkinson², A. Gelman³
¹Pulmonary and Critical Care Medicine, Washington University, Saint Louis, MO, ²Rheumatology, Washington University, Saint Louis, MO, ³Surgery, Washington University, Saint Louis, MO
*Purpose: Primary graft dysfunction (PGD) is a form of acute lung injury driven by ischemia-reperfusion mediated damage. An increase in plasma complement proteins - specifically…
2019 American Transplant Congress
Novel Insights into Blocking the IL-6 / IL-6 Receptor Pathway after Pig Kidney Xenotransplantation in Baboons
H. Hara¹, G. Zhang¹, H. Iwase¹, T. Yamamoto¹, D. Ayares², D. E. Eckhoff¹, D. K. Cooper¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Revivicor Inc., Blacksburg, VA
*Purpose: IL-6 plays an important role in inflammation. The aims of the study were (i) to measure IL-6 in serum in baboons that received IL-6…