2019 American Transplant Congress
Matrix Metalloproteinase-9 and Neutrophil Extracellular Traps in Human and Mouse Liver Ischemia and Reperfusion Injury
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Neutrophils are key mediators of ischemia/reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Once activated, they release nuclear DNA web-like structures called neutrophil extracellular…2019 American Transplant Congress
Microcirculation Inflammation with TCMR is Associated with Poor Graft Outcomes in Kidney Transplant Recipients (KTRs) without ABMR
*Purpose: Glomerulitis (g) and peritubular capillaritis (ptc), defined as microcirculation inflammation lesions (MI), are a hallmark of ABMR in KTRs. Their significance in KTRs with…2019 American Transplant Congress
Recipient Myeloid Notch1 Disruption Shifts Neutrophil towards Anti-Inflammatory Phenotype and Protects Liver Grafts from Ischemia-Reperfusion Injury
*Purpose: Liver ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and predisposes to rejection crises in orthotopic liver transplantation (OLT). We…2019 American Transplant Congress
Clazakizumab Acts on Endothelial Cells to Limit Antibody Mediated Damage
*Purpose: Human microvascular endothelial cell expression of HLA class II antigens is strongly increased, both in vitro and in vivo, under inflammatory conditions. HLA class…2019 American Transplant Congress
Damage-Associated Molecular Pattern Release and Toll-Like Receptor Activation during Cold Storage and Ex Vivo Reperfusion of Old Rat Livers
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Donor age is one of the most important predictive factors of graft outcome in liver transplantation. The aim of this study was to investigate…2019 American Transplant Congress
Outcomes of Phenotypes in Early Subclinical Inflammation (SCI) Determined by Presence of Interstitial Inflammation with or without Concomitant Tubulitis
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Low levels of renal allograft inflammation in the early post transplant period appear to have an impact on renal architecture and function. However, the…2019 American Transplant Congress
ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy
*Purpose: Complement promotes vascular inflammation in transplant organ rejection, a process leading to cardiac allograft vasculopathy. In this study, we identify a new Rab5 effector…2019 American Transplant Congress
Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation (Tx) but rarely compared directly in a clinical setting. Therefore, we compared a…2019 American Transplant Congress
The Impact of Thrombin / Protease-Activated Receptor-1 Pathway in Hepatic Ischemia-Reperfusion Injury in Mice
*Purpose: Coagulation cascade is an important pathway in the pathophysiology of hepatic ischemia-reperfusion injury(IRI). Generation of thrombin is a critical factor of coagulation induced by…2019 American Transplant Congress
The Crucial Role of Molecular Microscope in the Interpretation of Ambiguous Lesions Such as Banff Borderline Changes and Tubulo-Interstitial Inflammation Accompanying PVAN
*Purpose: Anti-rejection treatment implementation is highly dependent on morphologic lesions interpretation based on Banff classification. Unfortunately, some light microscopic phenotypes are ambiguous which constricts the…
- « Previous Page
- 1
- …
- 18
- 19
- 20
- 21
- 22
- …
- 41
- Next Page »