Articles tagged "Inflammation"

2022 American Transplant Congress
Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance
R. A. Sosa¹, T. Mone², B. V. Naini¹, D. B. Kohn³, E. F. Reed¹, K. Wheeler², B. Campo-Fernandez³, A. Davila³, D. J. Chaffin⁴, J. DiNorcia⁵, F. M. Kaldas⁵, A. Cohen², E. Lum⁶, J. L. Veale⁷, N. M. Kogut⁷
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²One Legacy, Los Angeles, CA, ³Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, ⁴LifeStream Blood Bank, San Bernadino, CA, ⁵Surgery, UCLA, Los Angeles, CA, ⁶Medicine, UCLA, Los Angeles, CA, ⁷Urology, UCLA, Los Angeles, CA
*Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…
2022 American Transplant Congress
Galectin-3 Discriminates Patients with Advanced Cirrhosis and Predicts Post-Liver Transplant Infectious Complications
E. Cervantes-Alvarez¹, M. Vilatobá¹, J. Argemi², N. Limon-de la Rosa¹, O. Mendez-Guerrero¹, C. Huang³, D. Kershenobich¹, R. Bataller⁴, A. Torre⁵, N. Navarro-Alvarez¹
¹Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Liver Unit, Clinica Universidad de Navarra, Hepatology Program, Center for Applied Medical Research, Pamplona, Spain, Pamplona, Spain, ³University of Colorado Anschutz Medical Campus, Denver, CO, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico city, Mexico
*Purpose: An increased demand for liver transplantation (LT) prevails. Galectin-3 is a lectin implicated in inflammation, immunoregulation, and liver fibrosis. In this study we assessed…
2022 American Transplant Congress
Nebulized Mitochondria Localize to Transplanted Allografts and Improve Outcomes Following Lung Transplantation
D. Nord¹, Z. Tu², L. Langerude¹, A. McQuiston¹, J. Kwon³, S. Nadig⁴, T. Machuca⁵, C. Atkinson¹
¹Pulmonary Medicine, University of Florida, Gainesville, FL, ²University of Florida, Gaineville, FL, ³MUSC College of Medicine, Charleston, SC, ⁴Northwestern University, Charleston, SC, ⁵Department of Surgery, University of Florida, Gainesville, FL
*Purpose: Mitochondrial transplantation therapy is an innovative strategy for the treatment of mitochondrial dysfunction. The approach has shown efficacy in the treatment of cardiac ischemic…
2022 American Transplant Congress
Discordant Histological Findings During Acute Rejection in a Combined Face and Hand Transplant Recipient
O. C. Onuh¹, J. Trilles¹, W. J. Rifkin¹, H. Brydges¹, B. F. Chaya¹, R. Rodriguez Colon¹, D. Boczar¹, D. J. Ceradini¹, E. D. Rodriguez¹, B. E. Gelb²
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: The purpose of this study is to evaluate histologic findings in a face and bilateral hand transplant recipient that was monitored with multi-site allograft…
2022 American Transplant Congress
NecroX-7 Ameliorate FK506-Induced Nephrotoxicity in LLC-PK1 Cells (Pig Kidney Epithelial Cells)
H. J. Jang
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of
*Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
2022 American Transplant Congress
Variability of Serum Klotho and FGF-23 Levels During the First Two Years After Kidney Transplantation
T. Vazquez-Sanchez¹, M. Sanchez-Niño², P. Ruiz-Esteban¹, V. López¹, J. Delgado¹, A. Ortiz³, D. Hernández¹
¹Nephrology Department, Regional University Hospital (IBIMA), REDinREN (RD16/0009/0006), Malaga (España), Malaga, Spain, ²Nephrology Department, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Universidad Autónoma de Madrid. REDINREN, Madrid, Spain, ³Nephrology Department, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Universidad Autónoma de Madrid. REDINREN, Madrid, Spain, Madrid, Spain
*Purpose: Klotho is a protein produced in renal tubular cells with nephroprotective actions which acts as a co-receptor for phosphaturic factor FGF-23. The natural history…
2022 American Transplant Congress
An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion Injury in a Murine Model
S. Duarte, A. Kobayashi, V. Boominathan, A. Kwiatkowski, J. Simonovich, A. Wanchoo, G. Hudalla, B. Keselowsky, A. Zarrinpar
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…
2022 American Transplant Congress
Circulating Donor-Derived Cell-Free DNA: A Novel Non-Invasive Biomarker for Immune Surveillance in Vascularized Composite Allotransplantation
W. J. Rifkin¹, J. Trilles¹, P. S. Rabbani¹, O. C. Onuh¹, B. E. Gelb², D. J. Ceradini¹, E. D. Rodriguez¹
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: The purpose of this study is to evaluate whether circulating donor-derived cell-free DNA (dd-cfDNA) could be used as a noninvasive biomarker to detect rejection…
2022 American Transplant Congress
Adenosine A2A Receptor (A2AR) Agonist Apadenoson Promotes Survival in K28-hACE2 Mice and Syrian Hamsters Infected with Sars-CoV-2
P. Chhabra¹, B. Mann², M. Ma¹, S. Feldman³, J. Linden⁴, K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA, ³Center for Comparative Medicine, University of Virginia Health System, Charlottesville, VA, ⁴Department of Nephrology, University of Virginia Health System, Charlottesville, VA
*Purpose: To determine if Apadenoson or Regadenoson has a therapeutic effect in attenuating hyper-inflammation and improving survival rate in K18-hACE2mice or Syrian hamsters infected with…
2022 American Transplant Congress
Inflammation After Kidney Transplantation Is Associated With Overall- And Death-censored Graft Loss
T. F. Heldal, T. Jenssen, A. Hartmann, K. Heldal, A. Asberg
Department of Transplantational Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
*Purpose: Early graft loss after kidney transplantation (KT) is mainly a result of acute rejection, while long-term graft loss episodes are often dependent on multifactorial…