Articles tagged "Inflammation"

2022 American Transplant Congress
Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets
J. Warunek¹, A. Lucas², L. R. Mathews², M. Oberbarnscheidt², F. Lakkis², H. Turnquist²
¹Immunology, Thomas E. Starzl Transplantation Institute, University at Pittsburgh, Pittsburgh, PA, ²Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…
2022 American Transplant Congress
Prevention of the Progression in Chronic Calcineurin Inhibitors Nephrotoxicity via Steroids Anti-Inflammatory Effects
N. Iwahara¹, K. Hotta¹, Y. Tanaka¹, I. Takahashi¹, R. Hasebe¹, H. Okada¹, T. Tsuji², Y. Takada², H. Higuchi², H. Sasaki¹, T. Tanabe¹, D. Iwami³, N. Shinohara¹, M. Murakami¹
¹Hokkaido Univercity, Sapporo, Japan, ²Sapporo City General Hospital, Sapporo, Japan, ³Jichi Medical University, Shimotsuke, Japan
*Purpose: Calcineurin inhibitors (CNI) lead to an excellent short-term kidney allograft outcome. However, chronic nephrotoxicity is a major concern, which affects a long-term allograft survival.…
2022 American Transplant Congress
Allo-Sensitization is Increased in Liver Transplant Recipients Following Ischemia-Reperfusion Injury
R. A. Sosa, A. Q. Terry, Y. Yin, B. V. Naini, F. M. Kaldas, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed
UCLA, Los Angeles, CA
*Purpose: Recipient sensitization to donor HLA antigens remains an important clinical problem in transplantation, leading to increased wait times to find a compatible donor and…
2022 American Transplant Congress
Sting but Not Mtor Signaling Regulates Exogenous Mitochondrion-Induced Endothelial Cell Mitophagy
H. Xu, L. Wang, A. D. Kirk, H. Xu
Duke University School of Medicine, Durham, NC
*Purpose: We have previously demonstrated activation and increasing mitophagy of human endothelial cells (ECs) following exogenous mitochondrion-stimulation. The objectives of this study were to evaluate…
2022 American Transplant Congress
Evs from Patients with Amr Induce Tubular Senescence and Endmt Through Horizontal Transfer of Mirnas
R. Franzin¹, A. Stasi¹, F. Sallustio¹, S. Bruno², G. Merlotti³, M. Quaglia³, G. Grandaliano⁴, P. Pontrelli¹, J. Thurman⁵, G. Camussi², G. Stallone⁶, V. Cantaluppi³, L. Gesualdo¹, G. Castellano⁷
¹DETO, University of Bari, Bari, Italy, ²University of Turin, Turin, Italy, ³University of Piemonte Orientale, Novara, Italy, ⁴Università Cattolica Sacro Cuore, Rome, Italy, ⁵University of Colorado School of Medicine, Aurora, CO, ⁶University of Foggia, Foggia, Italy, ⁷University of Milan, Milan, Italy
*Purpose: Extracellular vesicles (EV) are emerging mediators in several diseases; however, their role in antibody-mediated allograft rejection (AMR) has been poorly investigated.*Methods: Plasma EVs from…
2022 American Transplant Congress
Post-Operative Day 1 Galectin-3 is Predictive of Early Allograft Dysfunction in Liver Transplantation
D. Yoeli, T. Ferrell, I. Rodriguez, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, R. Choudhury, M. Adams, T. Nydam, E. Pomfret, C. Huang, N. Navarro Alvarez, H. Moore
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: Early allograft dysfunction (EAD) is an important outcome measure in liver transplantation that is predictive of graft failure, but the mechanism behind it remains…
2022 American Transplant Congress
Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping
O. C. Rodriguez¹, J. R. Liggett², J. Kang², K. Loh², Y. Lee¹, N. Sang¹, B. He¹, Y. Cui², K. Oza², D. Kwon³, B. Kallakury³, T. Fishbein², W. Cui², K. Khan², C. Albanese¹, A. Kroemer²
¹Lombardi Comprehensive Cancer Center and the Center for Translational Imaging, Georgetown University Medical Center, Washington, DC, ²MedStar Georgetown Transplant Institute, Washington, DC, ³Pathology, MedStar Georgetown University Hospital, Washington, DC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…
2022 American Transplant Congress
Cd137 on Host Dendritic Cells Fine-Tunes the Intesity of Donor T Cells in Systemic Alloinmmune Responses
S. Park¹, H. Cho², B. Kwon³, J. Lee⁴, H. Park¹, J. Park⁴, K. Park⁴, K. Yoo⁴
¹Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ²University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ³School of Biological Sciences, University of Ulsan, Ulsan, Korea, Republic of, ⁴Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea, Republic of
*Purpose: CD137 is a potent costimulatory receptor for CD8+ T cells but it also regulates dendritic cells (DCs) to suppress immune responses. In this study,…
2022 American Transplant Congress
Anti-Fibrotic Property of Adipose Derived Regenerative Cells on Hydrogen Peroxide Induced Injury in Nrk-52e Cells
R. Chawangwongsanukun¹, R. Lathan¹, R. Pearson², M. Clancy², P. Mark¹
¹Institute of Cardiovascular and Medical Sciences, Glasgow, United Kingdom, ²Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom
*Purpose: Adipose derived regenerative cells (ADRCs) are a heterogenous cell population derived from adipose tissue. These cells are composed of endothelial progenitor cells, pericytes, and…
2022 American Transplant Congress
Plasma Galectin-3 is Predictive of Post-Transplant Infection in Pediatric Liver Transplant Recipients
D. Yoeli, A. Chaidez, Y. Luo, J. Huang, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, M. Adams, C. Mack, C. Huang, N. Navarro-Alvarez
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: Galectin-3 (Gal3) is a beta-galactoside binding lectin that plays a key role in inflammation and immune response. Infectious complications are common among pediatric liver…